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NFL Predictions Week 16 2023: Picks & Odds for Marquee Games

Esten McLaren

Last Updated: December 24, 2023 4:17 PM EST • 1 min 54 sec read.

Lamar Jackson #8 of the Baltimore Ravens throws a touchdown pass as we look at our best NFL predictions for Week 16
Lamar Jackson #8 of the Baltimore Ravens throws a touchdown pass against the Jacksonville Jaguars during the second quarter at EverBank Stadium on December 17, 2023 in Jacksonville, Florida. Photo by Courtney Culbreath/Getty Images via AFP.

The NFL brings a jam-packed schedule for the holidays with games played Thursday, Saturday, Sunday, and Monday once again as we round up our betting experts' NFL predictions for Week 16 based on the best NFL odds.

There are 10 games on Christmas Eve, headlined by the Dallas Cowboys' visit to the Miami Dolphins in a near-must-win matchup for both sides, at least in terms of proving themselves as serious contenders by the Super Bowl odds.

The Week 16 slate will wrap up with a tripleheader on Christmas Day that will see the Las Vegas Raiders visit the Kansas City Chiefs and the New York Giants meet up with the floundering Philadelphia Eagles as precursors to what could be the NFL's game of the year and a potential Super Bowl preview between the Baltimore Ravens and San Francisco 49ers on Monday Night Football.

We're rounding up all of our NFL predictions for Week 16 to help you get the better of the NFL Week 16 odds from our best NFL betting sites.

NFL picks and predictions for Week 16

All times ET

NFL predictions Week 16: Sunday (Christmas Eve)

Cowboys vs. Dolphins pick: Over 51 (-110 via BetMGM, Caesars, bet365) ⭐⭐⭐

Cowboys-Dolphins prediction made by Mike Spector.

Patriots vs. Broncos pick: Bailey Zappe Over 179.5 passing yards (-114 via BetRivers) ⭐⭐⭐⭐

Patriots-Broncos prediction made by Andrew Brennan.

NFL predictions Week 16: Monday (Christmas Day)

Raiders vs. Chiefs pick: Patrick Mahomes Under 25.5 completions (-109 via BetRivers) ⭐⭐⭐

Raiders-Chiefs prediction made by Andrew Brennan.

Giants vs. Eagles pick: Tommy DeVito Over 184.5 passing yards (-110 via bet365) ⭐⭐⭐⭐

Giants-Eagles prediction made by Sean Tomlinson.

NFL predictions Week 16: Monday Night Football

Ravens vs. 49ers pick: 49ers team total Over 26.5 (-115 via Caesars) ⭐⭐⭐⭐

Ravens-49ers prediction made by Shane Jackson.

NFL expert picks Week 16

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Written By:
Esten McLaren
Esten is the Senior Publishing Editor for SportsbookReview.com. He previously spent time as the Managing Editor of SportsbookWire.com, and he has done freelance work in sports betting for TheLines, PlayPicks, and BettingPros. He's well versed in the NFL, NHL, MLB, and NBA, but his true passion is with the PGA Tour. Esten's always happy to chase a long shot and will never shy away from a futures bet, but he'll never stop backing Rory McIlroy in majors. He's also a recovering Ottawa Senators and Atlanta Falcons fan. Always bet against the Toronto Maple Leafs at plus money.