NFL Preseason Predictions & Odds Today: Expert Picks for Every Game Tonight

I hope you enjoyed the first three weeks of exhibition football, because our NFL predictions and odds today are the last before we officially kick off the regular season in just under two weeks' time.

Saturday's action kicks off at noon ET between I-95 rivals in the Washington Commanders and Baltimore Ravens, and it wraps up at 10 p.m. ET when the Las Vegas Raiders travel to face the Arizona Cardinals. We've compiled all of our expert picks and best bets as part of our NFL preseason Week 3 predictions.

🏈 Best NFL predictions today

🔎 Our NFL player prop odds tool can help you find the best NFL odds to make your NFL picks across legal sportsbooks in your region.

• Seahawks +3 (-105 via FanDuel) vs. Packers ⭐⭐⭐
• Dolphins -6 (-110 via BetMGM) vs. Jaguars ⭐⭐
• Buccaneers +2.5 (-105 via DraftKings) vs. Bills ⭐⭐⭐
• Chargers -1.5 (-102 via FanDuel) vs. 49ers ⭐⭐
• Cardinals +2.5 (-112 via DraftKings) vs. Raiders ⭐⭐

📖 Check out our 2025 NFL preseason betting guide for our best betting strategies and full NFL preseason schedule.

💰 NFL preseason odds & expert picks for every game

Here are the latest odds and our expert picks for every game via the best NFL betting sites, which update live in real time. Follow the latest NFL scores for line history and matchup info.

📊 Seahawks vs. Packers odds

• Date: Saturday, Aug. 23
• Kickoff: 4 p.m. ET
• Location: Lambeau Field (Green Bay, Wis.)
• How to watch: ABC

🔮 Seahawks vs. Packers prediction: Seahawks +3

Here's a sneak peek at why Isaiah Sirois believes the Seahawks will cover the spread:

"Even with Jalen Milroe under center, we like our chances with this Seahawks squad, especially against the Packers. Jordan Love hasn't taken the field since the opening week of the preseason due to injury, leaving the Packers with Malik Willis, Sean Clifford, and Taylor Elgersma."

👉 Check out his full analysis in our Seahawks vs. Packers prediction

📊 Jaguars vs. Dolphins odds

• Date: Saturday, Aug. 23
• Kickoff: 7 p.m. ET
• Location: Hard Rock Stadium (Miami)
• How to watch: NFL Network

🔮 Jaguars vs. Dolphins prediction: Dolphins -6

Here's a sneak peek at why Matt Jacob believes the Dolphins will win and cover the spread:

"No doubt, this is a hefty point spread for a preseason game. But if there’s one thing we know about the Miami Dolphins it’s that when they win preseason games, they tend to win them convincingly."

👉 Check out his full analysis in our Jaguars vs. Dolphins prediction

📊 Bills vs. Buccaneers odds

• Date: Saturday, Aug. 23
• Kickoff: 7 p.m. ET
• Location: Raymond James Stadium (Tampa, Fla.)
• How to watch: FOX

🔮 Bills vs. Buccaneers prediction: Buccaneers +2.5

Here's a sneak peek at why Phil Wood believes the Buccaneers will cover the spread:

"The Buccaneers aren’t playing their starters, but that's been the case at a lot of key positions this preseason, and they’re still 2-0. The offense is averaging 23 points per game, while the defense has given up just 21 total."

👉 Check out his full analysis in our Bills vs. Buccaneers prediction

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📊 Chargers vs. 49ers odds

• Date: Saturday, Aug. 23
• Kickoff: 8:30 p.m. ET
• Location: Levi's Stadium (Santa Clara, Calif.)
• How to watch: NFL+

🔮 Chargers vs. 49ers prediction: Chargers -1.5

Here's a sneak peek at why Isaiah Sirois believes the Chargers will cover the spread:

"The Chargers aren’t expected to deploy their starters, so we’re likely going to see a healthy amount of Trey Lance. That may be good in this spot. Lance - who was drafted by the 49ers in the first round of the 2021 NFL Draft - now gets a chance to somewhat settle the score."

👉 Check out his full analysis in our Chargers vs. 49ers prediction

📊 Raiders vs. Cardinals odds

• Date: Saturday, Aug. 23
• Kickoff: 10 p.m. ET
• Location: State Farm Stadium (Glendale, Ariz.)
• How to watch: NFL Network

🔮 Raiders vs. Cardinals prediction: Cardinals +2.5

Here's a sneak peek at why Matt Jacob believes the Cardinals will cover the spread:

"This pick isn’t about a strong belief in Arizona’s backups - who will be on the field for 60 minutes in this contest - as much as it’s a lack of faith in Las Vegas’ ability to win a preseason game. Because it hasn’t happened in more than two calendar years."

👉 Check out his full analysis in our Raiders vs. Cardinals prediction

❓ NFL betting FAQs

What does the spread mean in betting NFL?

In NFL betting, the spread is the number of points a team is favored to win or lose by. It levels the playing field for bettors by giving an advantage or disadvantage in points. Bettors win if their pick covers the spread.

Where can I find top NFL betting odds?

Make sure you look at our top NFL betting sites to find the best odds for the NFL. These sportsbooks include BetMGM, bet365, Caesars, FanDuel, and DraftKings.

🏆 NFL betting odds

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