March Madness AI Predictions Today: Sweet 16 Picks & Exact Score for Friday's NCAA Tournament Games

Last updated: March 28, 2025 2:04 PM EDT • 5 min read X Social Google News Link

Each day, we're compiling all of our March Madness AI predictions with picks and exact score projections courtesy of ChatGPT for every game in the NCAA Tournament.
Our March Madness AI bracket predictions rank in the top 0.5% of all brackets entering tonight's Sweet 16 games, but will our AI-generated insights via ChatGPT have the same success today?
👉 Want to bet on the Sweet 16? Check out the latest March Madness Sweet 16 odds & full schedule and the rest of our March Madness predictions.
🤖 March Madness AI predictions & Sweet 16 exact score projections today

🏀 Michigan State vs. Ole Miss prediction, 7:09 p.m. ET (CBS), South Region
🖥️ AI score prediction: Michigan State 75, Ole Miss 64
- Michigan State typically performs well in high-pressure games and has a reputation for strong defense and efficient offense.
- Michigan State usually has a superior defense, and the Spartans’ ability to shut down key scorers from Ole Miss will likely be a decisive factor.
- Tom Izzo is one of the best March Madness coaches in history. His ability to adapt, make in-game adjustments, and prepare his team for tight tournament games often gives Michigan State the edge.
🧠 For more expert (human) analysis, check out our Michigan State vs. Ole Miss prediction.
📊 Michigan State vs. Ole Miss odds
🏀 Tennessee vs. Kentucky prediction, 7:39 p.m. ET (TBS/truTV), Midwest Region
🖥️ AI score prediction: Tennessee 72, Kentucky 68
- Tennessee's perimeter defense will be crucial: The Vols rank among the nation’s top 15 in defensive efficiency, particularly in guarding the 3-point line. With Kentucky missing key perimeter players (Robinson and Kriisa), expect Tennessee to limit outside scoring.
- Zakai Zeigler’s playmaking X-factor: Zeigler’s recent 12-assist, 0-turnover performance highlights his elite ball distribution. His ability to create open looks and control the tempo gives Tennessee an edge.
- Kentucky's frontcourt could pose problems: Despite their guard injuries, Kentucky’s rebounding advantage (top 10 in offensive boards per game) should keep them competitive. They’ll rely heavily on inside scoring to offset their limited backcourt depth.
🧠 For more expert (human) analysis, check out our Tennessee vs. Kentucky prediction.
📊 Tennessee vs. Kentucky odds
🏀 Auburn vs. Michigan prediction, 9:39 p.m. ET (CBS), South Region
🖥️ AI score prediction: Auburn 74, Michigan 68
- The Tigers’ strengths include high-pressure defense, the ability to score in bunches, and excellent perimeter shooting.
- The Wolverines’ strengths include physical defense, disciplined half-court offense, and strong rebounding.
- Bruce Pearl is known for getting his players to play with high energy and passion, especially in the tournament. His ability to make in-game adjustments will be critical in a likely close contest.
🧠 For more expert (human) analysis, check out our Auburn vs. Michigan prediction.
📊 Auburn vs. Michigan odds
🏀 Houston vs. Purdue prediction, 10:09 p.m. ET (TBS/truTV), Midwest Region
🖥️ AI score prediction: Houston 70, Purdue 62
- Houston's dominant defense: The Cougars allow just 58.4 points per game, ranking among the nation's best in defensive efficiency.
- Purdue's offensive challenges: The Boilermakers average 77.7 points per game but have struggled against top-tier defenses.
- Houston's depth bolstered by resilient players: Despite battling significant pain from a surgically repaired Achilles tendon, guard Terrance Arceneaux has played in 36 games this season, showcasing the Cougars' depth and resilience.
🧠 For more expert (human) analysis, check out our Houston vs. Purdue prediction.
📊 Houston vs. Purdue odds
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🗓️ Sweet 16 schedule & TV info today
- No. 2 Michigan State vs. No. 6 Ole Miss, 7:09 p.m. ET (CBS), South Region
- No. 2 Tennessee vs. No. 3 Kentucky, 7:39 p.m. ET (TBS/truTV), Midwest Region
- No. 1 Auburn vs. No. 5 Michigan, 9:39 p.m. ET (CBS), South Region
- No. 1 Houston vs. No. 4 Purdue, 10:09 p.m. ET (TBS/truTV), Midwest Region
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