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Both Tampa Bay and San Francisco look for their second straight win, and quarterback Brock Purdy is the focus of one of our top Buccaneers vs. 49ers NFL player props for Week 11 based on the top NFL odds.

The San Francisco 49ers won the only meeting between these teams last season, and it was a 35-7 rout in Purdy’s first-ever NFL start. Purdy threw two touchdowns, and running back Christian McCaffrey added rushing and receiving scores.

This will be a stiff test for the Buccaneers. They’re averaging 19.8 points per game for the season (17th-best), while the San Fran defense has surrendered just 15.9 points per contest (second). Additionally, San Francisco has scored the second-most points per game in the league.

Check out our NFL Week 11 predictions and Week 11 best bets, along with our Week 11 NFL props to accompany our best Tampa Bay Buccaneers vs. San Francisco 49ers NFL player props for Week 11 (odds via our best NFL betting sites; pick confidence-based on a 1-to-5-star scale).

Buccaneers vs. 49ers NFL player props: Week 11

Brock Purdy Over 249.5 passing yards (-115 via Bet365) ⭐⭐⭐⭐

Brock Purdy passed 400 career attempts in San Francisco's Week 10 win over Jacksonville. He has a career 68.1 percent completion rate on 420 attempts, the highest of any quarterback with 400+ career passes thrown in NFL history. Only three teams have given up more passing yards than the Bucs this season, who are conceding an average of 266.8 yards per game through the air. Purdy’s passer rating of 109.9 is number one in the league, and his average of 258.8 passing yards per game is well Over the total. 

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Rachaad White Under 44.5 rushing yards (-110 via bet365) ⭐⭐⭐⭐

The Buccaneers are averaging 3.06 yards per carry this season, on pace to be their second consecutive campaign with the NFL's lowest rushing average. The last time a team had the lowest yards per carry two years in a row was the Arizona Cardinals in 2005 and 2006. White is averaging 47.6 yards per game, which is Over the rushing prop total, but was held to under 40 yards by the Eagles and less than 30 rushing yards by the Lions, who rank one and two, respectively, in rushing yards defended. Third in that ranking is the San Francisco 49ers. 

Mike Evans Over 55.5 receiving yards (-110 via bet365) ⭐⭐⭐

Mike Evans already has 737 receiving yards this season and is on track for a career year. He leads the Bucs in targets (70), yards per reception (17.1), touchdowns (6) and receiving yards per game (81.9). In last week’s win over the Titans, Evans was targeted 10 times, catching six passes for 143 yards and a touchdown. Whilst Tampa Bay’s underperforming rushing offense will face a stern test against one of the league’s best-run defenses, San Francisco ranks 15th against the pass (238.3 YPG).

Buccaneers vs. 49ers player props made Friday at 12 p.m. ET

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