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NFL Picks, Predictions Roundup Week 12: Best ML, ATS, O/U, and Prop Plays for Every Game

Sportsbook Review

Last Updated: November 27, 2022 7:12 AM EST • 1 min 12 sec read.

Jalen Hurts of the Philadelphia Eagles against the Indianapolis Colts at Lucas Oil Stadium on November 20, 2022 in Indianapolis, Indiana.
Jalen Hurts of the Philadelphia Eagles against the Indianapolis Colts at Lucas Oil Stadium on November 20, 2022 in Indianapolis, Indiana. Photo by Andy Lyons/Getty Images via AFP.

There's still plenty of football left in Week 12 following the three-game Thanksgiving Day slate as no teams are on bye this week. Check out below for all of our top NFL picks for Week 12.

Our NFL betting experts have been tracking the odds and lines for Week 12, and they offer their top ATS, O/U, and prop plays for the week below. Be sure to check out our NFL ATS power rankings, teaser picks, upset picks, trends to know, best bets, and touchdown props.

All season we'll also be keeping an eye on the odds to win the 2023 Super Bowl and each of the major NFL awards.

Click the links below to access our full NFL picks previews for every game in Week 12.

Check out our top sites for Maryland sports betting.

NFL Picks Week 12: Sunday

Chargers vs. Cardinals

Spread: Cardinals +3 (-105 via FanDuel)
Over/Under: Over 48 (-109 via BetRivers)
Prop: Austin Ekeler 1+ rushing touchdown, Keenan Allen 1+ receiving touchdown (+200 via DraftKings)

Raiders vs. Seahawks

Spread: Seahawks -3.5 (-110 via FanDuel)
Over/Under: Under 47.5 (-110 via DraftKings)
Prop: Davante Adams Over 85.5 receiving yards (-115 via BetMGM)

Rams vs. Chiefs

Spread: Chiefs -15 (-110 via PointsBet)
Over/Under: Under 42.5 (-108 via FanDuel)
Prop: Isiah Pacheco Over 62.5 rushing yards (-115 via DraftKings)

Saints vs. 49ers

Spread: 49ers -8.5 (-110 via FanDuel)
Over/Under: Under 43 (-110 via DraftKings)
Prop: Alvin Kamara Under 50.5 rushing yards (-115 via PointsBet)

Packers vs. Eagles

Spread: Eagles -6.5 (-110 via BetMGM)
Over/Under: Under 46.5 (-110 via Caesars)
Prop: Allen Lazard Under 46.5 receiving yards (-115 via DraftKings) 

NFL Picks Week 12: Monday

Steelers vs. Colts

Spread: Colts -2.5 (-107 via PointsBet)
Over/Under: Over 39 (-107 via PointsBet)
Prop: Diontae Johnson Over 45.5 receiving yards (-115 via DraftKings)

Top Week 12 NFL Picks

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Sportsbook Review
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