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Tua Tagovailoa of the Miami Dolphins features in our Week 4 Odds and Lines
Tua Tagovailoa of the Miami Dolphins throws a pass against the Jacksonville Jaguars at TIAA Bank Field on Aug. 26, 2023 in Jacksonville, Florida. Photo by Rich Storry/Getty Images via AFP.

Week 4 of the NFL features an AFC East rivalry game between two of the top Super Bowl contenders in the AFC, so let's examine the Week 4 odds and betting lines from our best NFL betting sites.

Week 4 of the NFL season is filled with several rivalry games that will play a significant role in determining division winners. On Thursday Night Football, we have the Detroit Lions visiting Lambeau Field to face the Green Bay Packers in a rematch of last season's Week 18 game, which the Lions won, eliminating the Packers from the playoffs.

On Sunday afternoon, the Miami Dolphins will visit Highmark Stadium to take on the Buffalo Bills, a matchup I consider the highlight of Week 4. According to the lookahead line, the Bills are favored by 2.5 points over the Dolphins, a number certain to generate considerable interest on both sides.

Let's take a closer look at all the other opening odds for Week 4 of the NFL season via our best sports betting apps.

NFL Week 4 odd and lines

When betting on NFL markets, there's an advantage in getting to these NFL odds early and trying to beat any line movements. The closer you wait until Sunday to make your NFL picks, the more difficult it becomes to identify edges and secure the best price on the outcome you wish to bet on.

That's why it's important to start monitoring the NFL opening odds each week as soon as possible. This proactive approach will contribute to your long-term success in your sports betting endeavors.

Best NFL Week 4 spreads

Odds via Caesars

GameOpening Spread (Sept. 20)Spread (Sept. 25)
Lions vs. PackersPickLions -2
Falcons vs. JaguarsJaguars -3Jaguars -3
Rams vs. ColtsRams -1Colts -1 (-105)
Buccaneers vs. SaintsSaints -3.5Saints -3
Commanders vs. EaglesEagles -7Eagles -7
Steelers vs. Texans Steelers -4Steelers -3.5 (-105)
Bengals vs. TitansBengals -1Titans -1.5
Ravens vs. BrownsRavens -1.5Browns -2
Broncos vs. BearsBroncos -2Broncos -3.5
Dolphins vs. BillsBills -3Bills -2.5  (-120)
Vikings vs. PanthersVikings -3Vikings -3
Raiders vs. ChargersChargers -4.5Chargers -4.5
Patriots vs. CowboysCowboys -7.5Cowboys -7
Cardinals vs. 49ers49ers -14.549ers -14
Chiefs vs. JetsChiefs -7Chiefs -9
Seahawks vs. GiantsSeahawks -1.5Seahawks -1.5

One spread that has moved since the opening line is the Baltimore Ravens being slight favorites over the Cleveland Browns on the road in Week 4. The Ravens initially opened as 1.5-point favorites over the Browns, but with the Ravens losing in overtime to the Indianapolis Colts and dealing with injuries, we now see the Browns trading as 2-point favorites.

Best NFL Week 4 moneylines

Odds via DraftKings

GameOpening Moneyline (Sept. 20)Moneyline (Sept. 25)
Lions vs. PackersPackers (-122)Lions (-118)
Falcons vs. JaguarsJaguars (-148)Jaguars (-155)
Broncos vs. BearsBroncos (-122)Broncos (-175)
Vikings vs. PanthersVikings (-130)Vikings (-148)
Rams vs. ColtsRams (-120)Rams (-110)
Buccaneers vs. SaintsSaints (-218)Saints (-148)
Commanders vs. EaglesEagles (-375)Eagles (-290)
Dolphins vs. BillsBills (-180)Bills (-142)
Bengals vs. TitansBengals (-118)Titans (-122)
Ravens vs. BrownsRavens (-120)Browns (-120)
Steelers vs. Texans Steelers (-198)Steelers (-170)
Raiders vs. ChargersChargers (-225)Chargers (-205)
Patriots vs. CowboysCowboys (-360)Cowboys (-285)
Cardinals vs. 49ers49ers (-950)49ers (-850)
Chiefs vs. JetsChiefs (-360)Chiefs (-395)
Seahawks vs. GiantsSeahawks (-115)Seahawks (-120)

It's only Week 4 of the NFL season, and we already have a -850 favorite on the moneyline. But buyer beware, these very same Arizona Cardinals just defeated the Dallas Cowboys in Week 3. The Cardinals will travel to Levi's Stadium in Week 4 to face the San Francisco 49ers, and while we initially thought they were tanking for USC QB Caleb Williams, it appears the Cardinals might be better than we anticipated. The Cardinals are catching 14 points on the spread and are trading at +575 on the moneyline to win the game. Both lines have slightly shifted in their favor following their Week 3 victory over the Cowboys.

The 49ers aren't the only massive favorites on the moneyline in Week 4; the Kansas City Chiefs are also -395 favorites against the New York Jets on Sunday Night Football. We were robbed of an exciting primetime matchup when Aaron Rodgers suffered an Achilles injury in Week 1. With Zach Wilson at quarterback for the Jets, the announcers should have plenty of time in the fourth quarter to talk about Taylor Swift and Travis Kelce.

Best NFL Week 4 Over/Unders

Odds via bet365

GameOpening Over/Under (Sept. 20)Over/Under (Sept. 25)
Lions vs. Packers46.5 (-110/-110)45 (-110/-110)
Falcons vs. Jaguars45.5 (-110/-110)43.5 (-110/-110)
Ravens vs. Browns44.5 (-110/-110)41.5 (-110/-110)
Bengals vs. Titans44 (-110/-110)42.5 (-110/-110)
Broncos vs. Bears44.5 (-110/-110)46 (-110/-110)
Rams vs. Colts45 (-110/-110)45 (-110/-110)
Dolphins vs. Bills49.5 (-110/-110)53.5 (-110/-110)
Vikings vs. Panthers44.5 (-110/-110)45 (-110/-110)
Steelers vs. Texans40.5 (-110/-110)41 (-110/-110)
Buccaneers vs. Saints41 (-110/-110)40.5 (-110/-110)
Commanders vs. Eagles 44.5 (-110/-110)44.5 (-110/-110)
Raiders vs. Chargers49.5 (-110/-110)50.5 (-110/-110)
Cardinals vs. 49ers41 (-110/-110)42 (-110/-110)
Patriots vs. Cowboys42.5 (-110/-110)41.5 (-110/-110)
Chiefs vs. Jets45 (-110/-110)42.5 (-110/-110)
Seahawks vs. Giants45 (-110/-110)45 (-110/-110)

The Dolphins-Bills matchup boasts the highest total for Week 4, as it moved from the opening line of 49.5 to 53.5, thanks to the Dolphins' 70-point outburst against the Denver Broncos in Week 3. On the lookahead lines, we didn't have a single total exceeding 50 points, but the Raiders-Chargers game has also moved into the 50s.

NFL betting odds pages

Here are our best NFL betting sites:

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