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With three of the top quarterbacks and vertical attacks in the league resting while on bye, we needed to dig a little deeper when making our best NFL receiving player prop predictions for Week 10. We look for the best NFL odds from our best NFL prop betting sites when making all our NFL picks.

Tennessee Titans wide receiver DeAndre Hopkins has a cushy matchup against the second-worst pass defense in football, but can Tennessee rookie quarterback Will Levis take advantage and help Hopkins have a huge game?

In an anticipated high-scoring matchup, Detroit Lions tight end Sam LaPorta is set to face the Los Angeles Chargers, who have shown vulnerability against tight ends. This positions LaPorta to potentially play a significant role for the Lions, exploiting the Chargers' susceptibility to tight end plays. The game presents an opportunity for LaPorta to contribute substantially, given the favorable matchup and the Chargers' past struggles defending against tight ends.

Finally, Baltimore Ravens tight end Mark Andrews may be an important safety net for his quarterback in a tough divisional matchup against the Cleveland Browns.

Check out our NFL Week 10 predictions and Week 10 best bets, along with our Week 10 NFL props to accompany our best NFL receiving player prop predictions for Week 10 (odds via our best NFL betting sites; pick confidence based on a 1-to-5-star scale).

NFL receiving prop predictions for Week 10

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Receiving player props

DeAndre Hopkins Over 60.5 receiving yards (-110 via bet365) ⭐⭐⭐⭐

There is quite a bit of disagreement between our best sports betting apps about what the number for this prop should be. FanDuel is offering Over 59.5 yards for -114, DraftKings is offering Over 60.5 for -120, Caesars is offering the same total for -133, and BetMGM is offering over 60.5 for -115. When you consider all five lines, bet365 offers the most value.

Hopkins has four catches in each game started by Will Levis. While their first performance together resulted in Hopkins accumulating 128 yards and three touchdowns, Hopkins ended with just 60 yards last week.

However, Hopkins also had 11 targets last week, and we think he will see plenty again on Sunday. The Tampa Bay Buccaneers have the second-worst pass defense in football. Levis and Hopkins are going to take advantage of that.

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Sam LaPorta Over 51.5 receiving yards (-110 via bet365) ⭐⭐⭐⭐

The Detroit Lions have a lot of offensive weapons, but that hasn’t prevented LaPorta from being an integral part of the offense every week. He has at least three catches for 36 yards in every game this season. He’s gone Over 50 yards five times, and he has been targeted at least five times in all but one of his games.

The Los Angeles Chargers have allowed 552 receiving yards to tight ends this season. That’s the third-most in the league. Sunday’s game between the Lions and Chargers is going to be a high-scoring back-and-forth affair. That bodes well for a big game from LaPorta.

Currently, bet365, DraftKings, and BetMGM offer the same total for the same price. Caesars has the Over of 51.5 listed with a price of -119, while FanDuel has the over listed at 52.5 for -114. Yesterday, all of our best sports betting sites had this number at 50.5, so we recommend getting in soon, as it will only continue to increase.

Mark Andrews Over 4.5 receptions (+130 via bet365) ⭐⭐⭐⭐

Andrews has four catches in every single game this season. With a floor like that, it’d be foolish to pass up this prop for such a good price in a game when Lamar Jackson is going to need his No. 1 target.

The Browns have the best pass defense in football, which is going to pose problems for the Ravens’ wide receivers. However, Jackson is still going to be throwing the ball plenty, especially in a game that will be closer than the first meeting between these two teams. Andrews has at least five targets in every game this season, including 10 in two contests. He may not get many yards on Sunday, but he will get plenty of catches.

Three of our five NFL prop betting sites are offering this prop. Each of them has a price of +124 or better, so you’re not in danger of missing out on value if you wait to see what the other sportsbooks offer before wagering.

Receiving prop picks made 11/10/2023 at 8:27 a.m. ET.

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