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Josh Allen #17 of the Buffalo Bills reacts during the first half of the game against the Kansas City Chiefs as we look at the Week 15 odds.
Josh Allen #17 of the Buffalo Bills reacts during the first half of the game against the Kansas City Chiefs at GEHA Field at Arrowhead Stadium on December 10, 2023 in Kansas City, Missouri. Photo by Jamie Squire/Getty Images via AFP.

There is a trio of Saturday games highlighting the slate for the first time this season as we take an initial peek at the NFL Week 15 odds and betting lines from our best NFL betting sites.

The NFL Week 15 slate began with a Thursday Night Football matchup between the Las Vegas Raiders and Los Angeles Chargers. The Raiders scored a franchise record with the 63-21 victory; the Chargers fired head coach Brandon Staley on Friday.

Saturday features a contest between the Pittsburgh Steelers (7-6) and Indianapolis Colts (7-6) — two teams vying for the final wild-card spots in the AFC.

The game most likely to shake up the Super Bowl odds is a Sunday afternoon affair between the Dallas Cowboys and Buffalo Bills. Buffalo was among the preseason favorites to win the AFC but finds itself outside the postseason picture despite picking up a key victory over the Kansas City Chiefs in Week 13. The Cowboys continue to climb the oddsboard as winners of five straight.

Eyes will also be on the Philadelphia Eagles vs. Seattle Seahawks on Monday Night Football, with Philly vying for the No. 1 seed in the NFC.

Here’s a closer look at all of the NFL Week 15 odds from our best sports betting sites.  

NFL Week 15 odds and lines

There's an advantage to betting the early NFL odds while trying to beat the closing line. The closer you wait until kickoff to make your NFL picks, the more difficult it becomes to identify edges and secure the best number on most sides or totals.

That's why it's important to start monitoring the NFL opening odds each week as soon as possible. A proactive approach is the first step to long-term success.

Best NFL Week 15 spreads

(Odds via Caesars)

GameSpread (Dec. 15)Spread (Dec. 11)Opening Spread (Dec. 6)
Vikings vs. BengalsBengals -3Bengals -3.5Bengals +1
Steelers vs. ColtsColts -1.5Colts -2.5Colts -3
Broncos vs. LionsLions -4.5Lions -3.5Lions -4.5
Bears vs. BrownsBrowns -3Browns -3Browns -2.5
Buccaneers vs. PackersPackers -3.5Packers -3.5Packers -3.5
Texans vs. TitansTitans -4Titans -2Titans +3.5
Jets vs. DolphinsDolphins -9.5Dolphins -12Dolphins -13.5
Chiefs vs. PatriotsPatriots +8Patriots +9.5Patriots +10
Giants vs. SaintsSaints -5.5Saints -6.5Saints -6
Falcons vs. PanthersPanthers +3Panthers +3Panthers +2.5
Commanders vs. RamsRams -6.5Rams -6Rams -6
49ers vs. CardinalsCardinals +12.5Cardinals +13.5Cardinals +13.5
Cowboys vs. BillsBills -2Bills -1.5Bills -1
Ravens vs. JaguarsJaguars +3Jaguars +3Jaguars +6
Eagles vs. SeahawksSeahawks +3Seahawks +3.5Seahawks +4

A whopping eight home underdogs peppered the opening lines for the Week 15 slate, but Week 14 has flipped the switch on some, and that number has dropped to five. Injuries to Chargers QB Justin Herbert and Texans QB C.J. Stroud, coupled with Bengals QB Jake Browning performing well again, are responsible for the biggest moves. You can take advantage of any of the spreads by using our Caesars promo code: SBRBONUS1000

Only three games on the week feature spreads of greater than seven points, and two have steadily moved closer to that mark over the week. Only the 49ers giving up 12.5 points to the Cardinals remains lined with a spread larger than 10 points.

Seven games have a margin at or less than a field goal, with the tightest game of the week being the Colts giving up 1.5 points at home to the Steelers.

Best NFL Week 15 moneylines

(Odds via bet365)

The Chiefs, Saints, Dolphins, 49ers, and Rams are the largest favorites looking ahead to Week 15. Like with the spreads, we've seen underdogs flip to favorites with quarterback injuries to Herbert and Stroud.

Best NFL Week 15 Over/Unders

(Odds via FanDuel)

Due to quarterback play and injuries, totals nearing 50 have been few and far between over the back half of the season, and we saw that again in the opening Over/Unders for Week 15. As the week has progressed, two games have been bet up to that benchmark: the Commanders-Rams and Cowboys-Bills.

Just one game is in the key range of 43-44, while six of the seven games on the early Sunday slate have totals below 40.

NFL betting odds pages

Here are our best NFL betting sites:

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