49ers vs. Rams Player Props, Odds: Aiyuk to Step up for Injury-Riddled Niners

The injury-riddled Los Angeles Rams will try to upset the San Francisco 49ers on Sunday. The Niners are suffering from plenty of their own injuries too, but they still sit second in the Super Bowl odds.

Christian McCaffrey. Deebo Samuel. Cooper Kupp. Puka Nacua. Those are just four of the huge names who won’t be suiting up for Sunday’s game, and it's also not looking good for George Kittle. With so many key players out for both teams, determining the best 49ers vs. Rams player props based on the odds from our top NFL prop betting sites is no easy task.

Both teams still boast healthy quarterbacks this week. Brock Purdy, who's ninth in the NFL MVP odds, entered Week 2 with the most passing yards, and Matthew Stafford ranked second, just 17 yards behind him.

Will both signal-callers continue to play well even with so many injuries around them?

49ers vs. Rams NFL player prop bets: Sunday

Odds as of Friday and subject to change.

• Matthew Stafford Over 0.5 interceptions (-130 via bet365) ⭐⭐⭐⭐
• Brandon Aiyuk Over 69.5 receiving yards (-110 via BetMGM) ⭐⭐⭐⭐
• Kyren Williams Under 67.5 rushing yards (-110 via DraftKings) ⭐⭐⭐⭐

NFL picks made Friday; odds subject to change. Our NEW NFL player prop odds tool can help you find the best odds on any market across legal sportsbooks in your area!

Matthew Stafford Over 0.5 interceptions (-130) ⭐⭐⭐⭐

All of our best sports betting sites are rightfully favoring Stafford to throw an interception this week.

He didn’t throw any interceptions last week, but the Arizona Cardinals’ defense is poor. The passer threw a really ugly pick against the Detroit Lions in Week 1, and Stafford was lucky he didn’t toss more.

The Rams’ offensive line is in bad shape right now, and Stafford is going to be under duress for the entire game. He’s already been sacked seven times this season.

Without either of his two main targets available to help bail him out, Stafford will force at least one too many passes and the 49ers will take advantage.

Best odds: -130 via bet365 | Implied probability: 56.52%

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Brandon Aiyuk Over 69.5 receiving yards (-110) ⭐⭐⭐⭐

Aiyuk is off to a rough start this season. He's registered just six catches for 71 yards, and the veteran is the fourth-leading receiver on the 49ers entering Week 3.

But now Aiyuk gets to face a really depleted secondary. Additionally, we know Samuel is out, and Kittle didn’t practice on Thursday.

The Rams’ defense allowed Marvis Harrison Jr. to pull down four catches for 130 yards and two touchdowns last week. The performance came one week after Harrison only managed one catch in his NFL debut.

Without many options, Brock Purdy will target Aiyuk a lot, and the pass-catcher will be the second straight receiver to find himself against this defense.

Some of our best sports betting apps are listing this total as high as 72.5, and others are favoring the over at 70.5. So getting this for -110 at 69.5 leads to phenomenal value for your NFL Week 3 predictions.

Consider taking this as the safe play before finding a solid price in for Over 79.5 yards.

Best odds: -110 via BetMGM | Implied probability: 52.38%

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Kyren Williams Under 67.5 rushing yards (-110) ⭐⭐⭐⭐

The 49ers are allowing 5.0 yards per carry to start the season. That could be good for Williams, especially in a game when he’s unlikely to receive many carries. However, Williams is only averaging 2.5 yards per carry to start the campaign.

Williams has only gained 75 rushing yards this season. He hasn’t gone over 50 yards yet in a game. While the 49ers definitely have some weaknesses, Williams isn’t running well enough to exploit their defense. Add in that the Rams are likely to be trailing the entire game, and the outlook isn't good for Williams.

Three of the five best live betting sites are setting this total at 65.5 yards, and they’re all asking more than -110 to back the Under. Getting this two yards higher for a better price is a steal.

Best odds: -110 via DraftKings | Implied probability: 52.38%

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49ers vs. Rams odds

See all of this week's NFL odds and NFL scores.

49ers vs. Rams game info

• When: Sunday, Sept. 22
• Kickoff: 4:25 p.m. ET
• Where: SoFI Stadium, Inglewood, CA
• How to watch: FOX
• Weather: Indoors
• Favorite: 49ers (-295 via FanDuel)

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