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Patrick Mahomes of the Kansas City Chiefs looks to the sidelines during the first quarter of a preseason game against the Arizona Cardinals, and we offer new U.S. bettors our exclusive Caesars promo code.
Patrick Mahomes of the Kansas City Chiefs looks to the sidelines during the first quarter of a preseason game against the Arizona Cardinals. Photo by Norm Hall/Getty Images via AFP.

Our Week 5 NFL parlay predictions depend heavily on Patrick Mahomes and the Kansas City Chiefs' offense delivering a stellar performance, relying on the most promising NFL odds available.

The Kansas City Chiefs have struggled to surpass the 23-point mark in three out of their first four games this season, including their recent narrow 23-20 victory against the New York Jets.

However, the opportunity to face a vulnerable Minnesota Vikings defense on the fast-paced turf at U.S. Bank Stadium seems like an ideal chance for Mahomes and the Chiefs offense to regain their form.

Here are our best NFL parlay predictions (odds via our best NFL betting sites; pick confidence based on a 1-to-5-star scale).

Best NFL Week 5 parlay predictions

Cincinnati Bengals vs. Arizona Cardinals Under 44.5 (-106 via FanDuel) ⭐⭐⭐

Until Joe Burrow’s calf injury has healed - something that might not happen for a while since the 1-3 Bengals can’t afford to keep their star QB out of the lineup - Cincinnati’s offense is going to be a shell of its former self.

Burrow’s lack of mobility and inability to step into his throws are preventing him from taking shots down the field, and it’s evident in the numbers. Through four games, the Bengals are dead last in the NFL in total yards and yards per play, and they rank 29th in passing yards despite chucking it the fifth-most times in the league.

In order to hang in the playoff race, Cincy’s going to have to get the job done with its defense, which is the way the Bengals have had most of their recent road success anyway. Cincinnati has gone Under the total in five straight as the visitor and is 14-3-1 to the Under in its last 18 away from home.

Josh Dobbs and the Arizona offense have been a pleasant surprise so far, but let’s not forget that Dobbs entered the season with a career touchdown-to-interception ratio of 2:3. After throwing four touchdowns without a pick in the first four games, Dobbs is due for some regression. Expect it this week as both teams struggle to score into the 20s.

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Philadelphia Eagles ML (-215 via FanDuel) ⭐⭐⭐⭐

Despite starting the season 4-0, the Eagles have been far from impressive, needing overtime to get past the Washington Commanders last week for their third one-score victory of September.

However, that gives us a chance to back the defending NFC champs at a cheaper price than we would have had to lay at the start of the season, especially with the Los Angeles Rams exceeding expectations with a 2-2 start.

Los Angeles has been even better to bettors, going 3-0-1 ATS in those first four games, but this is a horrible scheduling spot. Not only are the Rams returning home from back-to-back games out east, but they were grueling affairs - a hard-fought loss to the Bengals on Monday Night Football, followed by last week’s overtime win over the Indianapolis Colts.

Yes, Cooper Kupp could make his season debut for the Rams, but Matt Stafford might have difficulty throwing to him after suffering a hip contusion against Indianapolis. Even if Stafford starts (he was listed as questionable on Wednesday), there’s no guarantee he will get through the game against a fierce Philly pass rush.

I’m not eager to lay more than a field goal on the road with an Eagles group struggling to win by a big margin, but Philly should be able to handle an L.A. team that could be running on fumes.

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Kansas City Chiefs Over 27.5 (-132 via FanDuel) ⭐⭐⭐⭐⭐

The Chiefs’ offense has sputtered this year by its own lofty standards, scoring 23 points or less in three of their first four outings. Patrick Mahomes was picked off twice in last week’s 23-20 win at the Jets, a game in which Kansas City roared out to an early 17-0 lead before seeming to take its foot off the gas.

If anything, those early season struggles and a tight win over the Jets should make Kansas City hungry for a breakout performance, and a date with the Vikings presents the perfect opportunity.

Sure, Minnesota held the Panthers’ offense to a pair of field goals last week, but that’s more of an indictment of Carolina’s woeful attack. In their previous two games, the Vikes gave up an average of 31 points in losses to the Los Angeles Chargers and Eagles, allowing more than 450 passing yards in one of those games and 250-plus rushing yards in the other.

Kansas City's lowest-scoring games have come against tough defenses in the Jets, Detroit Lions, and Jacksonville Jaguars, but in the one game they played against a subpar stop unit, they lit up the Chicago Bears for 41. Look for a similar performance this week, especially if a strong Vikings attack can put up some points of its own to keep the pressure on Kansas City to score.

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NFL Week 5 parlay: +400 via FanDuel

Week 5 NFL parlay picks made Thursday at 4:15 p.m. ET

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