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NFL Thanksgiving Predictions 2023: Props, Picks & Odds for All 3 Turkey Day Games

Esten McLaren

Last Updated: November 23, 2023 4:38 PM EST • 1 min 19 sec read.

Brock Purdy #13 of the San Francisco 49ers hands off the ball as we round up our NFL Thanksgiving predictions.
Brock Purdy #13 of the San Francisco 49ers hands off the ball to Christian McCaffrey #23 of the San Francisco 49ers during the first quarter of a game against the Tampa Bay Buccaneers at Levi's Stadium on November 19, 2023 in Santa Clara, California. Photo by Thearon W. Henderson/Getty Images via AFP.

The NFL's annual Thanksgiving tripleheader opens Week 12 of the 2023 season and we're rounding up all of our betting experts' top NFL Thanksgiving predictions based on the odds from our best NFL betting sites.

The NFL's Thanksgiving tripleheader opens with the Green Bay Packers visiting the Detroit Lions for a 12:30 p.m. ET kickoff. The Dallas Cowboys and Washington Commanders will follow suit at 4:30 p.m. with the San Francisco 49ers' visit to play the rival Seattle Seahawks wrapping up the full day of football at 8:20 p.m. ET.

To help bridge the gap to the NFL's Sunday slate, we have our Dolphins vs. Jets predictions for the league's first-ever Black Friday game.

Check out our best NFL Thanksgiving predictions based on the top NFL Week 12 odds and betting lines.    

NFL Thanksgiving schedule and odds

Odds via bet365 as of Tuesday at 10 a.m. ET

25 K Thanks Lobby

NFL Thanksgiving predictions

49ers vs. Seahawks pick: Under 43.5 (-110 via DraftKings) ⭐⭐⭐

49ers-Seahawks prediction made by Brenden Schaeffer.

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NFL expert picks for Thanksgiving

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Written By:
Esten McLaren
Esten is the Senior Publishing Editor for SportsbookReview.com. He has been in the sports betting industry since the legalization of mobile sports betting in New Jersey, and with SportsbookReview prior to the launch of sports betting in Ontario. Esten's previous stops include the USA TODAY network, including GolfWeek. He previously worked in the fantasy sports industry, with FNTSY Sports Network, theScore, and USA TODAY. Esten graduated from the College of Sports Media with a diploma in Radio and Television Sports Broadcasting after acquiring a degree in Biological Sciences from the University of Guelph. He has appeared on FNTSY Sports Network, VSiN, and VSiN's Long Shots podcast, where he correctly called Will Zalatoris as the winner of the 2022 FedEx St. Jude Championship. Esten is a big proponent of the entertainment side of sports betting and loves to dip his toes into the novelty and alt-markets while chasing long shots with reduced wagers on golf outrights and futures markets. He's also been known to sprinkle some lunch money on touchdown-scorer parlays with two notable hits still funding his bankroll. Esten looks at sports betting much like golf and advises beginner bettors to compete against themselves rather than being concerned with what others may or may not be doing based on social media claims.