NFL Week 12 Odds & Betting Lines: Spread, Moneyline, Over/Under for All 13 Games

The NFL odds for Week 12 are out, and sadly, there are only 13 games. Six teams are on a bye (that happens again in Week 14 when bye weeks finally wrap up), so we're getting a shorter slate.

Our best NFL betting sites have reacted to last week's action, and they'll continue to move the Week 12 odds & betting lines throughout the week.

• The week opened with the Thursday Night Football odds underdog Cleveland Browns upsetting the Pittsburgh Steelers, 24-19, as +3.5-point underdogs as the Over 36.5 cashed
• The Sunday Night Football odds will feature the Super Bowl odds contending Philadelphia Eagles visiting the Los Angeles Rams (8:20 p.m. ET, NBC/Peacock)
• The Monday Night Football odds show the Baltimore Ravens (and NFL MVP odds betting favorite Lamar Jackson) visiting the Los Angeles Chargers (8:15 p.m. ET, ESPN/ABC)
• The Atlanta Falcons, Buffalo Bills, Cincinnati Bengals, New Orleans Saints, New York Jets, and Jacksonville Jaguars on a bye

NFL Week 12 odds and lines

There's an edge to betting NFL odds while trying to beat the closing line. The closer you wait until game time to make your NFL picks, the more difficult it becomes to identify advantages and secure the best number on most side bets or totals.

That's why it's important to start monitoring the NFL opening odds each week as soon as possible. A proactive approach will aid your long-term success.

Best NFL Week 12 spreads

(Odds via DraftKings)

• Divisional rivalry games: Steelers-Browns (TNF), Titans-Texans, Patriots-Dolphins, Cowboys-Commanders, Vikings-Bears, Broncos-Raiders, Cardinals-Seahawks
• Eight of the 13 games have opened with the home squad listed as the underdog; there were no flips based on last week's action
• Only six games are lined with a spread of three or fewer points to open
• That number has slipped to four heading into Thursday Night Football
• ATS leaders heading into Week 12: Steelers (8-2), Lions (8-2), Broncos (8-3), Colts (8-3)
• ATS losers heading into Week 12: Titans (1-9), Cowboys (2-8), Jets (3-8), Panthers (3-7), Browns (3-7), Giants (3-7)

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Best NFL Week 12 moneylines

  (Odds via FanDuel)  

There are always numerous questions that will impact these opening lines once Monday rolls around. Here are some questions we have heading into Week 10:

• Which version of the Browns will we see coming out of their Week 9 bye: A team that can compete, or more of the same?
• The Browns looked awful, failing to compete with the Saints; they've become larger underdogs in response
• Will Sam Darnold continue to turn back into the Sam Darnold of the past? Or can he get back on track in Week 10?
• Darnold didn't look fantastic, but did enough to get past the Titans - who probably weren't the biggest test
• Can Patriots rookie QB Drake Maye keep developing steadily and tighten up this line against the Dolphins?
• The Dolphins had a great performance and pulled further away, despite Maye looking pretty decent against the Rams
• What will Dallas do with its extremely rocky QB situation?
• Monday Night Football will provide us our answer here

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Best NFL Week 12 Over/Unders

  (Odds via bet365)  

• Over leaders heading into Week 12: Ravens (9-2), Bengals (8-3), Panthers (7-3), Bucs (7-3), Raiders (7-3),
• Under leaders heading into Week 12: Texans (3-8), Chargers (3-7), Giants (3-7), Bears (3-7), Vikings (3-7)
• Opening market highs: No games at 50-plus points, as Lions-Colts at 49 is the standalone opening high
• As of Thursday morning, the Lions-Colts (50.5) has been surpassed by the Ravens-Chargers (51)
• Opening market lows: No games at fewer than 40 points, with Vikings-Bears sneaking in at 40.5
• As of Thursday morning, the Steelers-Browns Thursday Night Football tilt is listed at 37, with Vikings-Bears also dropping to 39.5

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NFL betting odds pages

Here are our best NFL betting sites:

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• bet365 Bonus Code: SBRBONUS | Read our bet365 Review
• FanDuel Promo Code | Read our FanDuel Review
• DraftKings Promo Code | Read our DraftKings Review

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Related pages

• Best Sports Betting Sites | Best Sportsbook Promos (U.S. only)