Broncos vs. Chiefs Prediction: Week 1 Odds, Picks & Best Bet
Last Updated: September 13, 2026 10:30 AM EDT • 2 minute read X Social Google News Link
Despite the first Monday Night Football game of the season featuring the return of two prominent No. 1 starting quarterbacks, I’m backing the Under in my Broncos vs. Chiefs prediction.
The Chiefs are the 2.5-point betting favorite for the tilt at Arrowhead Stadium in Kansas City, Mo. (8:15 p.m. ET, ABC).
Let’s get into the reasons why points should be at a premium in this AFC West showdown.
🏈 Broncos vs. Chiefs picks & predictions
See all of our experts' NFL picks for Week 1 based on the latest NFL odds.
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💰 Broncos vs. Chiefs prediction & best bet
Check out all of our NFL picks for more analysis across this week's slate.
Under 43.5 (-108 via BetMGM)
I’m all for the Under in the first Monday Night Football game of the season. Both No. 1 quarterbacks will make their long-anticipated returns, with Patrick Mahomes playing his first game since tearing his ACL and LCL in December and Bo Nix fracturing his ankle in the January playoff victory over the Buffalo Bills.
Even without factoring in the accrued rust, neither offense was particularly expansive or free-flowing last season. And the Broncos’ defense, which is almost entirely intact from last season, had the fifth-best defensive DVOA.
Despite it being the season opener, a lot is on the line for these rivals, and neither will want to make a catastrophic mistake. I expect a defensive slugfest, with the Broncos snatching a fourth straight victory against the Chiefs.
📡 SBR Edge: Chiefs low-scoring home games
Last season, the Chiefs were 8-1 to the Under at Arrowhead Stadium, and they’re facing a Broncos defense that should be in the top five again this season.
Broncos vs. Chiefs Under trend
While trends do not usually sway me, the previous six meetings between the Chiefs and Broncos finished with 41 points or fewer. Mahomes and Nix will take some time to get their swagger back, and the Chiefs won’t be at the peak of their offensive power for a few weeks.
Score prediction: Broncos 21, Chiefs 20
📊 Broncos vs. Chiefs odds
See the latest NFL odds for every Week 1 matchup.
Broncos vs. Chiefs opening odds
- Moneyline: Broncos +115 | Chiefs -140
- Spread: Broncos +2.5 (-108) | Chargers -2.5 (-110)
- Over/Under: Over 43.5 (-110) | Under 43.5 (-108)
📺 How to watch Broncos vs. Chiefs: Week 1
- Date: Monday, Sept. 14
- Kickoff: 8:15 p.m. ET
- Location: Arrowhead Stadium (Kansas City)
- TV: ESPN & ABC
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