Bills vs. Buccaneers Prediction, Odds & Expert Picks: NFL Preseason Week 3
The Buffalo Bills will again be without Josh Allen, and the Tampa Bay Buccaneers will rest their starters as we attempt to make the best Bills vs. Buccaneers prediction. The Bills are the 2.5-point favorites for Saturday’s 7:30 p.m. ET (ESPN Unlimited) game in Tampa.
Buffalo is 0-2 this preseason, and it was shut out 38-0 in the club's last game. Meanwhile, the Buccaneers have won both of their contests, despite Baker Mayfield not playing a snap. Who do we think holds the advantage as part of our NFL preseason Week 3 predictions?
🏈 Bills vs. Buccaneers prediction & expert picks
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✅ Against the spread pick: Buccaneers +2.5 (-105 via DraftKings) ⭐⭐⭐
✅ My best bet: Over 36.5 (-105 via Caesars) ⭐⭐
📊 Bills vs. Buccaneers odds
Live updated odds from our best live betting sites. Follow the latest NFL scores for line history and matchup info.
🪧 Bills vs. Buccaneers opening odds:
- Bills: +1.5 (-110)
- Buccaneers: -1.5 (-110)
🔮 Bills vs. Buccaneers ATS prediction
Buccaneers +2.5 ⭐⭐⭐
📊 Best odds: -105 via DraftKings ($10 to win $9.52)
🔢 Implied probability: 51.22%
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The Buccaneers aren’t playing their starters, but that's been the case at a lot of key positions this preseason, and they’re still 2-0. The offense is averaging 23 points per game, while the defense has given up just 21 total.
The Bills may boast the more experienced backups on paper, but the team has been looking lethargic all preseason. Buffalo managed just 180 yards while allowing 528 in its last game. The offense didn’t score, despite Mitchell Trubisky getting meaningful playing time.
Trubisky, Mike White, and Shane Buechele are all expected to play for Buffalo on Saturday. They each performed well in Week 1 against the New York Giants, but all three were so bad against the Chicago Bears that I can’t back the Bills as favorites, even against second-, third-, and fourth-stringers.
📖 Check out our 2025 NFL preseason betting guide for the best betting strategies and full NFL preseason schedule.
💰 Bills vs. Buccaneers best bet
⬆️ Over 36.5 ⭐⭐
📊 Best odds: -105 via Caesars ($10 to win $9.52)
🔢 Implied probability: 51.22%
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The Bills have allowed 34-plus points in each of their preseason games. If that continues, then this Over will easily hit. However, the Buccaneers scored just 17 in their last game, and the total in both of the team's preseason outings has been 36 or fewer.
With both teams resting starters, whether the Over or Under will hit is a tossup. However, I’ll back the Over because of what the Bills’ quarterbacks are playing for this week.
Each one is competing to back up Allen, and it’s hard to imagine the Bills hold confidence in any of them after last week. All three players showed potential against the Giants, and I expect them to enjoy more success against the Buccaneers’ defensive backups on Saturday.
🤑 Bills vs. Buccaneers betting insights
Let's dive into the numbers and see what the public is betting prior to kickoff, courtesy of BetMGM.
| Teams | Opening Spread | Current Spread | % Bets | % Handle |
|---|---|---|---|---|
| Buffalo Bills | +1.5 | -2.5 | 62% | 67% |
| Tampa Bay Buccaneers | -1.5 | +2.5 | 38% | 33% |
62% of bets are flying in on the Bills, but our best bets are with the Bucs. Tampa Bay isn't playing their starters, but that's been the case at a lot of key positions this preseason, and they're still 2-0. The offense is averaging 23 points per game, while the defense has given up just 21 total.
| Teams | Opening Total | Current Odds | % Bets | % Handle |
|---|---|---|---|---|
| Over | 37.5 | 36.5 | 76% | 87% |
| Under | 37.5 | 36.5 | 24% | 13% |
Looks like the public is siding with us on this one, with 87% of the handle on the Over. The Bills have allowed 34-plus points in each of their preseason games. If that continues, then this Over will easily hit. However, the Buccaneers scored just 17 in their last game, and the total in both of the team's preseason outings has been 36 or fewer.
🚑 Bills vs. Buccaneers injuries
❓ NFL betting FAQs
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In NFL betting, the spread is the number of points a team is favored to win or lose by. It levels the playing field for bettors by giving an advantage or disadvantage in points. Bettors win if their pick covers the spread.
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