College Football Week 2 AI Predictions: ATS Picks & Score Projections for Top 25 Games

College Football Week 2 features several massive non-conference matchups, and the AI predictions below break down 25 of the best games on the slate with against-the-spread picks and projected scores.

The headliner comes Saturday night when No. 1 Ohio State visits No. 5 Texas, while No. 10 Oklahoma travels to No. 16 Michigan and No. 20 Tennessee visits Georgia Tech. Friday's schedule also includes the Border War between No. 25 Missouri and Kansas.

The ChatGPT AI model considers Week 1 performance, returning production, advanced metrics, roster and coaching changes, injuries, matchup advantages, home-field edge, and current market movement. All ATS picks below use Kalshi's college football spread markets as of Thursday, Sept. 10.

Follow all of SBR's college football picks throughout the season and check the latest college football odds before kickoff.

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College Football Week 2 AI predictions

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Rutgers at Boston College AI prediction

Friday night's Big Ten-ACC matchup sets up well for Boston College at home. Rutgers should be able to keep the game physical and prevent it from becoming a track meet, but the Scarlet Knights may struggle to generate enough explosive offense if they fall behind. Boston College only needs to clear a relatively modest spread and should benefit from playing the game on its own terms. A few sustained second-half drives should be enough for the Eagles to create separation.

ATS pick: Boston College -3.5

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Missouri at Kansas AI prediction

Missouri opened its season with a comfortable 54-14 victory over Arkansas-Pine Bluff, but Friday's Border War presents a much more difficult road assignment. The Tigers have the deeper roster and deserve to be favored, yet laying nearly a touchdown in a rivalry game is less appealing. Kansas should be capable of generating enough offense to keep Missouri from pulling away, particularly with the Jayhawks at home. Missouri gets the narrow straight-up edge, but the points make Kansas the more attractive ATS side.

ATS pick: Kansas +5.5

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Oregon at Oklahoma State AI prediction

Oregon received a legitimate test from Boise State in a 34-27 Week 1 victory, which should leave the Ducks better prepared for their first road game. Oklahoma State now has to deal with an Oregon roster that can create explosive plays while also wearing opponents down with its depth. The Ducks remain one of the leading contenders in SBR's college football national championship odds, and this matchup gives them an opportunity to look the part. Oregon should turn a competitive start into a comfortable win.

ATS pick: Oregon -23.5

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Arizona State at Texas A&M AI prediction

Both teams dominated overmatched Week 1 opponents, with Arizona State beating Morgan State 70-7 and Texas A&M shutting out Missouri State 50-0. The Aggies have the stronger roster and a significant home-field advantage at Kyle Field, but a 14.5-point spread asks them to create substantial separation against another Power Four opponent. Arizona State doesn't need to threaten for the outright win to provide value. A couple of sustained scoring drives should be enough to keep the Sun Devils inside two touchdowns.

ATS pick: Arizona State +14.5

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Oklahoma at Michigan AI prediction

Oklahoma could hardly have started better, shutting out UTEP 51-0, while Michigan needed a dramatic finish to escape Western Michigan 13-12. That contrast has driven significant movement toward the Sooners, but nearly a touchdown is a big number at the Big House. Michigan's defensive front held up well despite the Week 1 scare and can make Oklahoma more dependent on John Mateer consistently winning through the air. SBR's full Oklahoma vs. Michigan prediction also backs the Wolverines as home underdogs.

ATS pick: Michigan +5.5

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Wake Forest at Purdue AI prediction

Wake Forest enters as a modest road favorite in a game that should reveal much more about both teams than their opening-week assignments. Purdue has home-field advantage, but Wake Forest looks better equipped to sustain drives and capitalize when possessions reach scoring territory. The 3.5-point spread is manageable if the Demon Deacons can avoid turnovers and keep Purdue from consistently creating short fields. Wake Forest's offensive edge should become more noticeable after halftime, leading to an eight-point road victory.

ATS pick: Wake Forest -3.5

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Appalachian State at East Carolina AI prediction

East Carolina faced a brutal opening assignment at Alabama and lost 48-10, so Week 2 offers a much more realistic measuring stick. The Pirates should be better offensively in this regional matchup, but laying more than a touchdown against Appalachian State creates little margin for error. App State has enough offensive capability to keep East Carolina from controlling the entire game and should remain within striking distance into the fourth quarter. The Pirates get the straight-up nod at home, but the Mountaineers are the preferred side with the points.

ATS pick: Appalachian State +7.5

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South Florida at Army AI prediction

Army's option offense is always difficult to prepare for early in the season, especially for an opponent with limited time to replicate its timing and physicality in practice. South Florida has enough athleticism to make this competitive, but the Black Knights should control possession and limit total drives. That becomes particularly valuable if Army gets ahead and forces USF to become more aggressive offensively. At only 3.5 points, the spread is small enough to back the home favorite.

ATS pick: Army -3.5

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Alabama at Kentucky AI prediction

Alabama looked sharp in a 48-10 win over East Carolina, but its first SEC road game presents a significantly different challenge. Kentucky can lean on its defense, home crowd, and a more conservative game script to keep Alabama from accumulating possessions. The Crimson Tide remain the clear straight-up choice and a contender in the College Football Playoff odds, but winning by nearly two touchdowns on the road is another matter. Kentucky should do enough to stay inside the number.

ATS pick: Kentucky +10.5

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Arizona at BYU AI prediction

BYU couldn't have asked for a much easier opener, beating Utah Tech 63-7, but Arizona provides a major step up in competition. The Cougars deserve to be favored in Provo and have the stronger home-field advantage, yet Arizona has enough offensive ability to turn this into a four-quarter Big 12 game. BYU may still control the matchup for long stretches, but covering more than a touchdown requires more separation than the projected game script provides. A six-point Cougars victory makes Arizona the ATS side.

ATS pick: Arizona +7.5

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Mississippi State at Minnesota AI prediction

This SEC-Big Ten matchup carries one of the smallest spreads on the board, and home-field advantage may ultimately be the difference. Minnesota should be comfortable turning this into a physical game and forcing Mississippi State to consistently execute on long drives rather than relying on explosive plays. The Bulldogs have enough talent to remain competitive, but Minnesota's ability to control the line of scrimmage and avoid negative plays provides the cleaner path. With the spread sitting below a field goal, the Golden Gophers are worth laying the short number.

ATS pick: Minnesota -1.5

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Duke at Illinois AI prediction

Illinois deserves to be favored at home, but this spread looks large for a matchup that should feature plenty of extended possessions. Duke can keep things manageable by protecting the football and preventing Illinois from consistently starting drives with advantageous field position. The Fighting Illini have enough defensive talent to win a relatively low-variance game, but pulling away by a touchdown or more is less certain. Illinois gets the straight-up prediction, while Duke's ability to keep the game competitive makes nearly a touchdown attractive.

ATS pick: Duke +5.5

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UCF at Pittsburgh AI prediction

Pittsburgh's home-field advantage and defensive front make the Panthers deserving favorites, but UCF should be capable of creating enough explosive offense to remain competitive. The Knights don't need to consistently march 75 yards if they can manufacture a few chunk gains and put pressure on Pitt to answer. Pittsburgh still has the more reliable path to victory, particularly late in the game, but 7.5 points is valuable in a matchup projected to remain within one possession. The Panthers win without covering.

ATS pick: UCF +7.5

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California at Syracuse AI prediction

California's defense faces a difficult road assignment against a Syracuse offense that should be much more comfortable operating at home. The Orange have an opportunity to dictate tempo and attack a Cal team that gave up too many explosive plays in its opener. Syracuse still needs to avoid turnovers, but the matchup provides enough offensive advantages to justify laying a short number. Cal should generate points of its own, particularly as the game opens up, but Syracuse has the better chance to consistently finish drives.

ATS pick: Syracuse -3.5

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UTSA at Texas State AI prediction

Texas State is a slight home favorite in the latest Kalshi market, but this looks like one of the better outright upset opportunities on the slate. The Bobcats are coming off a 59-7 loss at Texas and now face a UTSA team much closer to their own level. The Roadrunners should be able to generate significantly more offensive success than Texas State allowed itself to establish last week, and this rivalry has the potential to become high-scoring quickly. Getting points with UTSA adds value to a matchup it can win outright.

ATS pick: UTSA +2.5

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UNLV at North Texas AI prediction

UNLV gets a favorable opportunity to bounce back offensively against a North Texas defense that was overwhelmed in a 52-16 loss to Indiana. The Rebels should be able to create explosive plays both on the ground and through the air, putting pressure on North Texas to keep pace rather than settling into a comfortable offensive rhythm. The Mean Green can score enough to prevent this from becoming a blowout, but UNLV has the stronger two-way profile. At less than a touchdown, the Rebels are worth backing on the road.

ATS pick: UNLV -3.5

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Memphis at Boise State AI prediction

Boise State acquitted itself well in a 34-27 loss at No. 2 Oregon, and returning home should make the Broncos difficult to beat. The concern is the number. Memphis has enough offensive talent to keep this game within striking distance, while Boise showed last week that it can compete with elite opponents without necessarily controlling them. The Broncos remain one of the Group of Six programs highlighted in SBR's latest College Football Playoff odds analysis, but 9.5 points is too much here.

ATS pick: Memphis +9.5

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Jacksonville State at Ohio AI prediction

Jacksonville State and Ohio provide one of the more balanced Group of Five matchups on Saturday, with Kalshi making the Bobcats a short home favorite. Jacksonville State can make this uncomfortable if its rushing attack consistently stays ahead of the chains, but Ohio's home-field advantage and more balanced offensive approach should ultimately matter. A spread below a field goal would be preferable, but Ohio has enough of an edge to create a one-score cushion late rather than relying on a last-second result.

ATS pick: Ohio -2.5

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South Alabama at Tulane AI prediction

Tulane is a substantial favorite and should win at home, but South Alabama getting double digits is the more appealing side. The Jaguars have enough offensive ability to produce several scoring drives and prevent Tulane from completely dictating the game. The Green Wave should have the advantage at the line of scrimmage and in overall depth, yet a 9.5-point spread requires them to create separation throughout the second half. A seven-point Tulane victory feels more realistic than a runaway.

ATS pick: South Alabama +9.5

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Tennessee at Georgia Tech AI prediction

Tennessee made quick work of Furman in a 56-9 opener and possesses significantly more overall talent than Georgia Tech. The spread, however, already prices in much of that advantage. Georgia Tech can create problems with its rushing attack and should be more competitive at home than Tennessee's Week 1 opponent was. The Volunteers have the offensive ceiling to pull away, but they may need to score into the 40s to comfortably cover 13.5. An eight-point road victory keeps Georgia Tech inside the number.

ATS pick: Georgia Tech +13.5

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San Diego State at UCLA AI prediction

UCLA's offense enters Week 2 with some momentum after putting up 45 points against Cal, and San Diego State faces a significant step up after its opening matchup. The Bruins should be able to push the pace and create enough explosive gains to make San Diego State play from behind, which is not the Aztecs' preferred setup. UCLA still has to avoid giving away possessions, but the offensive matchup gives the Bruins one of Saturday's clearer paths to a multi-score victory.

ATS pick: UCLA -13.5

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Ohio State at Texas AI prediction

The biggest game of Week 2 is essentially a pick'em, which makes home field particularly important. Ohio State has beaten Texas in each of the last two seasons, but Arch Manning finished 2025 playing much better football and now gets the Buckeyes in Austin. Ohio State still has perhaps the best individual player in the country in Jeremiah Smith, making this a matchup with virtually no margin for error. SBR's complete Ohio State vs. Texas prediction also favors the Longhorns to get revenge.

ATS pick: Texas -1.5

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Iowa State at Iowa AI prediction

Iowa looked dominant defensively in a 40-0 Week 1 win over Northern Illinois, but 16.5 points is an enormous number for the Cy-Hawk rivalry. These games routinely take on a lower-scoring, possession-by-possession feel, making it harder for the favorite to create the margin needed to cover a number this large. Iowa's defense and home field still provide the better route to the outright win, but Iowa State doesn't need to produce much offense to stay within two touchdowns.

ATS pick: Iowa State +16.5

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Texas Tech at Oregon State AI prediction

Texas Tech is a massive favorite after opening with a 33-10 victory over Abilene Christian, while Oregon State dropped its opener 33-20 to Houston. The Red Raiders are clearly the stronger team and one of the more prominent Big 12 contenders, but laying more than 27 points on the road is an entirely different proposition. Oregon State can lose comfortably and still cover this spread, particularly if Texas Tech begins emptying the bench with a significant second-half lead. The Beavers offer value purely because of how extreme the number has become.

ATS pick: Oregon State +26.5

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Arkansas at Utah AI prediction

Utah made an emphatic opening statement with a 66-14 win over Idaho and now gets an SEC opponent at Rice-Eccles Stadium. Arkansas has considerably more talent than the Utes' Week 1 opponent, but Utah's physicality and home-field advantage make this a difficult road environment. The Utes should be able to pressure Arkansas into long-yardage situations while controlling enough of the game on the ground to protect a second-half lead. Utah also appears in SBR's college football national championship odds as an intriguing long shot.

ATS pick: Utah -13.5

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