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Duke vs. Wake Forest Prediction, Odds & Preview Today: Best Picks for Jan. 25

Rob Paul

Last Updated: January 25, 2025 12:22 PM EST • 2 min 59 sec read.

Duke's Cooper Flagg looks to pass the ball against Boston College. We're backing Flagg in our Duke vs. Wake Forest prediction.
Pictured: Duke's Cooper Flagg looks to pass the ball against Boston College. Photo by Eric Canha via Imagn Images.

Wake Forest (15-4) will look to end Duke's (16-2) 12-game winning streak when the ACC foes play today at 4:30 p.m. ET (ESPN) at LJVM Coliseum in Winston-Salem, N.C.

Our Duke vs. Wake Forest prediction, odds & preview expect the Blue Devils to live up to their billing as the March Madness odds favorites.

Behind the play of Wooden Award odds leader Cooper Flagg, Duke is poised to cover as a 10.5-point favorite on the road.

Keep the action rolling after this tilt with my Houston vs. Kansas prediction.

Duke vs. Wake Forest predictions today

College basketball picks based on the odds from our best March Madness betting sites.

  • Against the spread pick: Duke -10.5 (-110 via FanDuel) vs. Wake Forest ⭐⭐⭐⭐
  • My best pick: Cooper Flagg Over 12.5 rebounds and assists (-130 via FanDuel) ⭐⭐⭐⭐

Duke vs. Wake Forest ATS prediction

Duke to cover the spread: -10.5 ⭐⭐⭐⭐

Despite Wake Forest's impressive start to conference play, the Demon Deacons have failed to beat a relevant team in the ACC. In fact Steve Forbes' team hasn't really had a quality win since beating Michigan in November.

Wake is just 8-10-1 ATS this season and 1-4 ATS when facing teams ranked in the top 45 by KenPom. Even with their impressive record on paper, which makes them seem NCAA Tournament-worthy, the Deacs are borderline frauds with the 95th-ranked strength of schedule this season and an offense that's just 166th in adjusted efficiency.

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Bracket Matrix doesn't even have Wake reaching the tournament, so I don't see any way they'll be able to keep up with a Blue Devils team that's ranked No. 1 by KenPom thanks to the fantastic freshman duo of Flagg and Kon Knueppel.

Those two have Duke 12-6 ATS this season and 8-4 when favored by double-digit points - that includes covering back-to-back 23-plus-point spreads in ACC play last week. If the Blue Devils cover against Wake, a $10 bet pays a $9.09 profit.

Best odds: -110 via FanDuel | Implied probability: 52.38%

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Best Duke vs. Wake Forest pick

Our NEW college basketball player prop odds tool can help you find the best odds on any market across legal sportsbooks in your area!

Cooper Flagg Over 12.5 rebounds and assists ⭐⭐⭐⭐

There's a reason Duke is already minus money by the Final Four odds. Flagg is living up to the hype of being a generational talent, and he seems to get better every time he steps on the court.

While his scoring is the biggest reason he's the favorite by the 2025 NBA Draft odds, it's his well-rounded skill set that has him looking like the face of college basketball right now. Flagg is the only player in the country averaging 19-plus points, eight-plus rebounds, and four-plus assists per game.

He's combined to go Over 12.5 rebounds and assists in four of his last five games and should again against a Wake team that's 289th in the country in rebounds per game (33.9) and 221st in rebounds allowed (35.1). If Flagg hits the Over, a $10 bet pays a $7.69 profit.

Best odds: -130 via FanDuel | Implied probability: 56.52%

Live Duke vs. Wake Forest odds

See all of this week's college basketball odds and NCAAB scores.

Duke vs. Wake Forest opening odds

  • Spread: Duke -10.5 (-110) | Wake Forest +10.5 (-110)
  • Over/Under: Over 135 (-110) | Under 135 (-110)
  • Moneyline: Duke -500 | Wake Forest +491

Duke vs. Wake Forest game info

  • When: Saturday, Jan. 25
  • Tipoff: 4:30 p.m. ET
  • Where: LJVM Coliseum (Winston-Salem, N.C.)
  • How to watch: ESPN
  • Favorite: Duke -10.5 (-110 via FanDuel)

College basketball betting odds pages

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Written By:
Rob Paul
Rob is a Publishing Editor at Sportsbook Review. He’s been with the team since early 2024, with this being his first full-time role in the sports betting industry. Before joining SportsbookReview.com, he contributed to various sports outlets, including FanSided and Pro Football Network. During that period, he spent five years working full-time as a local community journalist, after attending Durham College for journalism and Wilfrid Laurier University for history. He previously hosted an NFL draft and college football-focused podcast where he had the opportunity to interact with future NFL players such as Maxx Crosby and Quinn Meinerz. Rob has spent multiple years working as a freelance podcast producer for numerous sports-related podcasts while making guest appearances on several college football shows. He’s also made guest appearances on SportsTalk Mississippi on several occasions to talk all things NFL draft. Rob values the way sports betting acts as a catalyst for telling stories and growing interest in certain sports, particularly FCS football, WNBA, and mid-major college basketball. He’s always been drawn to the more obscure teams and conferences in major college sports, but most of all, Rob loves using stats to find the best player props to back.