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Christian McCaffrey of the San Francisco 49ers carries the ball ahead of our Week 13 NFL Sunday Night Football predictions for 49ers vs. Eagles
Christian McCaffrey #23 of the San Francisco 49ers runs with the ball during the third quarter against the Seattle Seahawks at Lumen Field on November 23, 2023 in Seattle, Washington. Photo by Steph Chambers/Getty Images/AFP

The Philadelphia Eagles host the San Francisco 49ers in the best game of the NFL's Week 13 slate, and we make our best Christian McCaffrey NFL player prop predictions based on the best NFL odds at our top NFL prop betting sites.

Christian McCaffrey, the running back for the San Francisco 49ers, has accumulated 939 rushing yards, surpassing other players by 154 yards this season. He's also tied for second in rushing touchdowns with a total of 11 and has caught 48 passes for 389 yards, contributing five touchdowns.

In the upcoming game against the Philadelphia Eagles, McCaffrey is set to challenge the third-ranked run defense in the NFL. Despite their ranking, the Eagles have recently allowed an average of 138.0 rushing yards per game over the last three matchups.

The question lingers: How will McCaffrey perform against the Eagles' defense on Sunday?

To round out our 49ers vs. Eagles predictions and 49ers-Eagles NFL player props, here are our best Christian McCaffrey NFL player prop predictions (odds via our best NFL betting sites; pick confidence based on a 1-to-5-star scale).

For more on Sunday's NFC clash, see our Jalen Hurts NFL player props, Brock Purdy props, and A.J. Brown player props.

Christian McCaffrey NFL player prop predictions for Week 13

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Christian McCaffrey player props

Christian McCaffrey Under 72.5 rushing yards (-110 via bet365) ⭐⭐⭐

The Eagles allowed the Buffalo Bills to compile 173 rushing yards against them last week. However, the running backs were barely responsible for half of that yardage, as Josh Allen led the team with 81 yards. The Eagles haven’t allowed a running back to rush for 60 yards this season.

McCaffrey leads the league in rushing yards, but he’s had his fair share of lackluster rushing performances this season. He’s rushed for over 100 yards four times, the same amount of games he’s rushed for fewer than 60 yards. With the clear advantage the 49ers have in the passing attack, McCaffrey won’t get enough carries to hit this over against a great run defense.

FanDuel has this prop listed at 73.5, but they’re asking -114 for the under. Because of the price that bet365 is offering, it’s not worth getting the extra yard for FanDuel’s offer.

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Christian McCaffrey Over 4.5 receptions (-105 via BetMGM) ⭐⭐⭐

Even though McCaffrey may struggle to run on Sunday, the 49ers aren’t going to cut him from their game plan entirely. He’s caught at least five passes in four consecutive games and averaging 4.4 receptions per contest.

The Eagles have the fourth-worst pass defense in the league so Brock Purdy will throw plenty in this game. While he should succeed going down the field, McCaffrey will always be there as a safety net or on designed screens. McCaffrey going over his reception total is more enticing than his yardage, just in case the Eagles’ defensive front blows up some screens.

Every one of our major best sportsbooks has this prop set at 4.5. Only DraftKings and BetMGM ask -105 for the over, while every other sportsbook asks at least -110. This number will unlikely go down, even as the under continues to be favored at most NFL prop betting sites.

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Christian McCaffrey first touchdown scorer (+450 via FanDuel) ⭐⭐

McCaffrey has scored a touchdown in all but one game this season. Because of that, his price to score an anytime touchdown is greater than -200 at every one of our major NFL prop betting sites. While that prop is worth parlaying with some other props, it’s hard to justify taking it on its own at such a price.

However, McCaffrey’s first touchdown scorer price is very good across each of our best sportsbooks. Though the Eagles scored first last week, they’ve been outscored 17-7 in the first half of each of their last two games. Meanwhile, the 49ers are averaging over 15 points per first half, the fourth-most in the NFL. If the 49ers jump out to an early lead in this game, there’s a good chance it’s because of McCaffrey.

The price ranges from +350 to +450 across our best sports betting apps. Check each before placing this wager, as this price will likely change as the week progresses. Right now, the price at FanDuel is the best by a significant margin.

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Christian McCaffrey player prop picks made 12/2/2023 at 9:01 a.m. ET.

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