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49ers vs. Eagles Predictions, Picks & Odds Week 13: Will Philadelphia’s First-Half Struggles Continue?

Mike Spector

Last Updated: December 3, 2023 2:21 PM EST • 4 min 27 sec read.

The NFC's top-two teams meet in a mammoth clash headlining the NFL's Week 13 slate as the Philadelphia Eagles host the San Francisco 49ers, and we offer our best 49ers vs. Eagles prediction based on the NFL odds at our best sportsbooks for this 2023 NFC Championship rematch.

Entering this week, the San Francisco 49ers stand as one of the three 8-3 teams in the NFC and among five in the NFL on a three-game winning streak or more. On Thanksgiving, the 49ers secured an 18-point victory over the Seattle Seahawks, marking their 10th consecutive divisional win, the most extended active streak in the league.

Meanwhile, the Philadelphia Eagles achieved a rare feat, becoming the first team since the 1991 Buffalo Bills to lose a Super Bowl and start the next season 9-1 or better. They currently hold a 10-1 record, largely attributed to Jalen Hurts' exceptional performance, achieving his first career five-touchdown game.

To accompany our 49ers vs. Eagles NFL player props, here is our best 49ers vs. Eagles prediction and our NFL picks (odds via our best NFL betting sites; pick confidence based on a 1-to-5-star scale).

For more action on this game, don't miss our Jalen Hurts NFL player props, Brock Purdy props, Christian McCaffrey props, and our A.J. Brown NFL player props.

49ers vs. Eagles prediction

49ers first-half moneyline (-125 via Caesars, bet365) ⭐⭐⭐

This can potentially kick off as a historical game from a point-spread perspective. Per BetMGM's John Ewing, only three teams since 2004 with odds of 10-1 or better have been home underdogs. However, in two of those instances, the underdog had backup quarterbacks starting since the games were played in Week 17. 

Thus, our best sports betting apps are tipping their hand that they feel San Francisco is the better team and will expose Philadelphia amid a torrid start. But instead of backing the 49ers for the full game, we are targeting the first-half moneyline based on how the Eagles have started games recently.

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Philadelphia's five-game winning streak is tied with the Denver Broncos for the longest active streak. Still, it's largely due to out-scoring opponents 79-30 in the second half and overtime of the last four games, as it has trailed at the half in four straight (and is 5-0 in games it has trailed at halftime this season). 

In the first 30 minutes of all games this season, Hurts ranks 15th in QBR, is tied for 17th in passing touchdowns, and is 19th in yards per attempt. However, in the second halves of all games (and overtime periods), Hurts improves to third in QBR, tied for second in passing touchdowns, and fourth in yards per attempt.

While the Eagles won without right tackle Lane Johnson last week, they are just 14-22 when he does not suit up, and his injury will be something to monitor this week. Conversely, San Francisco is the healthiest it has been all season and has the NFL's second-best point differential (+140). Its three-game hiccup from Weeks 6-8 was heavily tied to injuries to Deebo Samuel and Trent Williams, but with them back in the fold, Brock Purdy has completed 75.3% of his passes with a 7-1 TD-INT ratio over the last three games. 

This is a three-star play, as the 49ers defense allows a league-best 9.5% of opponents' possessions to end in a touchdown in road games, per Sharp Football Analysis. We would make this a more confident four-star play if the weather forecast improved, as Purdy's worst game this season in terms of completion percentage, yards per attempt, and QBR was on the road in a soaking rain at the Cleveland Browns.

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49ers vs. Eagles best odds

Caesars, bet365 (-125)

DraftKingsFanDuelBetMGMCaesarsbet365
-130-128N/A-125-125

49ers first-half moneyline backers will find the best value at either Caesars or bet365, with their odds climbing as high as -130 at DraftKings. Caesars and DraftKings offer the same -0.5 point spread while FanDuel is slightly higher at -1.5, but we prefer the added insurance at a slightly higher price with the moneyline odds, as our bet would be voided and returned if the 49ers and Eagles are tied at halftime. 

We are also not looking to fade Philadelphia for the full-game moneyline, as it is 11-0 straight up in its last 11 games at Lincoln Financial Field against teams with a winning record.

49ers vs. Eagles odds

49ers vs. Eagles odds analysis

There is a wide range regarding the point spread among the best sports betting apps for this matchup. BetMGM is the only shop offering a line as low as San Francisco -1.5 (though it charges -130 in juice to back the favorite), while DraftKings is the highest on the 49ers at -3 (-102). All other competitors are slightly under a field goal at -2.5, though FanDuel did hit -3 on Tuesday before lowering back down to -2.5. The Eagles are a popular underdog, attracting 80% of the early point spread wagers.

Caesars is the only sportsbook offering a total of 45.5, while the rest of the best sports betting sites are a full point higher at 46.5. DraftKings opened at 46 on Sunday night but has had its total bounce between 46.5 and 47 multiple times early in the week. There is dead-even, two-way action on the total across all of our best sportsbooks, while the Eagles have the longest active Over streak (four games) in the league.

49ers vs. Eagles game info

  • When: Sunday, Dec. 3 at 4:25 p.m. ET
  • Where: Lincoln Financial Field, Philadelphia, PA
  • How to watch: FOX
  • Weather: 54 degrees, 52% chance of precipitation, wind 9 mph NNE

49ers-Eagles prediction made 11/29/2023 at 4:01 p.m. ET

NFL betting odds pages

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NFL MVP OddsNFL Comeback Player of the Year OddsNFL Best Record Odds
NFL Offensive Player of the Year OddsNFL Most Regular Season Passing Yards OddsNFL Worst Record Odds
NFL Defensive Player of the Year OddsNFL Most Regular Season Rushing Yards OddsNFL Win Totals Odds
NFL Coach of the Year OddsNFL Most Regular Season Receiving Yards OddsNFL Draft Odds
NFL Offensive Rookie of the Year Odds

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Written By:
Mike Spector
Mike started in the sports writing industry in July 2019, and gained a lot of followers in his first year after finishing with the No. 2 overall record in an annual NFL betting competition, which made picks against the spread, and from an Over/Under and moneyline perspective. Mike is an avid fan of the NFL, MLB, tennis, and all college sports. In his opinion, March Madness is the best sporting event there is, and he's especially euphoric starting with conference tournament time in college basketball. Mike's a big advocate of "fading the public" and making plays that are contrarian, constantly citing that "there are reasons why they have those big shiny buildings in Las Vegas." When making wagers, Mike always scours the best odds at all of the major sports betting sites, where he mostly sifts through DraftKings, FanDuel, BetMGM, and bet365. He's tried several others and is of the firm belief that bettors should not just stick to one sportsbook, as there is always likely better value to be had with the same wager. In addition, while Mike received his undergraduate degree from Villanova University, he has no issue betting against the Wildcats when it comes to college basketball wagering, and suggests other bettors should always put their “head” before their “hearts.”