Seahawks vs. 49ers Player Prop Bet Odds & Touchdown Picks: Geno Smith To Struggle Again In San Francisco

The Seattle Seahawks and San Francisco 49ers each look to pick up a key win in the NFC West race when the division rivals meet at 4:05 p.m. ET from Levi’s Stadium on Sunday afternoon. The 49ers sit fifth in the Super Bowl odds.

• San Francisco is 6-0 straight up and 5-1 against the spread in its last six games against Seattle
• Geno Smith has never helped to cover the spread or beaten the 49ers in five career starts
• Brock Purdy (5-0) and Joe Montana (2-0) are the only 49ers quarterbacks with zero losses in multiple starts against the Seahawks

Our Seahawks vs. 49ers player prop bets take into account that the 49ers are 6.5-point favorites in a game with a projected total of 48 points. Bettors and fans can watch it on FOX.

Seahawks vs. 49ers NFL player prop bets: Sunday

Odds as of Thursday and subject to change.

• Deebo Samuel touchdown pick: Anytime touchdown scorer (+140 via Caesars) ⭐⭐⭐
• Geno Smith Under 1.5 passing touchdowns (-130 via BetMGM) ⭐⭐⭐⭐
• Brock Purdy Over 254.5 passing yards (-115 via BetMGM) ⭐⭐⭐⭐

NFL picks made Thursday; odds subject to change. Our NEW NFL player prop odds tool can help you find the best odds on any market across legal sportsbooks in your area!

Deebo Samuel anytime touchdown scorer (+140) ⭐⭐⭐

Deebo Samuel is averaging 24.5 fantasy points per game in seven career outings against the Seahawks, mostly through finding the end zone consistently.

He's tallied four touchdowns in his last three regular-season matchups against Seattle. And this is a confident three-star play because of Samuel’s versatility, as two of those four touchdowns came through the air, while the other two were rushing scores. 

Samuel is tied with George Kittle for the second-best odds of any 49ers player to score a touchdown at DraftKings (+130). But given how regularly he's found paydirt against the division-rival Seahawks, the wideout should be getting more than a 41.67% implied probability to do so this week.

A $10 winning wager at Caesars’ +140 odds would net $14 in profit as part of your NFL Week 11 predictions.

Best odds: +140 via Caesars | Implied probability: 41.67%

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Best Seahawks vs. 49ers prop bets

Geno Smith Under 1.5 passing touchdowns (-130) ⭐⭐⭐⭐

Geno Smith faces a 49ers defense that's top 10 in fantasy points and passing yards allowed to quarterbacks. 

Smith threw for just one touchdown despite attempting 52 passes during a Week 6 Thursday Night Football matchup against San Francisco. Only two quarterbacks have produced over 15 fantasy points against the 49ers this season, and Smith has never thrown more than one touchdown in five games against the division rival.

This is a four-star play, as the 49ers are one of three teams Smith has scored fewer than 15 fantasy points against this year, and San Francisco has only allowed one top-15 quarterback in its last seven contests. 

Smith has logged a 2:4 touchdown-to-interception ratio in four regular-season starts against the 49ers. He should be getting much higher than a 56.52% implied probability to throw one or fewer touchdowns in this matchup.

Best odds: -130 via BetMGM | Implied probability: 56.52%

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Brock Purdy Over 254.5 passing yards (-115) ⭐⭐⭐⭐

Brock Purdy is coming off his first career game with 350-plus passing yards, two-plus touchdown passes, and zero interceptions.

His efficiency was eye-popping even without the services of Brandon Aiyuk. Purdy, who's a mid-tier contender in the NFL MVP odds, instead relied more on Jauan Jennings, who led all 49ers wide receivers in snaps, targets, catches, and receiving yards. 

Jennings and the other 49ers wide receivers should feast on a Seahawks defense that's allowed seven top-12 fantasy wide receivers in the last six games. The unit has also given up the second-most fantasy points per game to wide receivers over the last month.

This is also a four-star play because the return of Christian McCaffrey brings out the best in Purdy. Purdy is 13-4 with McCaffrey over the last two seasons while averaging 9.7 yards per attempt, posting a 33:11 touchdown-to-interception ratio, and completing 69% of his throws. Without McCaffrey, Purdy is 4-4 while averaging 8.7 yards per attempt and posting a 10:7 touchdown-to-interception ratio with a 65.0 completion percentage.

Over backers are getting great value while making this wager at BetMGM, as the total at FanDuel is eight yards higher (262.5). 

Best odds: -115 via BetMGM | Implied probability: 53.49%

Seahawks vs. 49ers game info

• When: Sunday, Nov. 17
• Kickoff: 4:05 p.m. ET 
• Where: Levi’s Stadium (Santa Clara, Calif.)
• How to watch: FOX
• Weather: 64 degrees, 30% chance of precipitation, wind 6-mph N
• Favorite: 49ers -6.5 (-110 via BetMGM)

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