NFL Parlay Picks Week 1: 3-Leg Parlay With +561 Odds
My NFL parlay picks for Week 1 like two of the highest totals of the weekend to sail Over their respective numbers due to a combination of motivated offenses and lackluster defenses in tantalizing scoring environments.
Plus, if you’ve counted Jayden Daniels and the Commanders out of the postseason picture before the season, you might want to reconsider before disrespecting No 5.
NFL parlay picks: Week 1
NFL odds via FanDuel as of Thursday and subject to change. Follow the NFL scores for the latest line movement and matchup info.
| 💰 Pick | 📊 Best odds |
|---|---|
| Saints-Lions Over 49.5 | -115 via FanDuel |
| Buccaneers-Bengals Over 50.5 | -112 via FanDuel |
| Commanders +5.5 | -115 via FanDuel |
Combined odds: +561 via FanDuel | Implied probability: 15.13%
Week 1 NFL parlay
NFL picks based on the odds from our best NFL betting sites. Our NEW NFL player prop odds tool can help you find the best odds on any market across legal sportsbooks in your area!
Saints-Lions Over 49.5 (-115)
Detroit averaged 28.3 points per game last season (4th in NFL) and had defensive deficiencies that contributed to its games going 10-7 on Overs.
Though the Saints were one of the most prominent teams for Unders last year, I see the late-season breakout of QB Tyler Shough as a positive sign for their growth offensively moving forward. In a dome for Week 1, I like gaudy offensive outputs on both sides of this matchup.
- Matchup: Saints vs. Lions
- When: Sunday, Sept. 13, 1 p.m. ET
- Where: Ford Field (Detroit)
- Favorite: Lions -6.5 (-122 via FanDuel)
Buccaneers-Bengals Over 50.5 (-112)
Two of the more defensive-optional operations from 2025 are matched up in Week 1 with veteran quarterbacks who both have something to prove in this new season. Joe Burrow’s time in Cincinnati feels tenuous if the Bengals can’t figure it out this year, while Baker Mayfield aims to show last year’s fall from the NFC South crown was an anomaly.
These sides combined to allow 53.1 PPG last season, and I like both offenses to tick up in 2026 compared to their beleaguered 2025 outputs.
- Matchup: Buccaneers vs. Bengals
- When: Sunday, Sept. 13, 1 p.m. ET
- Where: Paycor Stadium (Cincinnati)
- Favorite: Bengals -3.5 (-115 via FanDuel)
Commanders +5.5 (-115)
After a run to the NFC Championship the prior season, the Commanders crashed back down to earth in 2025. But a healthy Jayden Daniels has too much talent to stay down for long, and I like the new energy of first-time coordinators David Blough (offense) and Daronte Jones (defense).
After several off-season changes of their own, the Eagles should have a sharper season, too, but this spread at 5.5 points feels too high for a season-opening divisional game between two motivated sides.
- Matchup: Commanders vs. Eagles
- When: Sunday, Sept. 13, 4:25 p.m. ET
- Where: Lincoln Financial Field (Philadelphia)
- Favorite: Eagles -5.5 (-105 via FanDuel)
❓ NFL betting FAQs
What does the spread mean in betting NFL?
In NFL betting, the spread is the number of points a team is favored to win or lose by. It levels the playing field for bettors by giving an advantage or disadvantage in points. Bettors win if their pick covers the spread.
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Make sure you look at our top NFL betting sites to find the best odds for NFL Sunday. These sportsbooks include Caesars, BetMGM, bet365, FanDuel, and DraftKings.
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