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San Francisco 49ers wide receiver Deebo Samuel runs after a catch as we look at our best Week 1 NFL predictions
San Francisco 49ers wide receiver Deebo Samuel runs after a catch. Photo by: Darren Yamashita/Imagn Images.

With the early Week 1 Sunday games underway, we're keen on seeing what happens while also focusing on the best action to get behind for Monday Night Football. 

The 2024-25 NFL season kicked off Thursday as the Kansas City Chiefs emerged victorious over the Baltimore Ravens in a battle of 2025 Super Bowl odds favorites, and it didn't disappoint.

The Kansas City Chiefs were the first team in the win column this season, and the Philadelphia Eagles followed suit by disposing of the Green Bay Packers in Brazil on Friday.

Week 1 concludes with Monday Night Football, featured in our Jets vs. 49ers prediction and Jets vs. 49ers player props

NFL picks & predictions Week 1

Don't miss the rest of our Week 1 NFL picks.

NFL odds for Monday

Jets vs. 49ers odds

Breece Hall anytime touchdown scorer (+130 via FanDuel) ⭐⭐⭐

Pick made by Mike Spector.

  • When: Monday, Sept. 9 - 8:20 p.m. ET
  • Where: Levi's Stadium, Santa Clara, Calif.
  • How to watch: ESPN, ABC
  • Moneyline: Jets (+165) | 49ers (-200)
  • Spread: Jets +3.5 (-105) | 49ers -3.5 (-115)
  • Total: 43.5 (-110/-110)

NFL picks roundup: Week 1

NFL feature picks

NFL betting odds pages

Here are our best NFL betting sites:

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