NFL Picks Against the Spread Week 10: ATS Predictions for Every Game

I'm backing three road favorites as my feature picks for the NFL ATS picks Week 10. Road favorites boast a 32-22-2 ATS record through nine weeks (58.9%) as I hone in on three NFC West teams with Super Bowl aspirations. 

I've also provided an ATS pick for each game on the Week 10 slate, backing five underdogs and nine favorites. Favorites are sporting a 66-65-5 record entering Week 10 action. 

NFL picks against the spread: Week 10 ATS predictions

See all of our experts' NFL picks for Week 10 based on the latest NFL odds; pick confidence based on a 1-to-5-star scale.

Picks submitted: Nov. 10 @ 8 a.m. ET. Odds subject to change. 

Best ATS pick for Week 10 

Want more NFL betting advice? Check out all of our NFL analysis and expert predictions for every game in Week 10.

49ers (-3.5) vs. Cowboys ⭐⭐⭐⭐

There's no way I'm trusting a Dallas Cowboys team with the fourth-worst defensive DVOA and second-worst defensive EPA per play to keep things close against the irrepressible San Francisco 49ers.

Despite winning only one of two true road games, the 49ers are a juggernaut ranking among the top 10 in defensive DVOA and EPA per play while boasting the second-best offense via DVOA, which scores the third-most points per game.

The game being at AT&T holds no weight, as the Cowboys have lost three of four there, including woeful outings against mediocre teams like the Tampa Bay Buccaneers and Washington Commanders. 

More Week 10 picks

Seahawks (-3.5) vs. Raiders ⭐⭐⭐⭐

I'm going with another road favorite as the Las Vegas Raiders' promising start is a distant memory. They have lost five of the last six, and Kirk Cousins is hanging on to his job by a thread.

Regardless of whether he starts or the Raiders turn to Fernando Mendoza, which is a matter of when, not if, the Raiders' defense hasn't been good enough to give them a chance. That unit has allowed at least 30 points in six straight, with the average sitting at 35.7.

Drew Lock will start under center for the Seattle Seahawks, but I don't see that hurting their chances of covering. The backup QB has been excellent this season, winning all three starts with five TD passes and no interceptions. 

Rams (-8.5) vs. Cardinals ⭐⭐⭐⭐

The Rams lost to the Arizona Cardinals at SoFi Stadium in Week 6, so the Week 10 matchup feels like a perfect bounce-back/revenge game for Sean McVay's team.

The Rams enter on a three-game win streak, and Myles Garrett had three sacks in his return to the lineup against the Washington Commanders in Week 9. 

The Rams defense hasn't allowed more than 21 points in four straight, and Carson Beck is set to make his first start after Gardner Minshew went down with an injury in Week 9. Rookies have fared historically poorly in their first start, and I don't love Beck's chances of success against a healthy Garrett, Aaron Donald, and Co.