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Carson Beck of the Georgia Bulldogs warms up prior to the game against the UAB Blazers at Sanford Stadium as we look at our college football parlay picks.
Carson Beck of the Georgia Bulldogs warms up prior to the game against the UAB Blazers at Sanford Stadium. Photo Todd Kirkland/Getty Images/AFP.

Despite narrowly missing out on cashing a three-leg parlay that would have paid out at +407 in Week 4, we're back to discuss another strong three-leg college football parlay for Week 5, based on the best NCAAF odds from our best sports betting apps.

The first two legs of this week's parlay involve contrarian plays. We're betting against two of the most exciting offenses in college football, leading up to a high-profile matchup. Additionally, we're going against the No. 1 team in the country as they embark on their first road game of the season.

Then we round out our parlay with a moneyline play involving two Group of Five schools, and a point spread that's been moving decisively in one team’s favor thus far.

Here are our best college football parlay predictions for Week 5 (odds via our best college football betting sites; Pick confidence is based on a 1-to-5-star scale).

College football parlay predictions: Week 5

(Odds via DraftKings)

  • USC-Colorado Under 73.5 (-110) ⭐⭐⭐⭐
  • Auburn +7.5 first half spread (-112) vs. Georgia ⭐⭐⭐⭐
  • Memphis ML (-175) vs. Boise State ⭐⭐⭐⭐

Combined odds: +467 via DraftKings

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College football parlay Week 5

USC-Colorado Under 73.5 (-110) ⭐⭐⭐⭐

All of our best sportsbooks will likely be rooting heavily for the Under to cash in this matchup. Fading the public and siding with the books’ rooting interest is typically where we prefer to be with our wagers.

USC isn't known for its juggernaut defense, but it can follow Oregon's blueprint to get pressure on Shedeur Sanders. The Ducks pressured Sanders on 20 dropbacks and sacked him seven times, and he seemed to be running for his life the entire game during Week 4. That impressive defensive performance cannot be understated, as Sanders entered the game ranking fourth in completion rate (among 129 FBS quarterbacks with a minimum of 50 dropbacks), and he had registered the third-lowest off-target rate.

The Trojans will also benefit from getting more film on Sanders, and his 42nd-ranked success rate on third-down attempts was always due to regress when entering conference play.

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We also need Colorado’s defense to show up against a USC offense that scored the fourth-most points (56) in a season opener during the AP poll era, and the team's 122 points through the first two games was the most since 2015. However, we're banking on the Trojans taking their foot off the gas like Oregon did if they race out to a significant halftime lead. Plus, this line doesn't account for how difficult it will be for a West Coast team to get up for a noon ET kickoff. 

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Auburn +7.5 first-half spread vs. Georgia (-112) ⭐⭐⭐⭐

Georgia has covered during six consecutive games against Auburn, and the team may make it seven in Week 5. However, we're jumping at the opportunity to buy low on the Tigers after a disappointing 27-10 loss to Texas A&M. We expect them to stay within a touchdown through the first 60 minutes.

Jordan-Hare Stadium is one of the most challenging environments in the country, so Georgia backers are putting a lot of trust in quarterback Carson Beck during his first road start. He logged just 168 career snaps before 2023 and threw for 310 yards as a backup in 2022.

The point spread for this matchup has been plummeting, even after Auburn's disappointing loss to the Aggies. The Tigers have gone from as high as +18.5-point underdogs on Sunday morning down to +14.5 currently. The line has been shifting drastically despite 70% of the early wagers landing on Georgia, so the books must be wary of respected money landing on the underdogs.

The Bulldogs started slow against South Carolina before trailing at the half for the first time in a game since 2020. We'll therefore take anything with Auburn getting more than a touchdown, as the 2023 Georgia team is being unfairly compared to its last two national championship squads.

Memphis ML vs. Boise State (-175) ⭐⭐⭐⭐

The third leg of our parlay involves another game that's been experiencing significant line movement, as Memphis ballooned from 1.5-point favorites on Sunday night to 3.5-point favorites at all of our best live betting sites now.

Memphis quarterback Seth Henigan has completed nearly 70% of his pass attempts during 2023. While he's thrown at least one interception in three of four games, Henigan should be comfortable in the pocket against a Boise State defense that ranks 116th or lower in sack percentage and pass-rush grade. And the Tigers’ versatility on the ground (they boast three players with multiple rushing touchdowns in 2023) should lead to fits for a Broncos defense that's allowed the second-most yards per play (8.0) of any FBS team in 2023. 

Even if Henigan’s turnover problems continue, Memphis should still hold a significant edge in the passing game, as its defense ranks tops among all FBS teams in passing explosiveness and passing success rate allowed. That will allow the Tigers to play their cornerbacks on an island if necessary and key in on Boise State’s running game, which totaled 241 rushing yards in Week 4 versus San Diego State, with 205 coming from Ashton Jeanty.

This is a four-star play, as Memphis has done well to protect its home field in recent years, going 10-3 straight up as a home favorite since 2021.  

College football parlay picks made 9/26/2023 at 4:27 p.m. ET.

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