Monday Night Football Odds & Predictions Week 10: Eagles vs. Packers MNF Betting Lines
NFL Week 10 will end with a bang, as the Green Bay Packers (5-2-1) host the Philadelphia Eagles (6-2) at Lambeau Field in Green Bay, Wisc., for the weekly 8:15 p.m. ET kickoff on Prime Video. The NFC North-leading Packers are a 2.5-point betting favorite by the Monday Night Football odds against the top team in the NFC East.
The Over/Under is 44.5 as we help with your NFL picks by breaking down the TNF odds and betting lines.
๐ MNF Week 10 odds: Eagles vs. Packers (-2.5)
The NFL odds for Week 10 stayed aligned with the Packers being favored, even after Green Bay was shockingly upset by the Carolina Panthers last week. Philadelphia returns from a bye and just bolstered its defense with a trade for pass rusher Jaelen Phillips.
This is a potential NFC championship preview, and our Phil Wood sides with the reigning Super Bowl champs with his early Eagles vs. Packers prediction.
Live Eagles vs. Packers odds
Our NFL odds update in real time and show the best line/odds for either side of the spread, Over/Under, and moneyline:
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๐ฎ Monday Night Football predictions Week 10
Here are our betting experts' NFL predictions for the Monday Night Football contest between the Eagles and Packers:
PHI +2.5 (-105) via Phil Wood: "The Eagles have converted 85% of red-zone attempts into touchdowns, while the Packers are allowing opponents to convert 63.64% of red-zone opportunities this year. With the Packers struggling in the red zone at home (55.56%), what happens inside the 20-yard line will give the Eagles the advantage in this game."
GB -2.5 (-110) via C Jackson Cowart: "It's certainly a tough look to lose to the Panthers at home - which we predicted could happen last week - but the Packers have been playing with their food all season. When the lights are brightest? Expect Jordan Love, Micah Parsons, and Co. to step up and frustrate these enigmatic Eagles."
๐ Monday Night Football betting results
Here are the results of the spread and Over/Under from every completed Monday Night Football game this season:
| Week | Matchup | Spread | Over/Under |
|---|---|---|---|
| 1 | Vikings vs. Bears | Vikings +1.5 | O43.5 |
| 2 | Buccaneers vs. Texas | Buccaneers +2.5 | U42.5 |
| 2 | Chargers vs. Raiders | Chargers -3.5 | U46.5 |
| 3 | Lions vs. Ravens | Lions +4.5 | O53.5 |
| 4 | Jets vs. Dolphins | Dolphins -2.5 | O43.5 |
| 4 | Bengals vs. Broncos | Broncos -7.5 | U44.5 |
| 5 | Chiefs vs. Jaguars | Jaguars +3.5 | O45.5 |
| 6 | Bills vs. Falcons | Falcons +3.5 | U49.5 |
| 7 | Buccaneers vs. Lions | Lions -6.5 | U54.5 |
| 7 | Texans vs. Seahawks | Seahawks -3.5 | O41.5 |
| 8 | Commanders vs. Chiefs | Chiefs -11.5 | U48.5 |
| 9 | Cardinals vs. Cowboys | Cardinals +3.5 | U53.5 |
๐๏ธ Monday Night Football 2025 schedule
Opening Monday Night Football NFL odds for the 2025 season regular season are via DraftKings.
| Week | Matcup | Opening spread | Opening Over/Under |
|---|---|---|---|
| 10 (Nov. 10) | Eagles vs. Packers | Eagles -1.5 | 45.5 |
| 11 (Nov. 17) | Cowboys vs. Raiders | Cowboys -1.5 | 45.5 |
| 12 (Nov. 24) | Panthers vs. 49ers | 49ers -7 | 46.5 |
| 13 (Dec. 1) | Giants vs. Patriots | Patriots -3 | 42.5 |
| 14 (Dec. 8) | Eagles vs. Chargers | Eagles -2.5 | 45.5 |
| 15 (Dec. 15) | Dolphins vs. Steelers | Steelers -2.5 | 44.5 |
| 16 (Dec. 22) | 49ers vs. Colts | 49ers -3 | 46.5 |
| 17 (Dec. 29) | Rams vs. Falcons | Rams -3 | 46.5 |
Don't miss our lists of the best NFL parlay betting sites and top NFL prop betting sites!
๐ง Monday Night Football betting tips
Get an early start
The Monday Night Football game is a big deal for betting each week. This brings lots of bets and changes in the odds, especially from those chasing their losses after a tough Sunday betting slate. Watch the lines and totals when they start. If they go the way you like, you can wait. If they move against you, think about acting sooner.
Embrace in-game betting
While you might struggle to find value in the most popular markets for any marquee prime-time NFL game, you're sure to unearth some worthwhile plays once the game starts. Live betting might not be your thing when there are a handful of games going on at the same time, but Monday Night Football is the perfect time to lay into some live action via our best live betting sites.
Be wary of winter weather
Things can get pretty frightful outside later in the NFL season โ particularly when the sun goes down. Our guide on how to bet on the NFL offers tips for how to approach betting on cold-weather games.
Check out our list of the best sportsbook promos here!
โMonday Night Football FAQs
Who is favored on Monday Night Football this week?
The Green Bay Packers are the 2.5-point betting favorite against the Philadelphia Eagles for Monday Night Football in Week 10.
How do I watch Monday Night Football?
Monday Night Football is broadcast on ESPN with some doubleheaders appearing on ABC.
Who are the announcers on Monday Night Football?
Joe Buck and Troy Aikman are the current commentators for Monday Night Football on ESPN. Laura Rutledge and Lisa Salters are the sideline reporters, and Russell Yurk is the rules analyst on the broadcast.
Who will make the most Monday Night Football appearances in 2025?
No team will make more than two appearances on Monday Night Football season.
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