College Football Week 4 Predictions: Picks & Odds for Marquee Games
Unlike last week's slate, Week 4 has some heavy hitters with several conference games between AP Top 25 programs.
Our college football Week 4 odds and predictions look at the top games, including Tennessee vs. Oklahoma, as Nico Iamaleava looks to bolster his Heisman Trophy odds in his first SEC start.
While that's the biggest game on the schedule, Utah vs. Oklahoma State will have a massive impact on the College Football Playoff odds as both programs fight to climb the Big 12 standings.
And of course, USC vs. Michigan is a battle of two blue bloods with fanbases who expect their teams to be among the college football championship odds favorites.
The Wolverines are an underdog at our college football betting sites in USC's first conference game as a member of the Big Ten. I like Michigan with my college football Week 4 against the spread picks.
College football picks & predictions Week 4
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- Tennessee vs. Oklahoma early picks
- Arch Manning player prop bets
- Baylor vs. Colorado prediction
- Kansas State vs. BYU prediction
Don't miss the rest of our Week 4 college football picks.
College football odds for Saturday
College football odds via DraftKings and subject to change. Follow the latest college football scores for line history and matchup info.
Utah vs. Oklahoma State odds
Prediction: Ollie Gordon II Under 85.5 rushing yards (-118 via Caesars) ⭐⭐⭐
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Pick made by Phil Wood
- When: Saturday, Sept. 21 (4 p.m. ET)
- Where: Boone Pickens Stadium (Stillwater, Okla.)
- How to watch: FOX
- Moneyline: Utah (-130) | Oklahoma State (+110)
- Spread: Utah -2.5 (-110) | Oklahoma State +2.5 (-110)
- Total: 52 (-108/-112)
Tennessee vs. Oklahoma odds
Prediction: Dylan Sampson Over 86.5 rushing yards (-114 via FanDuel) ⭐⭐⭐⭐
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Pick made by Brenden Schaeffer.
- When: Saturday, Sept. 21 (7:30 p.m. ET)
- Where: Memorial Stadium (Norman, Okla.)
- How to watch: ABC
- Moneyline: Tennessee (-265) | Oklahoma (+215)
- Spread: Tennessee -7 (-115) | Oklahoma +7 (-105)
- Total: 57.5 (-110/-110)
Baylor vs. Colorado odds
Prediction: Travis Hunter Under 94.5 receiving yards (-115 via bet365) ⭐⭐⭐⭐
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Pick made by Mike Spector.
- When: Saturday, Sept. 21 (8 p.m. ET)
- Where: Folsom Field (Boulder, Colo.)
- How to watch: FOX
- Moneyline: Baylor (+110) | Colorado (-130)
- Spread: Baylor +2 (-110) | Colorado -2 (-110)
- Total: 52.5 (-112/-108)
Kansas State vs. BYU odds
Prediction: DJ Giddens Over 17.5 rushing attempts (-115 via bet365) ⭐⭐⭐⭐
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Pick made by Mike Spector.
- When: Saturday, Sept. 21 (10:30 p.m. ET)
- Where: LaVell Edwards Stadium (Provo, Utah)
- How to watch: ESPN
- Moneyline: Kansas State (-250) | BYU (+205)
- Spread: Kansas State -7 (-108) | BYU +7 (-112)
- Total: 47.5 (-110/-110)
College football picks roundup: Week 4
- College football expert picks Week 4
- College football player props Week 4
- College football against the spread picks Week 4
- College football upset picks Week 4
- College football predictions & best bets Week 4
- SEC predictions
- Big 12 predictions
- Big Ten predictions
College football betting odds pages
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- BetMGM Bonus Code: SBRBONUS | Read our BetMGM Review
- bet365 Bonus Code: SBRBONUS | Read our bet365 Review
- FanDuel Promo Code | Read our FanDuel Review
- DraftKings Promo Code | Read our DraftKings Review
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