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Chiefs vs. Buccaneers Prediction, Picks & Best Bets: NFL Preseason Week 2 Odds

Kansas City looks to halt its seven-game preseason losing streak as we provide our Chiefs vs. Buccaneers prediction for Saturday night's exhibition matchup.

Liam Fox

Last Updated: August 22, 2026 9:19 AM EDT • 3 minute read

Pictured: Tampa Bay Buccaneers quarterback Baker Mayfield throws a pass as we break down our Chiefs vs. Buccaneers prediction. Photo by Jay Biggerstaff via Imagn Images.

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We're expecting to see Baker Mayfield for the first time this preseason as his Tampa Bay Buccaneers host the Kansas City Chiefs on Saturday. My Chiefs vs. Buccaneers prediction fades a Kansas City squad that has routinely failed to show up across the last few summers.

Kickoff is scheduled for 7:30 p.m. ET on Saturday at Raymond James Stadium in Tampa, Fla. (ESPN Unlimited), with the Buccaneers priced as a 5.5-point home betting favorite.

🏈 Chiefs vs. Buccaneers prediction: NFL preseason Week 2

See the latest NFL odds and our experts' NFL picks for every game this season.

💰 Pick	⚖️ Units	🧠 Why I bet this
Buccaneers -5.5 (-108 via DraftKings)	0.6u → 0.56u	Chiefs have lost 7 straight preseason games by average of 8.14 points.
Over 37.5 (-102 via DraftKings)	0.4u → 0.39u	K.C. is 8-2 to the Over in their last 10 preseason games.

Total wagered: 1 unit | Max profit: 0.95 units

💰 Chiefs vs. Buccaneers best bet

Buccaneers -5.5 (-108)

The Chiefs practically mail it in when it comes to the preseason. Kansas City hasn't won an exhibition contest since 2023, losing the last seven preseason games by an average of 8.14 points.

Meanwhile, the Buccaneers are 5-2 over that stretch following last week's eight-point victory over the Jets. I'm backing the Bucs to cover the 5.5-point spread at home against a Chiefs team that seems to be looking ahead to the regular season. DraftKings offers the top value among the best sports betting sites at -108.

Score prediction: Buccaneers 24, Chiefs 14

🚀 Chiefs vs. Buccaneers same-game parlay

I'm combining my best bets for the matchup into a 2-leg parlay at +281 odds at DraftKings. There have been two clear trends with the Chiefs over the last few preseasons: Losing and giving up a ton of points in the process. That's why I have the Bucs covering the spread, and this game going Over its 37.5 total.

💵 Chiefs vs. Buccaneers SGP picks

Buccaneers -5.5
Over 37.5

Best odds: +281 via DraftKings (0.2u → 0.56u)

💵 My betting record for NFL picks

All NFL preseason picks, including SGPs, have been tracked since Aug. 7.

Bet type	Record	Net profit	ROI
Overall	6-5	+0.57 units ✅	14.25% ✅
Game picks	5-5	+0.32 units ✅	8.89% ✅
Player props	1-0	+0.25 units ✅	62.5% ✅

💡 How I'm betting Chiefs vs. Buccaneers: NFL preseason strategy

Follow all of our NFL analysis and betting advice for the 2026 NFL season.

It’s important not to get carried away with your bet sizes in the preseason. I’m only betting one unit total across my two favorite wagers for Chiefs vs. Buccaneers because there is so much uncertainty in the preseason surrounding player snap counts, play-calling, and other variables. My most confident play (Buccaneers -5.5) received the highest wager at 0.6 units, slightly above my other best bet. Bankroll management is crucial in sports betting, so be smart with yours.

📊 Chiefs vs. Buccaneers odds: NFL preseason Week 2

Our live Chiefs vs. Buccaneers odds update in real time.

🚑 Chiefs vs. Buccaneers latest injuries

📺 How to watch Chiefs vs. Buccaneers: NFL preseason Week 2

Date: Saturday, Aug. 22
Kickoff: 7:30 p.m. ET
Location: Raymond James Stadium (Tampa, Fla.)
Streaming: ESPN Unlimited

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Written by:
Liam Fox

Liam Fox is a Publishing Editor for Sportsbook Review. Liam spent the past seven-plus years in the sports media industry building his NFL experience and contributing at some of North America's top outlets. His work has appeared on Sportsnet, Forbes, and Complex. He was previously an editor for nearly four years at theScore, specializing in NFL coverage. His career highlights include asking Patrick Mahomes a question at Super Bowl LV media day and shedding light on the champion Philadelphia Eagles' use of analytics through an in-depth interview with their lead data analyst. A graduate of Carleton University's Bachelor of Journalism program, you can usually find Liam writing about sports, watching sports, or playing sports.