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It was a nightmare Week 1 for Buffalo Bills quarterback Josh Allen, and we’re looking at whether the two-time Pro Bowler can sharpen up in our top Raiders vs. Bills predictions based on the latest NFL NFL odds from our best sports betting apps.

Buffalo Bills quarterback Josh Allen turned the ball over four times in losing fashion last week, and the New York Jets pulled off the victory with their own No. 1 quarterback Aaron Rodgers (Achilles) leaving the game before even completing a pass.

Perhaps, most telling was Allen connected on more throws with ets’ safety Jordan Whitehead than to his own No. 2 wide receiver Gabe Davis.

Against the 1-0 Las Vegas Raiders, can Allen dial it in for Buffalo’s home opener to put the Bills back on track?

Here is our best Raiders vs. Bills prediction and NFL best bets for Week 2, NFL upset picks and NFL player props (odds via our best NFL betting sites; pick confidence based on a 1-to-5-star scale).

Raiders vs. Bills prediction

Bills -8 (-110 via Caesars) ⭐⭐⭐⭐

Allen was a problem for the Bills in the team’s Week 1 loss to the Jets. Responsible for four turnovers, the Buffalo signal caller gave away too many short fields to win the game.

Unsurprisingly, it left the Bills ranked 23rd in overall efficiency per FPI heading into Week 2. The Raiders earned some credit in their road win at Denver, slotting in at 14th in overall efficiency. Raiders QB Jimmy Garoppolo deserves credit for guiding Vegas to an eighth-ranked offensive efficiency.

But the Raiders' defense ranks 26th in efficiency and Allen should exploit it now that he gets to experience some home cooking. A bounce-back performance by Allen, the type that led the Bills to outscore their first two opponents 72-17 to open the 2022 season, should mean value on the Bills in Week 2.

Buffalo found success when targeting wide receiver Stefon Diggs last week, but fellow WR Gabe Davis didn’t get very involved. The Raiders' secondary could be vulnerable to a big game from Davis, as most of their ability to limit Broncos signal caller Russell Wilson to 177 yards last week came as Russ dinked-and-dunked to RBs and TEs. Allen won’t approach it that way.

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Raiders vs. Bills best odds

Caesars (-110)

DraftKingsFanDuelBetMGMCaesarsbet365
Bills -8.5Bills -8.5Bills -8.5Bills -8Bills -8.5
-110-105-110-110-110

As long as Caesars continues offering the Bills at -8 with standard -110 odds, that’s the best option for this wager of our best sports betting apps. FanDuel’s odds rank next in quality, as you can score reduced -105 odds on the Bills -8.5 there.

The rest of our best sports betting sites feature Bills -8.5 at standard -110 odds, so try to place this wager somewhere with better lines than that. Still, take the Bills comfortably up to -9.5 in this matchup.

Raiders vs. Bills odds

Raiders vs. Bills odds analysis

The Bills opened as 9.5-point favorites before seeing the line dip to -8 at the best sportsbooks. It’s now gaining momentum back the other way, with most shops sitting at Bills -8.5. More than 59% of point-spread wagers have come in on Buffalo.

The total opened at 47.5 before dipping to 47. More than 60% of wagers on the total are on the Over.

Raiders vs. Bills game info

  • When: Sunday, Sept. 17 at 1 p.m. ET
  • Where: Highmark Stadium, Orchard Park, NY
  • How to watch: CBS
  • Weather: 66 degrees, 26% chance of precipitation, 6-mph winds

Raiders-Bills prediction made Friday, 9/15/23 at 1 p.m. ET

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NFL Week 2 matchups

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