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Justin Jefferson of the Minnesota Vikings scores a touchdown during the first quarter against the Green Bay Packers, and we offer our top predictions for Vikings vs. Panthers based on the best NFL odds.
Justin Jefferson of the Minnesota Vikings scores a touchdown during the first quarter against the Green Bay Packers. Photo by Stephen Maturen/Getty Images via AFP.

We anticipate a high-scoring affair in our Vikings vs. Panthers predictions, based on the best NFL odds.

Kirk Cousins leads the NFL in passing yards, but the Minnesota Vikings still find themselves at 0-3 thanks to untimely turnovers and a leaky defense.

Can Minnesota clinch their first victory as they travel as favorites to face another 0-3 team, the Carolina Panthers?

Here is our best Vikings vs. Panthers prediction and our NFL picks (odds via our best NFL betting sites; pick confidence based on a 1-to-5-star scale).

Make sure to check out all of our NFL predictions for Week 4.

Vikings vs. Panthers prediction

Over 46 (-109 via BetRivers) ⭐⭐⭐⭐

The Vikings’ average of 23 points per game makes them seem like a middle-of-the-pack offense, but don’t be fooled. Minnesota’s scoring output would look a whole lot better if it weren’t for a league-high seven lost fumbles and several red-zone turnovers in the first three weeks. Cousins leads the NFL in passing yards, Justin Jefferson already has 12 catches of 20-plus yards, and three other Vikings have caught at least two touchdown passes.

Minnesota should be able to finally finish drives against an injury-ravaged Carolina defense. Already without star linebacker Shaq Thompson due to a leg injury, the Panthers’ stop-unit took a couple of more hits last week when safety Xavier Woods and cornerback C.J. Henderson had to leave the game early. Henderson’s ailment is especially problematic since he would be one of Carolina’s top options to defend Jefferson.

The Panthers should be able to score here, as well. Minny’s defense has resembled a turnstile so far in 2023 under new coordinator Brian Flores, giving up 259 rushing yards in Week 2 against the Eagles and then 454 passing yards last week vs. the Chargers.

Rookie Bryce Young hasn’t looked good in his first two starts as a Panther, but those games came against much tougher defenses in New Orleans and Atlanta. Even with an ankle ailment that forced him to miss last week’s game against Seattle, Young should look better against the Vikings, and if he has to leave the game early, backup Andy Dalton is coming off a 361-yard performance against the Seahawks.

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Vikings vs. Panthers best odds

BetRivers (-109)

DraftKings FanDuel BetMGM Caesars bet365
46.5 46.5 46.5 46.5 46.5
-110 -110 -110 -110 -110

At the time of writing, 46.5 was the consensus total in the marketplace, including at all five of our best sports betting apps. BetRivers allows you to snag an extra half-point of value and a cent of juice by backing the Over 46 -109.

Vikings vs. Panthers odds

Vikings vs. Panthers odds analysis

The Vikings’ 0-3 start hasn’t prevented bettors from piling on Minnesota, betting the road team out from a 3-point favorite to as high as 4.5 before the line settled at 4. Minny’s moneyline odds also inflated accordingly, soaring north of -200 at most shops.

The Over saw plenty of early action, as well, going up from 44 to 46 within a couple of hours of opening.

Vikings vs. Panthers game info

  • When: Sunday, Oct. 1 at 1:00 p.m. ET
  • Where: Bank of America Stadium, Charlotte, NC
  • How to watch: FOX
  • Weather: 80 degrees, 0% chance of precipitation, 12 mph winds

Vikings-Panthers prediction made 09/29/2023 at 9:10 a.m. ET

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