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Brock Purdy #13 of the San Francisco 49ers hands off the ball as we round up our NFL Thanksgiving predictions.
Brock Purdy #13 of the San Francisco 49ers hands off the ball to Christian McCaffrey #23 of the San Francisco 49ers during the first quarter of a game against the Tampa Bay Buccaneers at Levi's Stadium on November 19, 2023 in Santa Clara, California. Photo by Thearon W. Henderson/Getty Images via AFP.

The NFL's annual Thanksgiving tripleheader opens Week 12 of the 2023 season and we're rounding up all of our betting experts' top NFL Thanksgiving predictions based on the odds from our best NFL betting sites.

The NFL's Thanksgiving tripleheader opens with the Green Bay Packers visiting the Detroit Lions for a 12:30 p.m. ET kickoff. The Dallas Cowboys and Washington Commanders will follow suit at 4:30 p.m. with the San Francisco 49ers' visit to play the rival Seattle Seahawks wrapping up the full day of football at 8:20 p.m. ET.

To help bridge the gap to the NFL's Sunday slate, we have our Dolphins vs. Jets predictions for the league's first-ever Black Friday game.

Check out our best NFL Thanksgiving predictions based on the top NFL Week 12 odds and betting lines.    

NFL Thanksgiving schedule and odds

Odds via bet365 as of Tuesday at 10 a.m. ET

NFL Thanksgiving predictions

49ers vs. Seahawks pick: Under 43.5 (-110 via DraftKings) ⭐⭐⭐

49ers-Seahawks prediction made by Brenden Schaeffer.

NFL Thanksgiving promo codes

NFL expert picks for Thanksgiving

NFL betting odds pages

Check out our best NFL betting sites:

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