NFL Odds & Week 1 Schedule | Betting Lines, Spreads and Totals for Every Game
📊 NFL odds Week 1, 2026
The NFL odds for Week 1 are via bet365.
| Game | Spread | Moneyline | Over/Under |
|---|---|---|---|
| Patriots vs. Seahawks (Wednesday) | Seahawks -3.5 | NE +155 / SEA -185 | 44.5 |
| 49ers vs. Rams at Melbourne (Thursday) | Rams -3.5 | SF +160 / LAR -190 | 48.5 |
| Falcons vs. Steelers | Steelers -3.5 | ATL +155 / PIT -185 | 41.5 |
| Ravens vs. Colts | Ravens -3.5 | BAL -180 / IND +150 | 48.5 |
| Bills vs. Texas | Bills -1.5 | BUF -115 / HOU -105 | 44.5 |
| Bears vs. Panthers | Bears -2.5 | CHI -155 / CAR +130 | 46.5 |
| Browns vs. Jaguars | Jaguars -8.5 | CLE +325 / JAX -425 | 40.5 |
| Saints vs. Lions | Lions -6.5 | NO +250 / DET -310 | 49.5 |
| Jets vs. Titans | Titans -1.5 | NYJ +105 / TEN -125 | 39.5 |
| Buccaneers vs. Bengals | Bengals -3.5 | TB +165 / CIN -200 | 50.5 |
| Cardinals vs. Chargers | Chargers -9.5 | ARI +400 / LAC -550 | 47.5 |
| Packers vs. Vikings | Vikings -1.5 | GB +100 / MIN -120 | 46.5 |
| Dolphins vs. Raiders | Raiders -3.5 | MIA +155 / LV -185 | 40.5 |
| Commanders vs. Eagles | Eagles -5.5 | WAS +190 / PHI -230 | 44.5 |
| Cowboys vs. Giants (SNF) | Cowboys -2.5 | DAL -155 / NYG +130 | 48.5 |
| Broncos vs. Chiefs (MNF) | Chiefs -2.5 | DEN +125 / KC -150 | 43.5 |
Our NFL picks will be locked and loaded for Week 1 as we get ready for the season's opening week.
- The season starts with a Super Bowl rematch between the Patriots and Seahawks on Wednesday at 8:20 p.m. ET (Lumen Field, Seattle, NBC) - the league's first Wednesday game since 202
- The league heads "Down Under" for the 49ers and Rams in Melbourne, Victoria (Melbourne Cricket Ground, 8:35 p.m. ET, Netflix)
- We have a 13-game Sunday slate with games starting at 1 p.m. ET
- The largest spread of the slate: Chargers -9.5 vs. Cardinals (4:25 p.m. ET, SoFi Stadium, CBS)
- The largest total of the slate: Buccaneers vs. Bengals comes with a 50.5 total (1 p.m. ET, Paycor Stadium, FOX)
- Sunday Night Football sees the Cowboys as 2.5-point betting favorites over the Giants at MetLife Stadium (8:20 p.m. ET, NBC)
- Monday Night Football has the Chiefs a 2.5-point betting favorite over the Broncos at Arrowhead Stadium (8:15 p.m. ET, ESPN/ABC)
🏈 Patriots vs. Seahawks: Season-opening game
- Kickoff: 8:20 p.m. ET from Lumen Field (Seattle)
- How to watch: NBC
🏈 49ers vs. Rams: Thursday in Australia
- Kickoff: 8:35 p.m. ET from Melbourne Cricket Ground (Melbourne, Victoria)
- How to watch: Netflix
🏈 Cowboys vs. Giants: Sunday Night Football
- Kickoff: 8:20 p.m. ET from MetLife Stadium (East Rutherford, N.J.)
- How to watch: NBC
- Kickoff: 8:20 p.m. ET from MetLife Stadium (East Rutherford, N.J.)
- How to watch: NBC
🏈 Broncos vs. Chiefs: Monday Night Football
- Kickoff: 8:15 p.m. ET from Arrowhead Stadium (Kansas City, Mo.)
- How to watch: ESPN/ABC
📈 NFL Week 1 odds and lines
There's an advantage to betting early NFL odds when attempting to beat the closing line with your NFL predictions. The closer you wait until kickoff to make your picks, the harder it becomes to identify edges and secure the best price on most sides or totals.
📺 Who's playing on prime time in Week 1?
We have four prime-time games in the season's opening week. New England and Seattle cash in a Super Bowl rematch on Wednesday at 8:20 p.m. ET on NBC (it's the league's first Wednesday game in six years), and the Rams and 49ers battle in Australia on Thursday at 8:35 p.m. ET on Netflix. Then we have our standard Sunday Night Football at 8:20 p.m. ET on Sunday when the Giants host the Cowboys in an NFC East rivalry clash, and we wrap up with the Chiefs and Broncos in Kansas City on Monday Night Football.
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