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San Francisco 49ers wide receiver Deebo Samuel Sr. (1) runs the football as we look at the Thursday Night Football odds for Week 15.
San Francisco 49ers wide receiver Deebo Samuel Sr. (1) runs the football. Photo by Kyle Terada-Imagn Images.

The San Francisco 49ers host the Los Angeles Rams as 2.5-point favorites by the Thursday Night Football odds and betting lines for Week 15 with both teams coming off a victory.

The 6-7 Niners are given the nod as home favorites by the NFL Week 15 odds at Levi's Stadium in what's essentially a must-win for the NFC West rivals after snapping a three-game losing skid. The 7-6 Rams have won three of four games to enter Week 15 second in the division.

Kickoff will be at 8:15 p.m. ET on Prime Video. Our Phil Wood sets the stage with his Rams vs. 49ers early picks.

Who's playing Thursday Night Football this week?

Rams vs. 49ers (-2.5)

Here are some quick betting stats on both teams entering Week 15:

Rams49ers
Moneyline7-66-7
Spread6-75-8
Over/Under7-67-6

Thursday Night Football odds Week 15: Rams vs. 49ers

Thursday Night Football picks

Thursday Night Football 2024 results

WeekResultATSTotal
Week 2Bills 31, Dolphins 10Bills +2.5U49.5
Week 3Jets 24, Patriots 3Jets -6.5U39.5
Week 4Cowboys 20, Giants 15Giants +5.5U44.5
Week 5Falcons 36, Buccaneers 30Falcons -2.5O43.5
Week 649ers 36, Seahawks 2449ers -3.5O48.5
Week 7Broncos 33, Saints 10Broncos -2.5O37.5
Week 8Rams 30, Vikings 20Rams +2.5O46.5
Week 9Jets 21, Texans 13Jets -1.5O42.5
Week 10Ravens 35, Bengals 34Bengals +6O53
Week 11Eagles 26, Commanders 18Eagles -4.5U49.5
Week 12Browns 24, Steelers 19Browns +3.5O36.5
Week 13Packers 30, Dolphins 17Packers -3.5U47.5
Week 14Lions 34, Packers 31Packers +3.5O53.5

Thursday Night Football 2024 schedule & how to watch

Week MatchupTime (ET)TV
Week 15Rams vs. 49ers8:15 p.m. ETPrime Video
Week 16Browns vs. Bengals8:15 p.m. ETPrime Video
Week 17Seahawks vs. Bears8:15 p.m. ETPrime Video

Thursday Night Football betting tips

Mind the shorter week

The majority of teams participating in Thursday Night football will be getting just four days between games – and that isn't much time at all to prepare. Teams dealing with personnel or coaching changes or key injuries could be at a major disadvantage. And while those factors are baked into the odds, it's still an element worth your research time.

Expect a slow start

Thursday Night Football may have largely ditched its long-time reputation of being a snoozefest last season. Teams averaged 23.7 points per game last season on Thursday night.

However, a few inflated outputs boosted that number. The Chicago Bears dropped 40 points on the Washington Commanders in Week 5; the Dallas Cowboys put up 41 points on the Seattle Seahawks in Week 13; and the Las Vegas Raiders erupted for 63 points in an embarrassment of the Los Angeles Chargers in Week 15.

Home-field advantage? Not ATS

There are trends that make sense, and then there's the NFL's Thursday Night Football point spread trend, which most certainly does not.

Road teams have been surprisingly potent in recent years despite playing in hostile territory on a short week, going 30-31 SU and 38-22-1 ATS in TNF contests from 2019 through the 2023 regular season.

Check out our list of the best sportsbook promos here!

Thursday Night Football FAQs

Which team gets the most Thursday Night Football appearances in 2024?

The New York Jets, San Francisco 49ers, Seattle Seahawks, Los Angeles Rams, Cincinnati Bengals, and Cleveland Browns will all appear on Thursday Night Football twice during the 2024 NFL season, the most of all teams.

Which team has won the most TNF games?

The Indianapolis Colts are the most prolific team in Thursday Night Football history, having gone an impressive 12-4 since making their first TNF appearance in 2007. The Dallas Cowboys and Baltimore Ravens are next with 12 Thursday Night football wins.

Which teams have logged the most and fewest Thursday Night Football appearances all-time?

Entering the 2024 NFL season, the San Francisco 49ers lead the way with 19 Thursday Night Football games played. The Denver Broncos are right behind with 18, while the Detroit Lions have appeared in only four TNF contests entering - their regular spot on the Thanksgiving slate doesn't count.

How do I watch Thursday Night Football?

With the exception of the NFL 2024 regular-season opener Sept. 5 between the Ravens and host Chiefs (which aired on NBC), all Thursday Night Football games can be found exclusively on Amazon Prime Video.

NFL betting odds pages

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