Chiefs vs. Seahawks Prediction, Odds & Expert Picks: NFL Preseason Week 2

The Kansas City Chiefs and Seattle Seahawks meet on Friday on the West Coast, with one of the teams expected to give their starters some game time.

Gary Pearson

Last Updated: August 14, 2025 8:38 AM EDT • 4 minute read

Chiefs vs. Seahawks Prediction, Odds & Expert Picks: NFL Preseason Week 2 — Pictured: Sam Darnold in action at training camp as we offer our Chiefs vs. Seahawks Prediction. Photo by Stephen Brashear via Imagn Images

Friday's 10 p.m. ET nightcap from Lumen Field in Seattle features the Seattle Seahawks and Kansas City Chiefs (NFL Network). Mike Macdonald expressed his desire to provide playing time for most starters, which has influenced my Chiefs vs. Seahawks prediction.

The line flipped after Macdonald's disclosure, and the Seahawks are now the 3-point betting favorites at our best sports betting sites. The analysis below also discusses Andy Reid's intentions for the game, all of which are part of our NFL preseason Week 2 predictions.

🏈 Chiefs vs. Seahawks predictions & expert picks

🔎 Our NFL player prop odds tool can help you find the best NFL odds across legal sportsbooks in your area to make your NFL picks!

✅ Against the spread pick: Seahawks -3 (-105 via DraftKings) ⭐⭐⭐⭐
✅ My best bet: Over 38 (-110 via Caesars) ⭐⭐⭐⭐

🔮 Chiefs vs. Seahawks ATS prediction

🔵 Seahawks -3 ⭐⭐⭐⭐

📊 Best odds: -105 via DraftKings ($10 to win $9.52)
🔢 Implied probability: 51.22%

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To the delight of the feverish faithful at Lumen Field, most Seahawks' starters will get some game time. While I doubt Sam Darnold plays more than two series, any points he can put on the board will be a bonus as far as my Chiefs vs. Seahawks prediction is concerned.

After hearing that Andy Reid probably won't feature most of his starters, including Patrick Mahomes, I would have backed the Seahawks to cover the spread even if Darnold doesn't see the field.

With Gardner Minshew locked in as the team's backup QB, I expect Bailey Zappe and Chris Oladokun - who are battling to secure the third-string role - to carry the bulk of the load. Zapped by inaccuracy, Bailey tossed two picks in a ghastly 8-for-17 performance last week against the Arizona Cardinals.

Meanwhile, third-year signal-caller Oladokun was 6-for-13, finishing with 39 yards.

While it's certainly no lock, I'm more confident in Drew Lock's ability to move the ball, at least in the preseason and despite his pick against the Las Vegas Raiders. Jalen Milroe should also get plenty of reps, but I have more confidence in the rookie than I do Zappe, which speaks volumes.

📖 Check out our 2025 NFL preseason betting guide for the best betting strategies and full NFL preseason schedule.

💰 Chiefs vs. Seahawks best bet

⬆️ Over 38 ⭐⭐⭐⭐

📊 Best odds: -110 via Caesars ($10 to win $9.09)
🔢 Implied probability: 52.38%

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This Over is predicated on the Seahawks' ability to move the ball at home against a second-string Chiefs defense. I'm slightly concerned that Lock's time might be limited to facilitate additional minutes for Milroe.

However, I'm banking on Darnold to get the Seahawks on the scoresheet before his cameo concludes. And with Lock and Milroe under center, the Seahawks should do just enough to push the game over 38 points.

I hope Minshew plays for a few series before the Chiefs turn to Oladokun and Zappe, but I'm still confident, albeit to a lesser degree, if they don't.

Caesars is the only one of our best sports betting apps offering a total of 38. The rest offer 39 or 39.5. The difference in odds is almost negligible, with Caesars' -110 odds slightly shorter than FanDuel's -105 odds.

📊 Chiefs vs. Seahawks odds

Live updated odds from our best live betting sites. Follow the latest NFL scores for line history and matchup info.

🪧 Chiefs vs. Seahawks opening odds:

Chiefs: -2.5 (-110)
Seahawks: +2.5 (-110)

🚑 Chiefs vs. Seahawks injuries

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Written by:
Gary Pearson

Gary Pearson has written professionally since 2010, focusing on sports betting since 2014. Before entering the sports betting space, he contributed to the Canadian Press, FanSided, the Hockey Writers, the Calgary Herald, and other publications. His work has also been featured in Sports Illustrated and Bleacher Report. Gary, who consumes sports like a blue whale devours plankton, has a penchant for writing predictions and analyses across several sports, including hockey, soccer, football, tennis, and more. He bets regularly, preferring single-game picks, props, and live betting. While there isn't a sport he has yet to dabble in, Gary prefers betting on soccer, hockey, and football. He studied at various post-secondary institutions, including the University of Calgary, SAIT Polytechnic, and Griffith University, located in Brisbane, Australia. Gary has a marketing degree and completed his bachelor's degree in journalism at Griffith University. He feels strongly that life experience is as essential as post-secondary education, helping formulate more accurate predictions and analyses. Gary believes that competing at a high level of amateur sports during his formative years helped him better understand an athlete's psyche and the nuances and complexities of a team's dynamic, both on and off the playing surface. He feels that knowledge is immeasurably important when offering his analytical expertise. He has lived on five continents and currently resides in Canada.