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Oklahoma wide receiver Deion Burks reacts after scoring against Temple. We breakdown Oklahoma's showdown with Tennessee in our college football predictions for Week 4.
Oklahoma wide receiver Deion Burks reacts after scoring against Temple. Photo by Kevin Jairaj via Imagn Images.

Unlike last week's slate, Week 4 has some heavy hitters with several conference games between AP Top 25 programs.

Our college football Week 4 odds and predictions look at the top games, including Tennessee vs. Oklahoma, as Nico Iamaleava looks to bolster his Heisman Trophy odds in his first SEC start.

While that's the biggest game on the schedule, Utah vs. Oklahoma State will have a massive impact on the College Football Playoff odds as both programs fight to climb the Big 12 standings. 

And of course, USC vs. Michigan is a battle of two blue bloods with fanbases who expect their teams to be among the college football championship odds favorites.

The Wolverines are an underdog at our college football betting sites in USC's first conference game as a member of the Big Ten. I like Michigan with my college football Week 4 against the spread picks.

College football picks & predictions Week 4

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Don't miss the rest of our Week 4 college football picks.

College football odds for Saturday

College football odds via DraftKings and subject to change. Follow the latest college football scores for line history and matchup info.

Utah vs. Oklahoma State odds

Prediction: Ollie Gordon II Under 85.5 rushing yards (-118 via Caesars) ⭐⭐⭐

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Pick made by Phil Wood

  • When: Saturday, Sept. 21 (4 p.m. ET)
  • Where: Boone Pickens Stadium (Stillwater, Okla.)
  • How to watch: FOX
  • Moneyline: Utah (-130) | Oklahoma State (+110)
  • Spread: Utah -2.5 (-110) | Oklahoma State +2.5 (-110)
  • Total: 52 (-108/-112)

Tennessee vs. Oklahoma odds

Prediction: Dylan Sampson Over 86.5 rushing yards (-114 via FanDuel) ⭐⭐⭐⭐

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Pick made by Brenden Schaeffer.

  • When: Saturday, Sept. 21 (7:30 p.m. ET)
  • Where: Memorial Stadium (Norman, Okla.)
  • How to watch: ABC
  • Moneyline: Tennessee (-265) | Oklahoma (+215)
  • Spread: Tennessee -7 (-115) | Oklahoma +7 (-105)
  • Total: 57.5 (-110/-110)

Baylor vs. Colorado odds

Prediction: Travis Hunter Under 94.5 receiving yards (-115 via bet365) ⭐⭐⭐⭐

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Pick made by Mike Spector.

  • When: Saturday, Sept. 21 (8 p.m. ET)
  • Where: Folsom Field (Boulder, Colo.)
  • How to watch: FOX
  • Moneyline: Baylor (+110) | Colorado (-130)
  • Spread: Baylor +2 (-110) | Colorado -2 (-110)
  • Total: 52.5 (-112/-108)

Kansas State vs. BYU odds

Prediction: DJ Giddens Over 17.5 rushing attempts (-115 via  bet365) ⭐⭐⭐⭐

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Pick made by Mike Spector.

  • When: Saturday, Sept. 21 (10:30 p.m. ET)
  • Where: LaVell Edwards Stadium (Provo, Utah)
  • How to watch: ESPN
  • Moneyline: Kansas State (-250) | BYU (+205)
  • Spread: Kansas State -7 (-108) | BYU +7 (-112)
  • Total: 47.5 (-110/-110)

College football picks roundup: Week 4

College football betting odds pages

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