Chiefs vs. 49ers Player Prop Bet Odds & Touchdown Picks: Kelce Continues His Dominance
The San Francisco 49ers host the Kansas City Chiefs as they look to hand the defending Super Bowl champions their first loss of the season. The teams are again the leading contenders in the 2025 Super Bowl odds, and Chiefs quarterback Patrick Mahomes leads the NFL MVP odds.
With so many injuries to both of these offenses, making the best Chiefs vs. 49ers player prop bet picks forces you to determine what’s temporary and what’s permanent. For example, Travis Kelce has become the leading receiver for the Chiefs since Rashee Rice’s injury. Based on his history, that type of production is likely here to stay.
But will George Kittle really continue to score a touchdown per week, as he's done so far this season? And what should we make of Kareem Hunt’s hot start with the Chiefs?
Chiefs vs. 49ers NFL player prop bets: Sunday
Odds as of Friday and subject to change.
- George Kittle touchdown pick: Anytime touchdown scorer (+165 via FanDuel) ⭐⭐⭐
- Travis Kelce Over 6.5 receptions (+135 via bet365) ⭐⭐⭐⭐
- Kareem Hunt Over 49.5 rushing yards (-110 via bet365) ⭐⭐⭐⭐
NFL picks made Friday; odds subject to change. Our NEW NFL player prop odds tool can help you find the best odds on any market across legal sportsbooks in your area!
Odds as of Friday and subject to change.
Chiefs vs. 49ers touchdown pick
George Kittle anytime touchdown scorer (+165) ⭐⭐⭐
Kittle has scored at least one touchdown in four consecutive contests. Considering his success finding the end zone this season, it’s surprising to see such long odds here.
He's the only player involved in this game with more than three touchdowns this season. The Chiefs are allowing 1.4 passing touchdowns per game. And yet, there are six-to-seven players with better odds to score a touchdown than him on Sunday among our best sportsbooks.
FanDuel is offering a price of +165, which implies a 37.74% chance that Kittle scores.
Meanwhile, DraftKings is featuring odds of +135, which implies a 42.55% chance. The DraftKings number seems much more reasonable, which means the FanDuel price provides legitimate value for one of your NFL Week 7 predictions.
Best odds: +165 via FanDuel | Implied probability: 37.74%
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Best Chiefs vs. 49ers prop bets
Travis Kelce Over 6.5 receptions (+135) ⭐⭐⭐⭐
Kelce has started to look like the player we all expected him to be since Rice's injury.
He had logged just eight catches for 69 yards through the first three weeks. Then Kelce snagged seven catches for 89 yards in the game when Rice was injured. And last week Kelce turned nine receptions into 70 yards.
The pass-catcher has been targeted 19 times over the past two games. The next highest mark on the team is 10 for Xavier Worthy. The 49ers boast a solid pass defense, but they did allow Kelce to catch nine passes for 93 yards in last year’s Super Bowl.
This total is actually set at 5.5 through all of our best sports betting sites. But the price for the Over is -145 or worse everywhere.
Therefore, I recommend taking Kelce at +135 to record at least seven catches. After all, if the 49ers keep Kelce below seven catches, then it’s likely their game plan worked and they limit him to five or fewer, too.
Best odds: +135 via bet365 | Implied probability: 42.55%
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Kareem Hunt Over 49.5 rushing yards (-110) ⭐⭐⭐⭐
Hunt has notched 41 carries for 171 yards since joining the Chiefs, and he’s averaging 4.2 yards per carry. He ran the ball 27 times for 102 yards and a touchdown during the Chiefs' last game.
The 49ers boast the seventh-best run defense in the NFL, allowing just 101 rushing yards per game. However, they’re giving up 4.4 yards per carry, which ranks in the middle of the league. The 49ers have played with huge leads this season, and their run defense looks better than it really is because of those game scripts.
BetMGM and bet365 have each set this total at 49.5, and bet365 is offering the better price of -110 for the Over. The other three best sports betting apps are setting the total set at 52.5.
Best odds: -110 via bet365 | Implied probability: 52.83%
Chiefs vs. 49ers game info
- When: Sunday, Oct. 20
- Kickoff: 4:25 p.m. ET
- Where: Levi’s Stadium, Santa Clara, CA
- How to watch: FOX
- Weather: 82 degrees, 10% chance of precipitation, wind 10-mph NW
- Favorite: 49ers -1.5 (-110 via BetMGM)
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