Thursday Night Football Odds & Picks Week 15: Rams vs. 49ers TNF Betting Lines 2024
The San Francisco 49ers host the Los Angeles Rams as 2.5-point favorites by the Thursday Night Football odds and betting lines for Week 15 with both teams coming off a victory.
The 6-7 Niners are given the nod as home favorites by the NFL Week 15 odds at Levi's Stadium in what's essentially a must-win for the NFC West rivals after snapping a three-game losing skid. The 7-6 Rams have won three of four games to enter Week 15 second in the division.
Kickoff will be at 8:15 p.m. ET on Prime Video. Our Phil Wood sets the stage with his Rams vs. 49ers early picks.
Who's playing Thursday Night Football this week?
Rams vs. 49ers (-2.5)
Here are some quick betting stats on both teams entering Week 15:
| Rams | 49ers | |
|---|---|---|
| Moneyline | 7-6 | 6-7 |
| Spread | 6-7 | 5-8 |
| Over/Under | 7-6 | 7-6 |
Thursday Night Football odds Week 15: Rams vs. 49ers
Thursday Night Football picks
- Rams vs. 49ers prediction
- Rams vs. 49ers TNF prop bets
- Rams vs. 49ers parlay picks
- Puka Nacua picks, predictions & best bets
- Brock Purdy picks, predictions & best bets
- Anytime touchdown scorer predictions
- First touchdown scorer predictions
Thursday Night Football 2024 results
| Week | Result | ATS | Total |
|---|---|---|---|
| Week 2 | Bills 31, Dolphins 10 | Bills +2.5 | U49.5 |
| Week 3 | Jets 24, Patriots 3 | Jets -6.5 | U39.5 |
| Week 4 | Cowboys 20, Giants 15 | Giants +5.5 | U44.5 |
| Week 5 | Falcons 36, Buccaneers 30 | Falcons -2.5 | O43.5 |
| Week 6 | 49ers 36, Seahawks 24 | 49ers -3.5 | O48.5 |
| Week 7 | Broncos 33, Saints 10 | Broncos -2.5 | O37.5 |
| Week 8 | Rams 30, Vikings 20 | Rams +2.5 | O46.5 |
| Week 9 | Jets 21, Texans 13 | Jets -1.5 | O42.5 |
| Week 10 | Ravens 35, Bengals 34 | Bengals +6 | O53 |
| Week 11 | Eagles 26, Commanders 18 | Eagles -4.5 | U49.5 |
| Week 12 | Browns 24, Steelers 19 | Browns +3.5 | O36.5 |
| Week 13 | Packers 30, Dolphins 17 | Packers -3.5 | U47.5 |
| Week 14 | Lions 34, Packers 31 | Packers +3.5 | O53.5 |
Thursday Night Football 2024 schedule & how to watch
| Week | Matchup | Time (ET) | TV |
|---|---|---|---|
| Week 15 | Rams vs. 49ers | 8:15 p.m. ET | Prime Video |
| Week 16 | Browns vs. Bengals | 8:15 p.m. ET | Prime Video |
| Week 17 | Seahawks vs. Bears | 8:15 p.m. ET | Prime Video |
Thursday Night Football betting tips
Mind the shorter week
The majority of teams participating in Thursday Night football will be getting just four days between games – and that isn't much time at all to prepare. Teams dealing with personnel or coaching changes or key injuries could be at a major disadvantage. And while those factors are baked into the odds, it's still an element worth your research time.
Expect a slow start
Thursday Night Football may have largely ditched its long-time reputation of being a snoozefest last season. Teams averaged 23.7 points per game last season on Thursday night.
However, a few inflated outputs boosted that number. The Chicago Bears dropped 40 points on the Washington Commanders in Week 5; the Dallas Cowboys put up 41 points on the Seattle Seahawks in Week 13; and the Las Vegas Raiders erupted for 63 points in an embarrassment of the Los Angeles Chargers in Week 15.
Home-field advantage? Not ATS
There are trends that make sense, and then there's the NFL's Thursday Night Football point spread trend, which most certainly does not.
Road teams have been surprisingly potent in recent years despite playing in hostile territory on a short week, going 30-31 SU and 38-22-1 ATS in TNF contests from 2019 through the 2023 regular season.
Check out our list of the best sportsbook promos here!
Thursday Night Football FAQs
Which team gets the most Thursday Night Football appearances in 2024?
The New York Jets, San Francisco 49ers, Seattle Seahawks, Los Angeles Rams, Cincinnati Bengals, and Cleveland Browns will all appear on Thursday Night Football twice during the 2024 NFL season, the most of all teams.
Which team has won the most TNF games?
The Indianapolis Colts are the most prolific team in Thursday Night Football history, having gone an impressive 12-4 since making their first TNF appearance in 2007. The Dallas Cowboys and Baltimore Ravens are next with 12 Thursday Night football wins.
Which teams have logged the most and fewest Thursday Night Football appearances all-time?
Entering the 2024 NFL season, the San Francisco 49ers lead the way with 19 Thursday Night Football games played. The Denver Broncos are right behind with 18, while the Detroit Lions have appeared in only four TNF contests entering - their regular spot on the Thanksgiving slate doesn't count.
How do I watch Thursday Night Football?
With the exception of the NFL 2024 regular-season opener Sept. 5 between the Ravens and host Chiefs (which aired on NBC), all Thursday Night Football games can be found exclusively on Amazon Prime Video.
NFL betting odds pages
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