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San Francisco 49ers quarterback Brock Purdy throws a pass as we look at the Thursday Night Football odds
San Francisco 49ers quarterback Brock Purdy throws a pass. Photo Credit: Sergio Estrada-Imagn Images.

The San Francisco 49ers have begun to slip down the Super Bowl odds leaderboard after falling to 2-3 on the season with a Week 5 loss to the Arizona Cardinals.

Still, San Francisco remains a 3-point road favorite against the rival Seattle Seahawks by the Week 6 Thursday Night Football odds and betting lines. Seattle suffered a second straight loss this week, losing 29-20 at home to the New York Giants.

Mike Spector's 49ers vs. Seahawks prediction gets the week started along with Phil Wood's 49ers vs. Seahawks TNF prop bets, with all of our best NFL betting sites listing the 49ers as consensus 3-point favorites by the NFL Week 6 odds.

Who's playing Thursday Night Football this week?

49ers (-3) vs. Seahawks

Here are some quick betting stats on both teams entering the matchup:

49ersSeahawks
Moneyline2-33-2
Spread2-32-3
Over/Under3-24-1

Thursday Night Football odds Week 6: 49ers vs. Seahawks

  • Point spread: 49ers -3 (-110 via Caesars) | Seahawks +3 (-102 via FanDuel)
  • Moneyline: 49ers -162 via DraftKings | Seahawks +146 via FanDuel
  • Over/Under: Over 47.5 (-105 via FanDuel) | Under 47.5 (-110 via Caesars)
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Thursday Night Football 2024 results

WeekResultATSTotal
Week 2Bills 31, Dolphins 10Bills +2.5U49.5
Week 3Jets 24, Patriots 3Jets -6.5U39.5
Week 4Cowboys 20, Giants 15Giants +5.5U44.5
Week 5Falcons 36, Buccaneers 30Falcons -2.5O43.5

Thursday Night Football 2024 schedule & how to watch

Week MatchupTime (ET)TV
Week 649ers vs. Seahawks8:15 p.m. ETPrime Video
Week 7Broncos vs. Saints8:15 p.m. ETPrime Video
Week 8Vikings vs. Rams8:15 p.m. ETPrime Video
Week 9Texans vs. Jets8:15 p.m. ETPrime Video
Week 10Bengals vs. Ravens8:15 p.m. ETPrime Video
Week 11Commanders vs. Eagles8:15 p.m. ETPrime Video
Week 12Steelers vs. Browns8:15 p.m. ETPrime Video
Week 13Raiders vs. Chiefs3 p.m. ETPrime Video
Week 14Packers vs. Lions8:15 p.m. ETPrime Video
Week 15Rams vs. 49ers8:15 p.m. ETPrime Video
Week 16Browns vs. Bengals8:15 p.m. ETPrime Video
Week 17Seahawks vs. Bears8:15 p.m. ETPrime Video

Thursday Night Football betting tips

Mind the shorter week

The majority of teams participating in Thursday Night football will be getting just four days between games – and that isn't much time at all to prepare. Teams dealing with personnel or coaching changes or key injuries could be at a major disadvantage. And while those factors are baked into the odds, it's still an element worth your research time.

Expect a slow start

Thursday Night Football may have largely ditched its long-time reputation of being a snoozefest last season. Teams averaged 23.7 points per game last season on Thursday night.

However, a few inflated outputs boosted that number. The Chicago Bears dropped 40 points on the Washington Commanders in Week 5; the Dallas Cowboys put up 41 points on the Seattle Seahawks in Week 13; and the Las Vegas Raiders erupted for 63 points in an embarrassment of the Los Angeles Chargers in Week 15.

Home-field advantage? Not ATS

There are trends that make sense, and then there's the NFL's Thursday Night Football point spread trend, which most certainly does not.

Road teams have been surprisingly potent in recent years despite playing in hostile territory on a short week, going 30-31 SU and 38-22-1 ATS in TNF contests from 2019 through the 2023 regular season.

Check out our list of the best sportsbook promos here!

Thursday Night Football FAQs

Which team gets the most Thursday Night Football appearances in 2024?

The New York Jets, San Francisco 49ers, Seattle Seahawks, Los Angeles Rams, Cincinnati Bengals, and Cleveland Browns will all appear on Thursday Night Football twice during the 2024 NFL season, the most of all teams.

Which team has won the most TNF games?

The Indianapolis Colts are the most prolific team in Thursday Night Football history, having gone an impressive 12-4 since making their first TNF appearance in 2007. The Dallas Cowboys and Baltimore Ravens are next with 12 Thursday Night football wins.

Which teams have logged the most and fewest Thursday Night Football appearances all-time?

Entering the 2024 NFL season, the San Francisco 49ers lead the way with 19 Thursday Night Football games played. The Denver Broncos are right behind with 18, while the Detroit Lions have appeared in only four TNF contests entering - their regular spot on the Thanksgiving slate doesn't count.

How do I watch Thursday Night Football?

With the exception of the NFL 2024 regular-season opener Sept. 5 between the Ravens and host Chiefs (which aired on NBC), all Thursday Night Football games can be found exclusively on Amazon Prime Video.

NFL betting odds pages

Check out our best NFL betting sites:

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