NFL Preseason Predictions & Odds Today: Expert Picks for Every Game Tonight

We've gathered the top picks today as the third week of the NFL preseason begins with Steelers vs. Panthers and Patriots vs. Giants.

Sean Tomlinson

Last Updated: August 21, 2025 12:51 PM EDT • 3 minute read

Pictured New York Giants quarterback Jaxson Dart signals as we look at our NFL preseason picks and odds today. Photo by Vincent Carchietta / Imagn.

The final week of NFL preseason football is upon us with anticipation building toward opening night of a new season, and we're diving into Week 3 as it begins on Thursday night with our NFL predictions and odds today.

The slate is light on Thursday with two games, though there's plenty of intrigue tied to the Steelers vs. Panthers and Patriots vs. Giants matchups tonight. We examine both further as part of our NFL preseason Week 3 predictions.

🏈 Best NFL predictions today

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Steelers-Panthers Under 36.5 (-115 via FanDuel) ⭐⭐⭐⭐
Giants -6.5 (-110 via Caesars) vs. Patriots ⭐⭐⭐⭐

📖 Check out our 2025 NFL preseason betting guide for our best betting strategies and full NFL preseason schedule.

💰 NFL preseason odds & expert picks for every game

Here are the latest odds and our expert picks for every game via the best NFL betting sites, which update live in real time. Follow the latest NFL scores for line history and matchup info.

📊 Steelers vs. Panthers odds

Date: Thursday, Aug. 21
Kickoff: 7 p.m. ET
Location: Bank of America Stadium (Charlotte, NC)
How to watch: NFL Network

🔮 Steelers vs. Panthers prediction

✅ Best pick: Under 36.5 (-115 via FanDuel)

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Here's a sneak peek at why our Gary Pearson is predicting the Panthers and Steelers will go Under 36.5:

"With help from the starters, Carolina has mustered just 13 points in two preseason games. I can't see the backups, led by the third- and fourth-string quarterbacks, spearheading an offensive explosion against a Pittsburgh defense that will, at least briefly, showcase most of its best players. "

👉 Check out his full analysis in our Steelers vs. Panthers prediction

📊 Patriots vs. Giants odds

Date: Thursday, Aug. 21
Kickoff: 8 p.m. ET
Location: MetLife Stadium (East Rutherford, NJ)
How to watch: Amazon Prime

🔮 Patriots vs. Giants prediction

✅ Best pick: Giants -6.5 (-110 via Caesars)

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Here's a sneak peek at why Isaiah Sirois is predicting the Giants will cover the spread of -6.5:

"The preseason often comes down to the better player under center, and New York’s quarterback depth chart is quite deep. Russell Wilson, Jaxson Dart, Jameis Winston, and Tommy DeVito can all move the ball effectively, and that’s helped the Giants win and cover in both preseason games thus far."

👉 Check out his full analysis in our Patriots vs. Giants prediction

🏆 NFL betting odds pages

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❓ NFL betting FAQs

What does the spread mean in betting NFL?

In NFL betting, the spread is the number of points a team is favored to win or lose by. It levels the playing field for bettors by giving an advantage or disadvantage in points. Bettors win if their pick covers the spread.

Where can I find top NFL betting odds?

Make sure you look at our top NFL betting sites to find the best odds for the NFL. These sportsbooks include Caesars, BetMGM, bet365, FanDuel, and DraftKings.

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Written by:
Sean Tomlinson

Sean Tomlinson has been in the sports media wilderness since 2009, and he joined Sportsbook Review in 2021. His work has been referenced in The New York Times and Forbes. He's also made appearances on The Fan 590 and TSN 1050. Sean is a regular bettor who places bets daily while using a handful of books. Most frequently, he uses FanDuel and bet365 due to the quality experience on those apps. While he'll often take an analytical approach, Sean enjoys the fun, recreational side of betting too, and embraces alternative markets on events like the Westminster Dog Show or Eurovision, or the many novelty props tied annually to the Super Bowl, for example. Beyond sports, Sean is also interested in the betting markets tied to politics, and especially those connected to American elections. He sees betting as a way to explore and engage in a deeper way, and takes that same view to his work. He plays poker periodically too, and is an avid fantasy sports player. Sean also previously spent time with Bleacher Report and theScore, all after earning his media studies degree from the University of Guelph-Humber.