Cowboys vs. Cardinals Prediction, Picks & Best Bets: NFL Preseason Week 2 Odds
My best Cowboys vs. Cardinals prediction focuses on the offensive weapons available for both teams tonight.
The Cardinals have played two preseason games, scoring at least 27 in each, while the Cowboys have a solid pass attack led by Joe Milton III and Sam Howell. Kickoff from State Farm Stadium in Glendale, Ariz., is set for 10 p.m. ET (NFL Network, NFL+), with the Cardinals listed as a 1.5-point betting favorite.
🏈 Cowboys vs. Cardinals prediction: NFL preseason Week 2
See the latest NFL odds and our experts' NFL picks for every game this season.
| 💰 Pick | ⚖️ Units | 🧠 Why I bet this |
|---|---|---|
| Cowboys (-102 via DraftKings) | 0.5u → 0.49u | The Cowboys' defense played better in Week 1 than the Cardinals' defense has at any point this preseason. |
| Over 37.5 (-112 via DraftKings) | 1.5u → 1.34u | The Cardinals have scored 57 points this preseason, while allowing 47. |
Total wagered: 2 units | Max profit: 1.83 units
💰 Cowboys vs. Cardinals best bet
Over 37.5 (-112)
The Cardinals have managed at least 368 total yards in their first two preseason games, reaching 423 yards against the Panthers. Most impressively, the Cardinals haven't turned the ball over yet, as the young offensive weapons competing for roster spots work efficiently.
The Cowboys only allowed seven points in their first game, so perhaps they can slow down the Cardinals' offense better than anyone else has. But even if they do, the Cowboys' offense should move the ball with ease. The Cardinals have allowed 695 yards and 47 points through two games.
Score prediction: Cowboys 24 Cardinals 23
🚀 Cowboys vs. Cardinals same-game parlay
If I had more confidence in the Cowboys, I'd make this a full one-unit play. However, while I expect Milton and Howell to lead the Cowboys to victory, the Cardinals' backups have been very competitive in two games. That extra game of experience could help them immensely in this contest. Therefore, while I love the Over, my lack of trust in the Cowboys makes this just a 0.5-unit play for me.
💵 Cowboys vs. Cardinals SGP picks
- Cowboys
- Over 37.5
Best odds: +246 via DraftKings (0.5u → 1.23u)
💵 My betting record for NFL picks
All NFL picks, including SGPs, have been tracked since Aug. 13.
| Bet type | Record | Net profit | ROI |
|---|---|---|---|
| Overall | 7-0 | +6.97 units ✅ | +116.2% ✅ |
| Game picks | 5-0 | +4.48 units ✅ | +89.6% ✅ |
| Parlays | 2-0 | +2.49 units ✅ | +249% ✅ |
💡 How I'm betting Cowboys vs. Cardinals: NFL preseason strategy
Follow all of our NFL analysis and betting advice for the 2026 NFL season.
My strategy for this game is to simply back what's been consistent thus far. The Cardinals have scored 57 points in two games, and each of their quarterbacks has played at a very high level. But the Cardinals' defense hasn't been great, so I'll back the explosiveness of Milton and Howell to lead the Cowboys to victory. However, I'm much more confident in the Over than the Cowboys, which is why the Over is a 1.5-unit play and the Cowboys are just a 0.5-unit one.
📊 Cowboys vs. Cardinals odds: NFL preseason Week 2
Our live Cowboys vs. Cardinals odds update in real time.
🚑 Cowboys vs. Cardinals latest injuries
🌤️ Cowboys vs. Cardinals weather: Saturday, 10 p.m. ET
This game will be played indoors at State Farm Stadium, so weather won't be a factor for Cowboys vs. Cardinals on Saturday.
📺 How to watch Cowboys vs. Cardinals: NFL preseason Week 2
- Date: Saturday, Aug. 22
- Kickoff: 10 p.m. ET
- Location: State Farm Stadium (Glendale, Ariz.)
- TV: NFL Network
- Streaming: NFL+
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