Skip to main content
Trevor Lawrence of the Jacksonville Jaguars calls a play as part of our Week 10 NFL predictions for 49ers vs. Jaguars
Trevor Lawrence #16 of the Jacksonville Jaguars calls a play during the first quarter of the game against the Pittsburgh Steelers at Acrisure Stadium on October 29, 2023 in Pittsburgh, Pennsylvania. Joe Sargent/Getty Images/AFP

Our Trevor Lawrence NFL player prop predictions question whether the Jacksonville Jaguars quarterback is facing a motivated San Francisco 49ers defense in Week 10. We always look for the best NFL odds from our best sports betting apps when making our NFL picks.

The Jacksonville Jaguars are rolling. They boast one of the best records in the AFC and are sporting an NFL-high, five-game winning streak. Fittingly, the Jags have quietly been climbing the Super Bowl odds lists, too.

Meanwhile, despite the recent challenges the San Francisco 49ers have been facing, particularly in their offensive performance, the addition of a noteworthy player to their defensive line in Chase Young prior to the trade deadline indicates a strategic effort to enhance their capabilities. This acquisition presents a potential game-changer for the Niners, offering a significant boost that could alter the dynamics of their team. While the struggles may hint at potential difficulties, the focus on fortifying the defensive side suggests a proactive approach to regaining momentum.

Head over to our NFL Week 10 predictions and 49ers-Jaguars prop predictions, along with our Week 10 NFL props to accompany our best Trevor Lawrence NFL player prop predictions (odds via our best NFL betting sites; Pick confidence is based on a 1-to-5-star scale).

Trevor Lawrence NFL player prop predictions for Week 10

Not intended for use in MA
Affiliate Disclosure:
Sportsbook Review may receive advertising commissions for visits to a sportsbook

Trevor Lawrence player props

Trevor Lawrence Over 23.5 completions (+100 via DraftKings) ⭐⭐⭐⭐

Trevor Lawrence has led the Jaguars to five straight wins entering Week 10, but it’s not entirely accurate to say that he’s carried the team all by himself during this stretch. During the streak, the Jacksonville defense has held opponents to 16.2 points per game.

But this week against San Francisco, we could see Lawrence asked to shoulder more of the offensive responsibilities. The Niners have a team total of 24.5 points, meaning it could take more from Lawrence to compete in this one. That’s especially true if San Francisco’s fifth-ranked rushing defense (86.1 opponent rushing yards per game) limits Jags running back Travis Etienne.

Because of their run-stuffing nature, the Niners tend to allow opposing quarterbacks to complete more passes than most teams--because teams are throwing more against them. Lawrence has cleared this 23.5-completion line four times, but I like his chances against a team allowing 26.5 completions per game (30th in the NFL). At +100 odds, DraftKings has the best odds on this prop.

No Sweat Bet Up To $1,500

+ No Sweat SGP Every Day of NBA Playoffs 🏀

Sportsbook Review may receive advertising commissions for visits to a sportsbook or casino betting site. 21+. Gambling can be addictive, please play responsibly

Visit our Google News page and click "Follow" (⭐) for the latest odds, picks and news!  

Trevor Lawrence Over 15.5 rushing yards (-110 via bet365) ⭐⭐⭐ 

Quarterbacks with solid mobility like Cincinnati Bengals quarterback Joe Burrow and then Arizona Cardinals signal-caller Joshua Dobbs have found success exploiting that element of the run defense against San Francisco to the extent that it’s worth scoping out the lines on Lawrence’s rushing yards.

Seeing the prop line at 15.5 yards makes it a solid play. Lawrence has cleared this mark five times, landing right below it at 15 yards on the dot in one other game. His efficiency when he takes off to run has been strong, as Lawrence has averaged 5.1 yards per carry this season. He’s had at least one carry of 8+ yards in every game played; as long as he scampers at least a few times, precedent suggests he gets there.

Avoid FanDuel for a bet on this prop (16.5 yards, -114). Our other best sports betting apps offer the line at 15.5, but spots like Caesars (-117) and DraftKings (-125) don’t offer compelling odds on Over. Head to bet365 for -110 odds on the 15.5-yard line.

Bet $5, Get $150 in Bonus Bets

Gambling problem? Call 1-800-GAMBLER

Sportsbook Review may receive advertising commissions for visits to a sportsbook or casino betting site. 21+. Gambling can be addictive, please play responsibly

Lawrence Under 1.5 passing touchdowns (-135 via bet365) ⭐⭐⭐

Jacksonville’s team total sits at 20.5 for this game, so a couple of touchdowns should be in the cards. And the 49ers aren’t impenetrable against the pass, allowing 1.3 passing TDs per game on the year.

At the end of the day, we like Lawrence to post solid passing numbers. But it’s difficult to project multiple passing touchdowns for the Jaguars in this matchup against a San Francisco defense debuting newly acquired Chase Young on the pass rush. Though San Francisco is stingy against the run, Jacksonville wants to run it in the red zone; Etienne has three multi-touchdown games in the past four weeks, which could boost our cause here if he eats up some of Lawrence’s scoring chances.

Stay away from FanDuel’s inflated -160 odds on this Under bet. DraftKings and BetMGM offer acceptable value at -140, and the same story for Caesars at -137. But bet365 comes in again with the best odds on this one at -135.

Trevor Lawrence player prop picks made 11/11/2023 at 10:50 a.m. ET.

NFL betting odds pages

Check out our best NFL betting sites:

(21+. Gambling Problem? Call 1-800-GAMBLER)
* Bonuses not applicable in Ontario.

Related pages