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San Francisco 49ers running back Christian McCaffrey runs the ball pressured against the Baltimore Ravens in the second quarter at Levi's Stadium as we look at our Christian McCaffrey MNF Player Prop Bets.
San Francisco 49ers running back Christian McCaffrey runs the ball pressured against the Baltimore Ravens in the second quarter at Levi's Stadium. Photo by Cary Edmondson/Imagn Images

The San Francisco 49ers open up their season as Monday Night Football home favorites over the New York Jets. They're also among the leading contenders in the Super Bowl odds.

Looking at the Monday Night Football odds, the success of our Christian McCaffrey MNF player prop bets will come down to whether the 49ers take care of business against a Jets team that's much better than a season ago. 

McCaffrey ran for 1,459 yards and 14 touchdowns last season while adding another 564 yards and seven touchdowns as a receiver. He also ran for over 100-plus yards seven times.

Is he in for a huge night against a defense that gave up 124 rushing yards per game a year ago?

Editor's note: McCaffrey was ruled out for Week 1 with a calf/Achilles injury. The news broke roughly an hour before kickoff.

Christian McCaffrey prop predictions for Monday Night Football

NFL odds as of Monday and subject to change. Track the NFL scores for the latest line movement and matchup info.

Christian McCaffrey player props

NFL picks made Monday; odds subject to change.

Christian McCaffrey Under 73.5 rushing yards (-113) ⭐⭐⭐

This number just keeps dropping. It was at 77.5 yards through nearly all of our best sportsbooks on Sunday night. Now it’s down to 72.5 at every major sportsbook except for FanDuel.

Because FanDuel’s price is only slightly worse than what’s being offered at the other four leading options, take the extra yard to ensure a victory.

Many are going to look at last season’s stats and think this is an obvious time to take the Over. And while the Jets’ run defense was bad last year, a lot of that was tied to the terrible play of the club's offense.

The defense was repeatedly forced back onto the field fast, and the unit was exhausted in every game. Also, opponents could just run while always holding a lead.

The Jets' run defense will be better this season. Even though McCaffrey cleared this total in 14 games last year, including three postseason contests, most of his damage tonight will be done in the screen game. The Jets’ defensive front will cause problems for the 49ers' rushing attack. New York's offense will also sustain drives, keeping McCaffrey off the field for long stretches.

Rodrigo Villagomez believes a defensive slugfest is coming too as part of his Jets vs. 49ers player props.

Best odds: -113 via FanDuel | Implied probability: 53.05%

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Christian McCaffrey first touchdown scorer (+360) ⭐⭐⭐

DraftKings is listing the price for this prop at +360, while FanDuel and BetMGM are offering +350. The value drops off beyond those options at our best sports betting apps. Caesars features the price at +290.

McCaffrey, who's one of the leading contenders in the Offensive Player of the Year odds, has been great at finding the end zone throughout his career, and last season was no different. He ended the year with 21 regular-season touchdowns, then added five more in the playoffs. The tailback scored in 16 of his 19 games.

McCaffrey is very likely to find the end zone in this outing, and New York will probably be settling for a lot of field goals.

Meanwhile, Mike Spector is eyeing a running back on the opposite sideline to score in his Jets vs. 49ers prediction.

Best odds: +360 via DraftKings | Implied probability: 21.74%

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Christian McCaffrey Over 4.5 receptions (-105) ⭐⭐⭐⭐

If the 49ers struggle to run the ball in this contest, they’re going to still find ways to get McCaffrey involved in the offense. He finished with five-plus catches in 12 of his 19 games last season, including in all three of his postseason contests. 

Some of our best sports betting sites are offering this Over for -125. That's a fair price, but not nearly as valuable as BetMGM's odds. A price of -105 implies a probability of 51.22%. Considering McCaffrey’s past, there's certainly a better chance than that of him hitting this Over.

The most significant concern with this prop is that the 49ers blow the Jets out. However, I expect this affair to be close throughout with Aaron Rodgers on the other side, which is why this is a four-star play.

Best odds: -105 via BetMGM | Implied probability: 51.22%

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Jets vs. 49ers odds

Monday Night Football game info

  • Matchup: Jets vs. 49ers
  • Kickoff: 8:15 p.m. ET
  • Where: Levi’s Stadium, Santa Clara, CA
  • How to watch: ESPN/ABC/ESPN+
  • Weather: 57 degrees, 1% chance of precipitation, wind 6 mph
  • Favorite: 49ers (-198 via FanDuel)

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