NFL Preseason Week 1 Predictions 2025: Odds & Best Bets for All 16 Games This Week

We're breaking down the latest odds with our expert picks for every NFL preseason game this week.

Last Updated: August 4, 2025 3:15 PM EDT • 3 minute read

NFL Preseason Week 1 Predictions 2025: Odds & Expert Picks for All 16 Games — LA Chargers tight end Will Dissly (89) celebrates a touchdown with quarterback Trey Lance (5). Photo by Junfu Han / USA TODAY NETWORK via Imagn Images.

With the Hall of Fame Game behind us, the first official week of the NFL preseason kicks off Thursday with 16 games through Sunday afternoon.

We've compiled the latest NFL predictions and odds for Week 1 of the preseason, including our expert picks for all 16 games (which we'll add throughout the week) and live betting lines from the best sports betting sites for every game this week.

🏈 NFL predictions & picks: Week 1 preseason best bets

🔎 Our NFL player prop odds tool can help you find the best NFL odds to make your NFL picks across legal sportsbooks in your region.

Colts vs. Ravens prediction (coming soon)
Raiders vs. Seahawks (coming soon)
Browns vs. Panthers (coming soon)
Commanders vs. Patriots (coming soon)
Giants vs. Bills (coming soon)
Jets vs. Packers (coming soon)
Texans vs. Vikings (coming soon)
Dolphins vs. Bears (coming soon)
Saints vs. Chargers (coming soon)

📖 Check out our 2025 NFL preseason betting guide for our best betting strategies and full NFL preseason schedule.

💰 NFL preseason odds: Week 1

Here are the latest odds for every game via the best NFL betting sites, which update live in real time. Follow the latest NFL scores for line history and matchup info.

📊 Colts vs. Ravens odds

📊 Bengals vs. Eagles odds

📊 Raiders vs. Seahawks odds

📊 Lions vs. Falcons odds

📊 Browns vs. Panthers odds

📊 Commanders vs. Patriots odds

📊 Giants vs. Bills odds

📊 Texans vs. Vikings odds

📊 Steelers vs. Jaguars odds

📊 Cowboys vs. Rams odds

📊 Titans vs. Buccaneers odds

📊 Chiefs vs. Cardinals odds

📊 Jets vs. Packers odds

📊 Broncos vs. 49ers odds

📊 Dolphins vs. Bears odds

📊 Saints vs. Chargers odds

🔢 NFL betting odds pages

Super Bowl Odds	NFL MVP Odds	NFL Offensive Player of the Year Odds
NFL Defensive Player of the Year Odds	NFL Offensive Rookie of the Year Odds	NFL Defensive Rookie of the Year Odds
NFL Coach of the Year Odds	NFL Comeback Player of the Year Odds	NFL Win Totals Odds
NFL Playoff Odds	NFL Draft Odds

❓ NFL betting FAQs

What does the spread mean in betting NFL?

In NFL betting, the spread is the number of points a team is favored to win or lose by. It levels the playing field for bettors by giving an advantage or disadvantage in points. Bettors win if their pick covers the spread.

Where can I find top NFL betting odds?

Make sure you look at our top NFL betting sites to find the best odds for NFL Sunday. These sportsbooks include Caesars, BetMGM, bet365, FanDuel, and DraftKings.

💵 Best NFL betting sites

Want to bet on NFL preseason Week 1? Check out our best NFL betting sites and the best sportsbook promos for the 2025 NFL season:

FanDuel Promo Code | Read our FanDuel Review
DraftKings Promo Code | Read our DraftKings Review
Hard Rock Bet Promo Code | Read our Hard Rock Bet Review

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* Bonuses not applicable in Ontario.

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Each betting site featured on SBR has been meticulously researched and selected by our team of experts. If you sign up through our links, we may get a commission.

Written by:
C Jackson Cowart

C Jackson Cowart is a publishing editor and lead writer for Sportsbook Review. An award-winning writer, reporter, and editor with a decade of sports media experience, "C-Jax" has worked with ESPN, Forbes, theScore, and various daily newspapers before joining the Sportsbook Review team. He's a proud graduate of the University of North Carolina, where he served as a beat writer for the Tar Heels' championship run through the NCAA men's basketball tournament in 2017. Jackson has spent the last five years covering sports betting as a predictive analyst, features writer, and industry reporter. Since joining the team in 2023, he's played a key role in Sportsbook Review's coverage of the Super Bowl, March Madness, and NBA playoffs while serving as the lead writer for the growing WNBA and NASCAR betting scenes. Though he's cashed some big bets over the years -- including Lamar Jackson to win MVP (twice) -- he's still haunted by enough second-place bet slips to wallpaper his home office. While Jackson is a committed "process over results" bettor with a keen eye for advanced stats and subtle bias in futures markets, he also embraces sports betting as a vehicle for entertainment and personal investment. He's written about everything from hot dogs to groundhogs and still hasn't forgiven his "inside source" for a sabotaged bet on the Gatorade color in Super Bowl LV.

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