NFL Week 13 Odds & Betting Lines: Spread, Moneyline, Over/Under for All 16 Games

The Week 13 NFL odds are out, and we have a full slate for the first time in what feels like a lifetime. But don't get too used to that because we have to stretch bye weeks into Week 14, It's ridiculous, but we'll deal with that when we get there. 

Our NFL betting sites will have a busy week with games spread over four days, including a Thanksgiving triple-header, and a Black Friday tussle.

• The week gets underway with a Thanksgiving triple-header:
• The Chicago Bears and Detroit Lions square off in a holiday classic (12:30 p.m. ET, CBS)
• An NFC East tilt between two underperforming squads as the New York Giants visit the Dallas Cowboys (4:30 p.m. ET, FOX)
• The Miami Dolphins visit the Green Bay Packers (on a Thursday night, but not officially a Thursday Night Football odds tilt) in a game with major playoff implications (8:20 p.m. ET, NBC/Peacock/Universo)
• The Super Bowl odds contending Kansas City Chiefs host the Las Vegas Raiders on Black Friday (3 p.m. ET, Prime Video)
• The Sunday Night Football odds show an absolute banger between the San Francisco 49ers and Buffalo Bills, led by NFL MVP odds favorite Josh Allen (8:20 p.m. ET, NBC/Peacock)
• The Monday Night Football odds have a surprise NFL playoff odds contender in action as the Denver Broncos welcome the Cleveland Browns (8:15 p.m. ET, ESPN)

NFL Week 13 odds and lines

There's an edge to betting NFL odds while trying to beat the closing line. The closer you wait until game time to make your NFL picks, the more difficult it becomes to identify advantages and secure the best number on most side bets or totals.

That's why it's important to start monitoring the NFL opening odds each week as soon as possible. A proactive approach will aid your long-term success.

Best NFL Week 13 spreads

(Odds via DraftKings)

• Divisional rivalry games: Bears-Lions (Thanksgiving), Giants-Cowboys (Thanksgiving), Raiders-Chiefs (Black Friday), Texans vs. Jaguars, Steelers vs. Bengals, Buccaneers vs. Panthers
• Five of the 13 games have opened with the home squad listed as the underdog
• That number has grown to six as of Wednesday morning with the Jets moving to underdogs
• Eight games are lined with a spread of three or fewer points to open
• That number has shrunk to six, with the Cowboys moving from -2.5 to -3.5 and the Bills going from -3 to -7
• ATS leaders heading into Week 13: Lions (9-2), Broncos (9-3), Steelers (8-3), Vikings (7-3-1), Colts (8-4)
• ATS losers heading into Week 13: Titans (2-9), Cowboys (3-8), Giants (3-8), Jets (3-8)

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Best NFL Week 13 moneylines

(Odds via FanDuel)    

Here are the biggest questions we had heading into last week, and the answers (along with how they've impacted the lines)

• The Bears likely can't keep up with the Lions on Thanksgiving, but will the offense show continued improvement in their second game with a new OC?
• It was another positive performance from QB Caleb Williams and the offense, scoring 27 points in an overtime loss to the Vikings; the Lions still pulled further away heading into Week 13
• Tommy DeVito is taking over under center for the Giants - will that make any difference at all to the outlook of their game against the Cowboys?
• Yeah, it was somehow even worse than Daniel Jones; the Cowboys are even bigger favorites, going from -144 to -215 after DeVito's performance and the Cowboys upset of the Commanders
• How will the Chiefs bounce back from their first loss of the year?
• It was another nailbiter from the Chiefs, who only put away the 3-8 Panthers on the final drive of the game in a 30-27 win; they've pulled even further away after the Raiders QB Gardner Minshew suffered a season-ending injury
• How will the Ravens bounce back from an awful output in a key divisional game loss in Week 11?
• It was a bit of a slow start for the Ravens, putting up a goose eggs in the opening quarter before racking up 30 points in a MNF victory over the chargers

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Best NFL Week 13 Over/Unders

(Odds via bet365)   

• Over leaders heading into Week 13: Ravens (10-2), Bengals (8-3), Panthers (8-3), Raiders (8-3), Commanders (8-4)
• Under leaders heading into Week 13: Giants (3-8), Texans (4-8), Chargers (4-7), Bears (4-7), Vikings (4-7), Falcons (4-7)
• Opening market highs: Eagles-Rams (50.5) is the only game north of 48 points
• This has been moved to 51 as of Wednesday morning
• Opening market lows: Only the Giants and Cowboys (39.5) on Thanksgiving has opened at under 40 points
• It remains the low heading into Week 13, dropping to 37 points, and is the only game lower than 40 points

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