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Cincinnati Bengals quarterback Joe Burrow fakes a hand off as we look at our NFL Week 3 predictions.
Cincinnati Bengals quarterback Joe Burrow fakes a hand off. Photo credit: Sam Greene/The Enquirer / USA TODAY NETWORK via Imagn Images.

NFL Week 3 is when teams start to head in separate directions.

The first two weeks are for testing the waters. We, as bettors, are able to get a better sense of our offseason expectations and either be pleasantly surprised or rightfully disappointed.

Week 3 was time for those with any true Super Bowl odds hopes to right the ship or put the hammer down. The Buffalo Bills and Cincinnati Bengals will hope to do little both as favorites by the Monday Night Football odds

With two games remaining on Monday night, Esten McLaren makes a pair of anytime touchdown scorer predictions for Monday Night Football.

Get ready for the week ahead with our breakdown of the NFL Week 4 odds from our best NFL betting sites, including Mike Spector's Cowboys vs. Giants early picks for TNF.

NFL picks & predictions Week 3

Our NEW NFL player prop odds tool can help you find the best odds on any market across legal sportsbooks in your area!

Don't miss the rest of our Week 3 NFL picks, including the first touchdown scorer predictions for Monday Night Football. Listed odds for all games via bet365 unless stated otherwise.

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NFL odds for Monday

Jaguars vs. Bills odds

Prediction: Travis Etienne anytime touchdown scorer (+110 via FanDuel) ⭐⭐⭐

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Pick made by Mike Spector.

  • When: Monday, Sept. 23 - 7:30 p.m. ET
  • Where: Highmark Stadium, Orchard Park, N.Y.
  • How to watch: ESPN
  • Moneyline: Jaguars +210 | Bills -260
  • Spread: Jaguars +5.5 (-110) | Bills -5.5 (-110)
  • Total: 46 (-110/-110)

Commanders vs. Bengals odds

Prediction: Zack Moss Over 13.5 rushing attempts (-102 via FanDuel) ⭐⭐⭐

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Pick made by Mike Spector.

  • When: Monday, Sept. 23 - 8:15 p.m. ET
  • Where: Paycor Stadium, Cincinnati
  • How to watch: ABC
  • Moneyline: Commanders +310 | Bengals -390
  • Spread: Commanders +8 (-110) | Bengals -8 (-110)
  • Total: 48 (-110/-110)

NFL picks roundup: Week 3

NFL feature picks

NFL betting odds pages

Here are our best NFL betting sites:

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