49ers vs. Seahawks Prediction, Picks & Odds for Thanksgiving: Defense to Shine in Nightcap
We anticipate a closely contested divisional game on Thursday night as San Francisco faces Seattle in a Thanksgiving nightcap, and we have our prediction for the 49ers vs. Seahawks based on the best NFL odds.
The Seattle Seahawks (6-4) host the San Francisco 49ers (7-3) in a Thanksgiving finale with significant playoff implications. The 49ers are among the front-runners in the Super Bowl odds, while the Seahawks are trying to keep up in the NFC West.
The potential for a low-scoring battle on Thursday night is heightened, especially with Chase Young contributing to the Niners' defensive strength. We discuss this further in our Brock Purdy player props.
As part of our Thanksgiving coverage and Week 12 predictions, we have our 49ers vs. Seahawks player props and our best 49ers vs. Seahawks prediction for Thanksgiving (odds via our best NFL betting sites; pick confidence based on a 1-to-5-star scale).
49ers vs. Seahawks prediction: Thanksgiving
Under 43.5 (-110 via DraftKings) ⭐⭐⭐
You can’t get much closer to the middle of the pack on totals trends in the NFL this season than a matchup between the 49ers and Seahawks. San Francisco has seen the Over go 5-5 in its games, while the Over is 5-4-1 in games involving Seattle.
The script for Seahawks games has seen vast variation this season, with the majority of their contests featuring lower scores, but a select few bursting through with totals into the 50s or even 60s on a couple of occasions. Over their past seven games, Seattle has scored above 24 points just once.
Seattle's games against divisional opponents have averaged just 35.3 total points so far this season but none of those three matchups were against the 49ers’ electrifying offense. San Francisco, though, has recently kept game totals low on the strength of its top-ranked scoring defense.
The 49ers allow just 15.7 points per game and have seen four of their past five contests finish with 41 or fewer points. As long as this total doesn’t dip below 43 points, there's value on the Under in this matchup, as Seattle should struggle to pour on many points against the surly San Francisco defense.
Our Anthony Wootton believes the 49ers' star running back is positioned to go off in a low-scoring game in his Christian McCaffery player prop picks.
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49ers vs. Seahawks best odds
DraftKings (-110)
| DraftKings | FanDuel | BetMGM | Caesars | bet365 |
|---|---|---|---|---|
| Under 43.5 | Under 42.5 | Under 43 | Under 43 | Under 43 |
| -110 | -108 | -110 | -110 | -110 |
The majority of our best sports betting apps list the total at 43 points, with BetMGM, Caesars, and bet365 matching one another with -110 odds on that line. FanDuel offers a less favorable line for Under bettors at 42.5, but you do see more profitable odds at -108.
DraftKings has the best combo for Under bettors on the odds and line, with the number at 43.5 with standard -110 odds on Under. We prefer to see this line at least at 43 to maintain a three-star recommendation on the Under.
49ers vs. Seahawks odds
49ers vs. Seahawks odds analysis
The 49ers opened as four-point road favorites and have ballooned to between -6.5 and -7 across our best sports betting sites. Nearly 60% of wagers have been placed on San Francisco.
The total opened at 44.5 and has dipped to between 42.5 and 43.5 across our best sportsbooks. Bettors seem to be jumping in on the lower prices, though, as 70% of wagers have gone Over.
49ers vs. Seahawks game info
- When: Thursday, Nov. 23, at 8:20 p.m. ET
- Where: Lumen Field in Seattle, WA
- How to watch: NBC
- Weather: 42 degrees, 5 mph winds, 5% chance of precipitation
49ers-Seahawks prediction made Monday at 4:45 p.m. ET.
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