Browns vs. Eagles Predictions, Odds & Expert Picks: NFL Preseason Week 2

The Browns' offense looked great with Shedeur Sanders last week but will be without the rookie passer against the Eagles on Saturday.

Mike Spector

Last Updated: August 15, 2025 10:16 AM EDT • 4 minute read

Browns vs. Eagles Predictions, Odds & Expert Picks: NFL Preseason Week 2 — Pictured: Head coach Nick Sirianni talks with quarterback Tanner McKee (16) as we make our best Browns vs. Eagles predictions. Photo by Bill Streicher via Imagn Images.

After rookie Shedeur Sanders suffered an oblique injury earlier in the week, the Cleveland Browns’ quarterback situation entering this game against the defending Super Bowl champion Philadelphia Eagles suddenly got murkier. We analyze what that means for Cleveland’s chances with our Browns vs. Eagles predictions.

The Eagles are anywhere from 3.5- to 4.5-point home favorites at our top sports betting sites, and we make our best ATS and O/U wagers as part of our NFL preseason Week 2 predictions. Kickoff from Lincoln Financial Field is set for 1 p.m. ET and is the featured game on NFL Network.

🏈 Browns vs. Eagles predictions & expert picks

🔎 Our NFL player prop odds tool can help you find the best NFL odds across legal sportsbooks in your area to make your NFL picks!

✅ Against the spread pick: Eagles -3.5 (-115 via FanDuel) ⭐⭐⭐
✅ My best bet: Under 37.5 (-115 via BetMGM) ⭐⭐⭐

🔮 Browns vs. Eagles ATS prediction

🦅 Eagles -3.5 ⭐⭐⭐

📊 Best odds: -115 via FanDuel ($10 to win $8.70)
🔢 Implied probability: 53.49%

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The Browns have been the talk of the NFL over the past week, with Sanders’ inspired performance being a big reason they scored 30 points in the preseason opener. But we are using that buzz to fade what should be a popular pick, giving more faith to Philadelphia’s overall depth.

The Eagles beat the Cincinnati Bengals 34-27 in their preseason opener, clawing back from a 14-7 deficit after Cincinnati’s starters scored two quick touchdowns in the first quarter. The Eagles went on a 27-3 run from there, as quarterback Tanner McKee completed 80% of his passes and three running backs ran for 5.3 yards per carry or better.

Only one team (the New England Patriots) scored more points than Philadelphia last week, and its depth down to the second- and third-string units is why I agree with this line movement from an opening number of -1.5.

While other top sports betting apps like DraftKings moved to -4.5 after Sanders’ injury news, I am making this wager at the lone sportsbook still offering a spread under four points.

📖 Check out our 2025 NFL preseason betting guide for the best betting strategies and full NFL preseason schedule.

💰 Browns vs. Eagles best bet

⬇️ Under 37.5 ⭐⭐⭐

📊 Best odds: -115 via BetMGM ($10 to win $8.70)
🔢 Implied probability: 53.49%

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With still some uncertainty about how each team’s quarterback plans will shake out, I am fading the public perception and backing the Under on a game in which both teams scored a combined 64 points the week prior.

This becomes a more confident four-star play if news breaks that Dillon Gabriel will get the start for Cleveland instead of the veteran Joe Flacco or Kenny Pickett. Gabriel went 1-for-5 passing with an interception in these teams’ second joint practice, whereas Flacco completed 70% of his passes with a 2-0 TD-INT ratio.

With Sanders already showing his capabilities last week, the pressure is on Gabriel to perform. I also expect slight regression from McKee, who finished with the ninth-highest EPA per dropback among quarterbacks who had a minimum of seven dropbacks in Week 1.

📊 Browns vs. Eagles odds

Live updated odds from our best live betting sites. Follow the latest NFL scores for line history and matchup info.

🪧 Browns vs. Eagles opening odds:

Browns: +1.5 (-105)
Eagles: -1.5 (-115)

🚑 Browns vs. Eagles injuries

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Written by:
Mike Spector

Mike started in the sports writing industry in July 2019, and gained a lot of followers in his first year after finishing with the No. 2 overall record in an annual NFL betting competition, which made picks against the spread, and from an Over/Under and moneyline perspective. Mike is an avid fan of the NFL, MLB, tennis, and all college sports. In his opinion, March Madness is the best sporting event there is, and he's especially euphoric starting with conference tournament time in college basketball. Mike's a big advocate of "fading the public" and making plays that are contrarian, constantly citing that "there are reasons why they have those big shiny buildings in Las Vegas." When making wagers, Mike always scours the best odds at all of the major sports betting sites, where he mostly sifts through DraftKings, FanDuel, BetMGM, and bet365. He's tried several others and is of the firm belief that bettors should not just stick to one sportsbook, as there is always likely better value to be had with the same wager. In addition, while Mike received his undergraduate degree from Villanova University, he has no issue betting against the Wildcats when it comes to college basketball wagering, and suggests other bettors should always put their “head” before their “hearts.”