NFL AI Predictions: Week 10 ATS Picks & Score Projections for Every Matchup
Our NFL AI predictions for Week 10 feature projected scores and against-the-spread picks for all 14 games on the schedule, including several important divisional matchups.
Week 10 begins Thursday with the Washington Commanders visiting the New York Giants. Sunday's slate features the New England Patriots and Detroit Lions squaring off in Munich, Germany, along with the Minnesota Vikings at Green Bay Packers and San Francisco 49ers at Dallas Cowboys.
The AI-assisted projections consider recent performance, advanced metrics, injuries, roster strength, matchup advantages, home-field edge, and current market movement. ATS selections use Kalshi's NFL spread markets as of Thursday, November 12.
Check out the complete 2026 NFL schedule and follow all of SBR's NFL picks throughout the season.
NFL AI predictions for Week 10
| Date | Kickoff (ET) | Prediction | ATS pick |
|---|---|---|---|
| Thu., Nov. 12 | 8:15 p.m. | Giants 24, Commanders 16 | Giants -2.5 |
| Sun., Nov. 15 | 9:30 a.m. | Lions 31, Patriots 20 | Lions -2.5 |
| Sun., Nov. 15 | 1 p.m. | Chiefs 30, Falcons 17 | Chiefs -3.5 |
| Sun., Nov. 15 | 1 p.m. | Browns 23, Texans 20 | Browns +5.5 |
| Sun., Nov. 15 | 1 p.m. | Packers 27, Vikings 13 | Packers -3.5 |
| Sun., Nov. 15 | 1 p.m. | Colts 27, Dolphins 17 | Colts -4.5 |
| Sun., Nov. 15 | 1 p.m. | Saints 27, Panthers 20 | Saints -2.5 |
| Sun., Nov. 15 | 1 p.m. | Bills 31, Jets 17 | Bills -7.5 |
| Sun., Nov. 15 | 1 p.m. | Jaguars 34, Titans 13 | Jaguars -10.5 |
| Sun., Nov. 15 | 4:05 p.m. | Rams 30, Cardinals 17 | Rams -9.5 |
| Sun., Nov. 15 | 4:05 p.m. | Seahawks 27, Raiders 16 | Seahawks -6.5 |
| Sun., Nov. 15 | 4:25 p.m. | 49ers 31, Cowboys 27 | Cowboys +4.5 |
| Sun., Nov. 15 | 8:20 p.m. | Steelers 24, Bengals 20 | Steelers +3.5 |
| Mon., Nov. 16 | 8:15 p.m. | Ravens 23, Chargers 16 | Ravens -4.5 |
Commanders vs. Giants AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Commanders | 3 | 7 | 0 | 6 | 16 |
| Giants | 7 | 10 | 0 | 7 | 24 |
New York enters Week 10 with momentum following a 19-11 victory over Philadelphia, while Washington struggled offensively in a 20-13 defeat to the Rams. The Giants have been more consistent defensively and should benefit from playing at home. Expect New York to control possession and cover the short spread.
ATS pick: Giants -2.5
Patriots vs. Lions AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Patriots | 3 | 10 | 0 | 7 | 20 |
| Lions | 7 | 10 | 7 | 7 | 31 |
New England suffered a disappointing 45-27 defeat to Green Bay last weekend, exposing significant defensive vulnerabilities. Detroit, meanwhile, continues to build momentum following a 19-9 victory over Miami. Playing in Munich adds another variable, but the Lions have the offensive balance to establish control and win comfortably.
ATS pick: Lions -2.5
Chiefs vs. Falcons AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Chiefs | 7 | 13 | 3 | 7 | 30 |
| Falcons | 0 | 10 | 0 | 7 | 17 |
Kansas City bounced back impressively from consecutive defeats, dominating the Jets 35-12 last weekend. Atlanta has lost two straight games and surrendered 34 points to Cincinnati in Week 9. The Chiefs should have advantages on both sides of the ball and can create enough offensive opportunities to cover on the road.
ATS pick: Chiefs -3.5
Texans vs. Browns AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Texans | 7 | 3 | 3 | 7 | 20 |
| Browns | 3 | 10 | 3 | 7 | 23 |
Houston was outstanding in its 44-22 victory over the Chargers last weekend, but Cleveland presents a tougher defensive assignment. The Browns narrowly lost to New Orleans and return home looking to improve their AFC playoff positioning. Cleveland has enough defensive talent to disrupt the Texans and potentially secure an upset.
ATS pick: Browns +5.5
Vikings vs. Packers AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Vikings | 0 | 3 | 3 | 7 | 13 |
| Packers | 7 | 10 | 3 | 7 | 27 |
Green Bay enters after hanging 45 points on New England, while Minnesota struggled offensively in its 23-6 loss to Buffalo. The Packers should enjoy an advantage at home, especially with uncertainty surrounding Minnesota's injured players. Green Bay's passing attack could create separation before the fourth quarter.
ATS pick: Packers -3.5
Dolphins vs. Colts AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Dolphins | 3 | 7 | 0 | 7 | 17 |
| Colts | 7 | 10 | 3 | 7 | 27 |
Indianapolis has endured a difficult stretch but was competitive in a narrow 27-23 loss to Dallas last weekend. Miami continues to struggle offensively and managed just nine points against Detroit in Week 9. The Colts should have enough offensive firepower to take advantage of the Dolphins' inconsistencies and secure a home victory.
ATS pick: Colts -4.5
Panthers vs. Saints AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Panthers | 7 | 3 | 3 | 7 | 20 |
| Saints | 3 | 14 | 3 | 7 | 27 |
New Orleans narrowly escaped Cleveland with a 23-22 victory, while Carolina suffered its third straight defeat against Denver. Neither team has been particularly consistent, but the Saints should benefit from home-field advantage against a familiar divisional opponent. New Orleans has enough offensive upside to produce a comfortable victory.
ATS pick: Saints -2.5
Bills vs. Jets AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Bills | 7 | 10 | 7 | 7 | 31 |
| Jets | 3 | 7 | 0 | 7 | 17 |
Buffalo's defense was dominant Monday, holding Minnesota to six points in a 23-6 victory. New York managed only 12 points against Kansas City last weekend and faces another difficult opponent. The Bills should control field position and generate enough offense to build a multi-score lead.
ATS pick: Bills -7.5
Jaguars vs. Titans AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Jaguars | 10 | 14 | 3 | 7 | 34 |
| Titans | 3 | 3 | 0 | 7 | 13 |
Jacksonville continues to impress and enters this AFC South matchup following a dominant 33-10 victory over Baltimore. Tennessee returns from its bye with just one victory this season and faces a difficult defensive assignment. The Jaguars should control the line of scrimmage and generate enough explosive plays to win by multiple touchdowns.
ATS pick: Jaguars -10.5
Rams vs. Cardinals AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Rams | 7 | 10 | 3 | 10 | 30 |
| Cardinals | 0 | 10 | 0 | 7 | 17 |
The Rams have won three straight games and continue to demonstrate impressive defensive consistency, most recently holding Washington to 13 points. Arizona was completely overwhelmed by Seattle in a 17-3 defeat. Los Angeles should have enough offensive balance to control this divisional matchup and cover on the road.
ATS pick: Rams -9.5
Seahawks vs. Raiders AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Seahawks | 7 | 7 | 10 | 3 | 27 |
| Raiders | 3 | 3 | 3 | 7 | 16 |
Seattle responded from its disappointing loss to Chicago with another impressive defensive showing, holding Arizona to three points. Las Vegas struggled badly against San Francisco and now faces another challenging NFC West opponent. The Seahawks should have the defensive advantage and enough offensive consistency to win comfortably in Las Vegas.
ATS pick: Seahawks -6.5
49ers vs. Cowboys AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| 49ers | 7 | 10 | 7 | 7 | 31 |
| Cowboys | 7 | 10 | 3 | 7 | 27 |
San Francisco continues to look like one of the NFC's strongest teams following a convincing 38-17 victory over Las Vegas. Dallas also enters with momentum after defeating Indianapolis. The 49ers should have the advantage overall, but the Cowboys possess enough offensive firepower to keep this competitive at home.
ATS pick: Cowboys +4.5
Steelers vs. Bengals AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Steelers | 3 | 7 | 7 | 7 | 24 |
| Bengals | 7 | 3 | 7 | 3 | 20 |
Both teams enter this crucial AFC North matchup with identical 6-2 records. Pittsburgh returns from its bye with additional preparation time, while Cincinnati has built momentum behind another strong offensive performance against Atlanta. The Bengals have the home-field advantage, but Pittsburgh's defense could make the difference in a competitive divisional showdown.
ATS pick: Steelers +3.5
Chargers vs. Ravens AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Chargers | 3 | 7 | 0 | 6 | 16 |
| Ravens | 3 | 10 | 3 | 7 | 23 |
Baltimore has lost four straight games and continues to deal with major quarterback concerns following Lamar Jackson's thumb injury. However, the Chargers remain winless and were overwhelmed by Houston in a 44-22 defeat. Despite their recent struggles, the Ravens should have enough defensive talent and home-field advantage to earn a much-needed victory.
ATS pick: Ravens -4.5
More NFL picks for Week 10
For more analysis ahead of Week 10, check out SBR's NFL picks, the latest NFL odds, NFL MVP odds, and the complete 2026 NFL schedule.
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