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NFL Predictions Week 1: Picks & Odds for Marquee Games

Esten McLaren

Last Updated: September 9, 2024 2:27 PM EDT • 1 min 37 sec read.

San Francisco 49ers wide receiver Deebo Samuel runs after a catch as we look at our best Week 1 NFL predictions
San Francisco 49ers wide receiver Deebo Samuel runs after a catch. Photo by: Darren Yamashita/Imagn Images.

With the early Week 1 Sunday games underway, we're keen on seeing what happens while also focusing on the best action to get behind for Monday Night Football. 

The 2024-25 NFL season kicked off Thursday as the Kansas City Chiefs emerged victorious over the Baltimore Ravens in a battle of 2025 Super Bowl odds favorites, and it didn't disappoint.

The Kansas City Chiefs were the first team in the win column this season, and the Philadelphia Eagles followed suit by disposing of the Green Bay Packers in Brazil on Friday.

Week 1 concludes with Monday Night Football, featured in our Jets vs. 49ers prediction and Jets vs. 49ers player props. 

NFL picks & predictions Week 1

Don't miss the rest of our Week 1 NFL picks.

NFL odds for Monday

Jets vs. 49ers odds

Breece Hall anytime touchdown scorer (+130 via FanDuel) ⭐⭐⭐

Pick made by Mike Spector.

  • When: Monday, Sept. 9 - 8:20 p.m. ET
  • Where: Levi's Stadium, Santa Clara, Calif.
  • How to watch: ESPN, ABC
  • Moneyline: Jets (+165) | 49ers (-200)
  • Spread: Jets +3.5 (-105) | 49ers -3.5 (-115)
  • Total: 43.5 (-110/-110)

NFL picks roundup: Week 1

NFL feature picks

NFL betting odds pages

Super Bowl OddsNFL MVP OddsNFL Offensive Player of the Year Odds
NFL Defensive Player of the Year OddsNFL Offensive Rookie of the Year OddsNFL Defensive Rookie of the Year Odds
NFL Coach of the Year OddsNFL Comeback Player of the Year OddsNFL Win Totals Odds
NFL Playoff OddsNFL Draft Odds

Here are our best NFL betting sites:

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Written By:
Esten McLaren
Esten is the Senior Publishing Editor for SportsbookReview.com. He has been in the sports betting industry since the legalization of mobile sports betting in New Jersey, and with SportsbookReview prior to the launch of sports betting in Ontario. Esten's previous stops include the USA TODAY network, including GolfWeek. He previously worked in the fantasy sports industry, with FNTSY Sports Network, theScore, and USA TODAY. Esten graduated from the College of Sports Media with a diploma in Radio and Television Sports Broadcasting after acquiring a degree in Biological Sciences from the University of Guelph. He has appeared on FNTSY Sports Network, VSiN, and VSiN's Long Shots podcast, where he correctly called Will Zalatoris as the winner of the 2022 FedEx St. Jude Championship. Esten is a big proponent of the entertainment side of sports betting and loves to dip his toes into the novelty and alt-markets while chasing long shots with reduced wagers on golf outrights and futures markets. He's also been known to sprinkle some lunch money on touchdown-scorer parlays with two notable hits still funding his bankroll. Esten looks at sports betting much like golf and advises beginner bettors to compete against themselves rather than being concerned with what others may or may not be doing based on social media claims.