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Jalen Hurts of the Philadelphia Eagles calls a play as part of our Week 13 NFL predictions for 49ers vs. Eagles
Jalen Hurts of the Philadelphia Eagles calls a play during the fourth quarter against the Buffalo Bills at Lincoln Financial Field on November 26, 2023 in Philadelphia, Pennsylvania. Photo by Tim Nwachukwu/Getty Images/AFP

The Philadelphia Eagles host the San Francisco 49ers as we make our best 49ers vs. Eagles NFL player props for Week 13 based on the best NFL odds at our best NFL prop betting sites.

During a three-game winning streak, the San Francisco 49ers have dominated, averaging a 20.6-point victory margin against their opponents. Christian McCaffrey, the star running back for the 49ers, leads the NFL in rushing yards, while their defense boasts the fewest points allowed per game.

The Philadelphia Eagles clinched another thrilling win last week, boosting their record to 10-1 for the season. Heading into this week, quarterback Jalen Hurts is tied for the second-most rushing touchdowns in the league, sharing this achievement with McCaffrey.

Few matchups this season have a had a greater impact on the Super Bowl odds than what's expected to come from this showdown.

To complement our 49ers vs. Eagles prediction, here are our best 49ers vs. Eagles NFL player props for Week 13 (odds via our best NFL betting sites; pick confidence based on a 1-to-5-star scale).

Don't miss our Jalen Hurts NFL player props, Brock Purdy props, Christian McCaffrey props, and A.J. Brown player props for more on Sunday's marquee showdown.

49ers vs. Eagles NFL player props: Week 13

Brock Purdy Over 254.5 passing yards (-110 via bet365) ⭐⭐⭐⭐

It’s hard to believe how bad the Eagles’ pass defense has been this season, considering they’re 10-1. They’re allowing 255.7 passing yards per game – fourth-worst in the NFL – and they’re allowing 2.1 touchdown passes per game – second-worst in the league.

Purdy threw for just 209 yards last week against the Seahawks, but he had thrown for at least 272 yards in his four games before that performance. He’s beaten up on bad secondaries throughout the season and has his full arsenal of weapons available for Sunday. This prop is playable up to 275.

Every major sportsbook has the total listed at 254.5. The prices range from -110 to -129, with bet365 offering the best price right now.

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Jalen Hurts anytime touchdown scorer (+110 via bet365) ⭐⭐⭐⭐

It doesn’t matter who Hurts is playing; if you can get him to score a touchdown for -110 or better, then you have to take it. Hurts has scored 11 touchdowns this year and at least one in eight of his 11 games. He’s scored at least one in six of his last seven games.

The Brotherly Shove is an unstoppable play, and with how well the Eagles’ offense moves the ball, there is no reason to think that Hurts won’t have opportunities in the red zone like he has had in almost every game this season. The Eagles don’t get cute around the goal line like other teams do. They let their quarterback push the pile.

The price for this bet ranges from -125 to +110. We wouldn’t take this at -125 just because Hurts is playing the 49ers. The good news is there are three of our best sports betting apps with -105 or better for this prop.

Deebo Samuel Over 49.5 receiving yards (-110 via bet365) ⭐⭐⭐

Last week, Samuel caught seven passes for 79 yards. The performance marked his second in a row with more than 60 receiving yards. This season, he’s racked up at least 50 receiving yards in six of his nine games. 

Though McCaffrey leads the league in rushing, he may have difficulty getting going against a very good Eagles run defense. Because of that, Purdy will throw most of this game. We believe that Purdy will have success, which means his receivers are going to as well. With Brandon Aiyuk’s total listed in the 60s, Samuel is the best receiving play of the game.

Four of the five major sportsbooks have this prop listed at 49.5. While some of our best sportsbooks are asking -120 or higher for this prop, bet365 has a price of -110. FanDuel has the prop set at 51.5, but they’re asking -114 for the over.

49ers vs. Eagles player props made Saturday at 8:23 a.m. ET

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