NFL Week 4 Predictions: Picks & Odds for Marquee Games

The NFL's Week 4 is the last week before bye weeks begin, and we're rounding up our top predictions and picks for the 16-game slate.

Esten McLaren

Last Updated: September 29, 2024 8:47 PM EDT • 3 minute read

Detroit Lions receiver Amon-Ra St. Brown (14) celebrates as we offer our NFL Week 4 predictions. — Detroit Lions receiver Amon-Ra St. Brown (14) celebrates against the Arizona Cardinals. Photo by Joe Rondone / The Republic via Imagn Images.

Week 4 is our last week before byes begin. The 16-game slate will conclude with another doubleheader of the Monday Night Football odds.

The week concludes with the Miami Dolphins hosting the Tennessee Titans at Hard Rock Stadium, and the Detroit Lions welcoming the Seattle Seahawks to Ford Field. Both home teams are short favorites.

Our C Jackson Cowart broke down all of the Super Bowl odds movement from Week 4's Sunday slate. The Kansas City Chiefs remain the consensus Super Bowl odds favorites despite another narrow victory.

We're already looking ahead to the NFL Week 5 odds with the help of Mike Spector's Buccaneers vs. Falcons early picks for Thursday Night Football.

NFL picks & predictions Week 4

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Titans vs. Dolphins early picks

Seahawks vs. Lions early picks

First touchdown scorer predictions for Monday Night Football

Don't miss the rest of our Week 4 NFL picks. Listed odds for all games via bet365 unless stated otherwise.

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NFL odds for Monday

Titans vs. Dolphins odds

Prediction: Dolphins -1.5 (-108 via DraftKings) vs. Titans ⭐⭐⭐⭐

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Pick made by Mike Spector.

When: Monday, Sept. 30 - 7:30 p.m. ET
Where: Hard Rock Stadium, Miami Gardens, Fla.
How to watch: ESPN
Moneyline: Titans -110 | Dolphins -110
Spread: Titans -1 (-105) | Dolphins +1 (-115)
Total: 37 (-110/-110)

Seahawks vs. Lions odds

Prediction: Jaxon Smith-Njigba Over 47.5 receiving yards (-114 via FanDuel) ⭐⭐⭐⭐

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Pick made by Mike Spector.

When: Monday, Sept. 30 - 8:15 p.m. ET
Where: Ford Field, Detroit
How to watch: ABC
Moneyline: Seahawks +175 | Lions -210
Spread: Seahawks +4 (-110) | Lions -4 (-110)
Total: 46.5 (-110/-110)

NFL picks roundup: Week 4

NFL betting odds pages

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Written by:
Esten McLaren

Esten is the Senior Publishing Editor for SportsbookReview.com. He has been in the sports betting industry since the legalization of mobile sports betting in New Jersey, and with SportsbookReview prior to the launch of sports betting in Ontario. Esten's previous stops include the USA TODAY network, including GolfWeek. He previously worked in the fantasy sports industry, with FNTSY Sports Network, theScore, and USA TODAY. Esten graduated from the College of Sports Media with a diploma in Radio and Television Sports Broadcasting after acquiring a degree in Biological Sciences from the University of Guelph. He has appeared on FNTSY Sports Network, VSiN, and VSiN's Long Shots podcast, where he correctly called Will Zalatoris as the winner of the 2022 FedEx St. Jude Championship. Esten is a big proponent of the entertainment side of sports betting and loves to dip his toes into the novelty and alt-markets while chasing long shots with reduced wagers on golf outrights and futures markets. He's also been known to sprinkle some lunch money on touchdown-scorer parlays with two notable hits still funding his bankroll. Esten looks at sports betting much like golf and advises beginner bettors to compete against themselves rather than being concerned with what others may or may not be doing based on social media claims.