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San Francisco 49ers wide receiver Deebo Samuel walks on the field before the start of the game against the Chicago Bears, and we offer our top Rams vs. 49ers parlay.
San Francisco 49ers wide receiver Deebo Samuel walks on the field before the start of the game against the Chicago Bears. Photo by Cary Edmondson via Imagn Images.

If recent performances by these offenses are any indication, yards through the air could be plentiful on Thursday night’s NFC West clash between the Los Angeles Rams and San Francisco 49ers.

In Thursday’s game, which features a 49.5-point total, our Rams vs. 49ers TNF parlay based on our best Thursday Night Football odds predicts prominent pass-catchers on both sides to rack up the yardage.

The 49ers (-2) host the Rams at Levi’s Stadium in Santa Clara, Calif., on Thursday at 8:15 p.m. ET (Prime Video), and this is just a taste of what we're offering as part of our NFL Week 15 predictions.

Rams vs. 49ers parlay predictions: Thursday Night Football

NFL picks based on the odds from our best NFL betting sites. Odds subject to change.

  • Deebo Samuel Over 49.5 receiving yards (-115) ⭐⭐⭐⭐⭐
  • George Kittle Over 56.5 receiving yards (-140) ⭐⭐⭐⭐
  • Puka Nacua Over 88.5 receiving yards (-115) ⭐⭐⭐⭐

Combined odds: +475 via BetMGM | Implied probability: 17.39%

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SGP predictions for Rams vs. 49ers

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Deebo Samuel Over 49.5 receiving yards (-115) ⭐⭐⭐⭐⭐

Deebo Samuel tweeted then deleted his sentiment about his lack of involvement in the 49ers' offense this week. Thursday’s matchup against the Rams could be a chance for Brock Purdy to make things right.

Squeaky wheel gets the grease

In six of his first seven games prior to his recent downturn, Samuel cleared this receiving total. We like Samuel to get plenty of touches after his complaints on social media, and against a Rams defense allowing the 10th-most passing yards per game, those touches should equate to production.

This line has been a moving target through Thursday morning, but we like Over on Samuel’s receiving total up to 54.5 yards.

George Kittle Over 56.5 receiving yards (-140) ⭐⭐⭐⭐

After the Rams allowed 342 yards through the air against the Bills last week, we see room for multiple pass-catchers in the San Francisco offense to get theirs on Thursday.

If you ignore the snow game against the Bills, George Kittle has been as integral to the Niners' passing game as anyone.

  • Other than a dud in Buffalo, Kittle has compiled 57 or more receiving yards in all seven games since the beginning of October
  • Kittle leads NFL tight ends in yards per reception this season (14.3)
  • The Rams have allowed 23 receptions to tight ends over their past four games

As of this writing, BetMGM offers Kittle’s line at 56.5, which provides an edge over the 59.5-yard line featured at other best sports betting sites.

Puka Nacua Over 88.5 receiving yards (-115) ⭐⭐⭐⭐

With the 49ers pushing the ball downfield according to our parlay predictions, we should expect the Rams to need to force the ball into the air in order to keep pace.

  • Puka Nacua has been Matthew Stafford’s go-to target when healthy and active, clearing this receiving total in five of six full games
  • Typically, Nacua vaults past this total with ease, as he’s averaging 110.3 receiving yards in games where he wasn’t injured or ejected

BetMGM provides an edge on this prop with Nacua’s receiving line at 88.5 yards as opposed to 90.5 at Caesars and DraftKings.

The +475 SGP odds at BetMGM are competitive with the rest of the market, so we’ll play our parlay there considering the better line on the Nacua and Kittle props.

A winning $10 wager on the parlay at BetMGM would profit $47.50.

Thursday Night Football picks

Rams vs. 49ers odds

See all of this week's NFL odds and NFL scores.

Thursday Night Football game info

  • Matchup: Rams vs. 49ers
  • Kickoff: 8:15 p.m. ET
  • Where: Levi’s Stadium (Santa Clara, Calif.)
  • How to watch: Prime Video
  • Weather: 55 degrees, 49% chance of precipitation, wind 14 mph WSW
  • Favorite: 49ers -2 (-130 via BetMGM)

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