March Madness Sweet 16 Predictions Today: Expert Picks & Scores for Every NCAA Tournament Game

The last four tickets to the Elite Eight will be punched tonight in the Sweet 16, as we offer our March Madness predictions today for all four NCAA Tournament games:

• No. 2 Michigan State vs. No. 6 Ole Miss, 7:09 p.m. ET (CBS)
• No. 2 Tennessee vs. No. 3 Kentucky, 7:39 p.m. ET (TBS/truTV)
• No. 1 Auburn vs. No. 5 Michigan, 9:39 p.m. ET (CBS)
• No. 1 Houston vs. No. 4 Purdue, 10:09 p.m. ET (TBS/truTV)

👉 Want to bet on the Sweet 16? Check out the latest March Madness Sweet 16 odds & full schedule and the rest of our March Madness predictions.

💰 March Madness Sweet 16 predictions & NCAA Tournament odds today

🏀 No. 1 Auburn vs. No. 5 Michigan, 9:39 p.m. ET (CBS), South Region

✅ ATS prediction: Michigan to cover the spread +8.5 ⭐⭐⭐
🎯 Score prediction: Auburn 79, Michigan 73

Here's why Phil Wood is picking Michigan to cover the spread (+8.5):

"The Wolverines have rattled off five consecutive wins. Michigan showed it could win any type of game during the first two rounds of the NCAA Tournament. The Wolverines took a low-scoring affair against the UC San Diego Tritons before outscoring the Texas A&M Aggies on their way to a 91-79 win."

👉 For more analysis & latest odds, check out our Auburn vs. Michigan prediction and Auburn vs. Michigan player props.

📊 Auburn vs. Michigan odds

🏀 No. 1 Houston vs. No. 4 Purdue, 10:09 p.m. ET (TBS/truTV), Midwest Region

✅ ATS prediction: Houston to cover the spread -7.5 ⭐⭐⭐⭐
🎯 Score prediction: Houston 75, Purdue 64

Here's why Brenden Schaeffer is picking Houston to cover the spread (-7.5):

"Purdue benefitted from High Point and McNeese being non-existent on the glass. The Boilermakers out-rebounded both mid-major opponents by a significant margin despite ranking outside the top 110 in both offensive and defensive rebounding efficiency, per Torvik. Houston should be more physical on both ends, and the team with the top-ranked adjusted defensive efficiency in the nation won’t allow so many easy buckets in the paint as Purdue’s previous opponents."

👉 For more analysis & latest odds, check out our Houston vs. Purdue prediction and Houston vs. Purdue player props.

📊 Houston vs. Purdue odds

🏀 Best March Madness odds, predictions & expert picks today

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🗓️ Sweet 16 schedule & TV info today

• No. 2 Michigan State vs. No. 6 Ole Miss, 7:09 p.m. ET (CBS), South Region
• No. 2 Tennessee vs. No. 3 Kentucky, 7:39 p.m. ET (TBS/truTV), Midwest Region
• No. 1 Auburn vs. No. 5 Michigan, 9:39 p.m. ET (CBS), South Region
• No. 1 Houston vs. No. 4 Purdue, 10:09 p.m. ET (TBS/truTV), Midwest Region

💰 March Madness betting odds pages

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