Blue Jays vs. Yankees Prediction & Picks: MLB Odds for Saturday, Aug. 22

My Blue Jays vs. Yankees prediction breaks down the best bets, player props, home run pick, and same-game parlay I’m betting today.
New York Yankees center fielder Trent Grisham strikes out as we make our best Blue Jays vs. Yankees prediction
Pictured: New York Yankees center fielder Trent Grisham strikes out as we make our best Blue Jays vs. Yankees prediction. Photo by Tony Quinn/SipaUSA
Enjoying SBR content? Add us as a preferred source on your Google account Add as a preferred source on Google

The Toronto Blue Jays face the New York Yankees in the second game of their weekend series on Saturday afternoon in the Bronx. My Blue Jays vs. Yankees prediction includes a run total, a pair of player props, and an SGP. 

Toronto is only 1.5 games out of an A.L. Wild Card seed, while the Yankees have been hot lately, winning seven of their last 10 games, improving their standing in the top A.L. Wild Card seed. 

Dylan Cease vs. Ryan Weathers promises to provide a top-tier pitcher's duel from Yankee Stadium today. Catch today's first pitch at 1:35 p.m. ET (ESPN Unlimited, MLB.TV) from Yankee Stadium (Bronx, N.Y.). Oddsmakers have set the moneyline to a pick'em at -104 odds at most shops, while the run total sits at just 6.5. 


⚾ Blue Jays vs. Yankees picks & odds today

See all of our experts’ MLB picks based on the latest MLB odds;

⚾ Pick 💵 Units 📝 Notes
Under 6.5 (+105 via Caesars) 2u → 2.10u Dylan Cease and Ryan Weathers have held past 10 combined lineups to 9 earned runs. 
Heliot Ramos Under 1.5 hits + runs + RBIs (-160 via BetMGM) 4u → 2.5u Ramos has gone Under 1.5 H+R+RBIs in 3 of previous 5 starts for the Yankees. 
Trent Grisham Over 0.5 home runs (+500 via bet365) 0.25u → 1.25u Grisham has 6 homers in August and ranks 78th in hard-hit percentage (46.2) this year. 

Total wagered: 6.25 units | Max profit: 5.85 units

📃 Affiliate disclosure

Sportsbook Review may receive a commission if you sign up through our links. Not intended for use in MA. Bonuses not applicable in Ontario. 21+ only. (Gambling problem? Call 1-800-GAMBLER)


🏆 Who will win Blue Jays vs. Yankees?

The Yankees and Blue Jays have some of the worst lineups in terms of production in the MLB this season. Pitching has been an edge both have wielded, and with a pair of strong starters on the mound today, it's likely a low-scoring game will be the result. Yankees post a 3-2 win over their A.L. East rivals. 

Score prediction: Yankees 3, Blue Jays 2


💰 Blue Jays vs. Yankees prediction & best bet

Under 6.5 (+105)

The Yankees' lineup is among the worst in the MLB this season. Right now, they lack star power, which explains why New York has logged 3 or fewer earned runs in five of its last eight games played

Dylan Cease has made his case to win the A.L. Cy Young Award. However, let's not sleep on Ryan Weathers. The Yankees' southpaw has held the past five lineups he's faced to 3 earned runs, including a pair of shutouts

There's a reason the run total sits so low at 6.5. However, I'm willing to take plus odds on the under, with the best line available at +105 odds on Caesars.

📡 SBR Edge: Bronx Bombers going Under

The run total under has cashed in seven of the Yankees' last eight games played. Blue Jays and Yankees have also gone Under 6.5 total runs in three of previous four H2H matchups. 


🔥 Best Blue Jays vs. Yankees player prop bet

Heliot Ramos Under 1.5 hits + runs + RBIs (-160)

This is my second time fading Heliot Ramos in a couple-week stretch. He's really struggled at the plate in a Yankees uniform since being traded from the Giants.

He's gone Under 1.5 hits + runs + RBIs in three of his past five starts. Now, Ramos is being priced accordingly at -160 odds due to his lack of production. Facing Cease won't help his bat, as the Blue Jays starter held the Yankees to two hits and 2 earned runs in 6.1 innings pitched on August 16. 

Let's continue to fade Ramos as a batter and lay -160 odds on Under 1.5 hits + runs + RBIs at BetMGM.


💣 Blue Jays vs. Yankees home run prediction

Trent Grisham to hit a home run (+500)

Trent Grisham has been carrying the pail for the Yankees' lineup without stars like Aaron Judge and Cody Bellinger in the lineup. Grisham has recorded six of his 17 home runs in August and now benefits from playing in a hitter-friendly ballpark like Yankee Stadium.

Hitting metrics back Grisham's production. He's ranked in the 72nd percentile in xSLG (.439) and 78th in hard-hit percentage (46.2) in 2026. Grisham is also a crisp 97th percentile for squared-up percentage (35.2) and disciplined, sitting 98th in chase percentage (18.8) this year. 

Let's head to bet365 and place a wager on his home run prop at +500 odds. 


🚀 Blue Jays vs. Yankees same-game parlay

The NRFI has hit in four consecutive starts for Weathers, including consecutive starts for Cease. Extra Innings have occurred once in both of these teams' last five games played, which featured Cease and Weathers. It's unlikely to happen again, so bet this SGP at -127 odds on BetMGM. 

💵 Blue Jays vs. Yankees SGP picks

  • NRFI (-160)
  • Extra Innings: No (-1000)

Best odds: -127 via BetMGM (1.27u -> 1u)


💵 My betting record for MLB picks

All MLB picks, including SGPs, have been tracked since May 31.

Bet type Record Net profit ROI
Overall 53-104-3 -17.45 units ❌ -11.4% ❌
Game picks 18-19-2 -0.58 units ❌ -1.49% ❌
Player props 20-62-1 -11.10 units ❌ -17.7% ❌
Parlays 15-23 -5.77 units ❌ -17.0% ❌

💡 How I'm betting Blue Jays vs. Yankees: MLB strategy

Follow all of our MLB analysis and expert predictions for baseball season.

I'm staking 7.52 units across four bets in today's Blue Jays vs. Yankees matchup to win 6.85 units. It starts with a 2-unit play on Under 6.5 at +105 odds. Then, a max 4-unit bet on Heliot Ramos to finish Under 1.5 Hits+Runs+RBIs to win 2.5 units. 

A smaller 0.25 unit wager on Trent Grisham's +500 home run prop is followed up by a 1.27 unit bet on a two-leg SGP featuring NRFI/Extra Innings: No game game props to win 1 final unit of profit.  


📊 Live Blue Jays vs. Yankees odds

The Yankees have shortened from -122 to -104 in moneyline betting markets since opening, while the run total has dipped from 7.0 to 6.5. 

Public money is split evenly on either side in this game, with 70 percent of run line bets (+1.5) on the Yankees. Over 6.5 is drawing 63 percent of action from public bettors. 


📈 Blue Jays vs. Yankees betting trends

Blue Jays Statistic Yankees
63-67 W-L record 73-55
67-63 Run line record 66-62
64-62-4 O/U record 51-72-5
6-4 Last 10 games 7-3
3.96 Team ERA 3.20
.245 Team batting avg. .230
.685 OPS .715

🚑 Blue Jays vs. Yankees injuries


📺 How to watch Blue Jays vs. Yankees

  • Date: Saturday, Aug. 22
  • First pitch: 1:35 p.m. ET
  • Ballpark: Yankee Stadium (Bronx, N.Y.)
  • Streaming: ESPN Unlimited, MLB.TV
  • Blue Jays starter: Dylan Cease (7-5, 2.42 ERA)
  • Yankees starter: Ryan Weathers (5-7, 3.56 ERA)