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Christian McCaffrey of the San Francisco 49ers reacts to a touchdown during the first quarter against the Los Angeles Rams, and we offer our top odds and predictions for NFL Offensive Player of the Year based on the best NFL odds.
Christian McCaffrey of the San Francisco 49ers reacts to a touchdown during the first quarter against the Los Angeles Rams. Photo by Sean M. Haffey/Getty Images via AFP.

Our New York Giants vs. San Francisco 49ers player props for Thursday Night Football are based on the best TNF odds as we kick off the NFL's Week 3 in search of three winning selections.

Our Thursday Night Football best bets help set the stage as the 2-0 San Francisco 49ers and the 1-1 New York Giants. Both teams won their Week 2 game, though in a very different fashion. The NFL Week 3 odds view these teams extremely differently.

San Francisco beat the Pittsburgh Steelers and the Los Angeles Rams comfortably to open its season. Meanwhile, New York needed a miracle comeback against the Arizona Cardinals to avoid falling to 0-2.

The Giants will have their work cut out for them slowing down a red-hot San Francisco offense. They will also have to keep a tenacious 49ers defense away from their quarterback, without one of their best players on offence to help take pressure off of him.

To complement your Giants vs. 49ers predictions, here are our best Giants vs. 49ers player props for Thursday Night Football to help you start on the right foot with your NFL predictions for Week 3 (NFL odds via our best NFL betting sites; pick confidence based on a 1-to-5-star scale).

Giants vs. 49ers player props: Thursday Night Football

Christian McCaffrey 100+ rushing yards + 1+ rushing touchdown (+285 via DraftKings) ⭐⭐⭐⭐⭐

In 11 games last season with the 49ers, Christian McCaffrey scored a rushing touchdown in six of them. At one point, he had a span of four straight games in which he crossed the goal line on a carry. He also added a rushing touchdown in two of his three postseason appearances with San Francisco. So far this season, CMC has put the ball in the endzone on the ground in each of his first two games.

The Giants have allowed five rushing touchdowns on the season. New York surrendered two touchdowns to Cowboys running back Tony Pollard and one more to kick returner KaVontae Turpin. Last week, Arizona Cardinals running back James Conner, as well as quarterback Joshua Dobbs, ran for six against the Giants' defense.

Our Phil Wood also has a positive look on the 49ers' star with his Christian McCaffrey NFL player props.

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Darius Slayton & Isaiah Hodgins each Over 39.5 receiving yards (+425 via Caesars) ⭐⭐⭐⭐

In his season debut, Daniel Jones threw for just 104 yards. No pass catcher had more than 36 receiving yards in that game. Last week, the Giants offense rebounded to the tune of 321 yards through the air for Jones. Four New York pass-catchers exceeded this prop total, including Darius Slayton and Isaiah Hodgins.

Last season, Hodgins crossed this threshold in five of 10 games including three of his last five. The young wideout accounted for 40 receiving yards last week against the Arizona Cardinals. As for Slayton, he exceeded this mark in eight of 10 games in 2022. Against Arizona, he accumulated 62 yards.

San Francisco has allowed at least two receivers to gain more than 40 yards in both of their games this season. Last week, three players cashed this prop against the 49ers' secondary.   

Additionally, Saquon Barkley has been ruled out, meaning Jones will have to more heavily rely on his wide receivers, as well as his star tight end.

Darren Waller -1.5 targets vs. George Kittle (+115 via DraftKings) ⭐⭐⭐⭐

The Giants signed Darren Waller to be a major part of their passing game. He has been the most targeted pass-catcher for New York in both games this season, supporting that idea. His quarterback looked his way five times in Week 1. He followed that with eight targets in Week 2. 

As talented as George Kittle is, he is surrounded by equally talented 49ers pass-catchers. In Week 1, he was third on the target list, garnering six looks from Brock Purdy against the Steelers. Against the Rams in Week 2, he was called on only three times to catch the ball. 

Giants vs. 49ers player props for Thursday Night Football made Tuesday at 10 p.m. ET

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