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Kansas State Wildcats head coach Chris Klieman looks on as we offer our best Big 12 predictions, odds, and picks for college football Week 5.
Kansas State Wildcats head coach Chris Klieman looks on against the Brigham Young Cougars. Photo by Rob Gray / Imagn Images.

The Big 12 delivered as the new chaos league last week when Colorado won in an overtime thriller against TCU and BYU upset Kansas State with a convincing 38-9 victory.

Our Big 12 predictions expect Saturday’s Week 5 slate to be just as entertaining as part of our Week 5 college football predictions.

The action will start with what was expected to be a conference title game preview between Kansas State and Oklahoma State and end with a late-night showdown between former Pac-12 foes Utah and Arizona.

Big 12 best bets: Week 5

College football odds as of Thursday and subject to change. Track the college football scores for the latest line movement and matchup info.

Best Big 12 predictions this week

College football picks made Thursday; odds subject to change. Our NEW college football player prop odds tool can help you find the best odds on any market across legal sportsbooks in your area!

Kansas State -5 (-108) ⭐⭐⭐⭐

As mentioned in my Oklahoma State vs. Kansas State prediction, I’m buying a bounce-back showing from the Wildcats at home. This has usually been the best spot to back K-State under head coach Chris Klieman.

The Wildcats haven’t dropped consecutive games since November 2021. In their last nine games following a loss, they have an average margin of victory of 24.8 points in the following contest.

Kansas State has won by at least a touchdown in all nine of those games after a loss. The best sportsbooks have provided us with a gift with this spread.

Best odds: -108 via DraftKings | Implied probability: 51.92%

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Kansas moneyline (-122) ⭐⭐⭐⭐

I bet on the Jayhawks last week, citing that they have been unlucky and have inexplicably blown games. They then surrendered a double-digit lead in the fourth quarter of their 32-28 road loss to West Virginia.

Kansas has lost three in a row, falling to 1-3 on the year. But this team continues to put itself in a position to win games. According to SP+, Kansas had a postgame win expectancy of 86.6% in its home loss to UNLV and 57.7% in its loss to Illinois.

The market believes this is the week for KU’s first FBS victory against TCU, pushing the spread from -1.5 to -2.5 across our best sports betting apps. I like betting Kansas’ moneyline value at -125 or better instead.

Best odds: -122 via FanDuel | Implied probability: 54.95%

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Texas Tech -2.5 (-110) ⭐⭐⭐

It’s funny how life works. I was not a fan of Texas Tech last year when the market rated this team as a Big 12 contender, but I’ve found myself betting on the Red Raiders more this season following their 7-6 campaign.

The market has pushed this spread from 3.5 to 2.5 in favor of Cincinnati, creating a buy point for me now that it’s below a key number. The Red Raiders have only lost two home games since November 2022, with those defeats coming at the hands of Oregon and Kansas State.

Cincinnati is off to a 3-1 start to the season, but the defense has benefitted from leading the country in starting field position. The Bearcats’ three wins have been against Towson, Miami (OH), and a one-win Houston team.

Consider me skeptical that Cincinnati is ready for the challenge in Lubbock this weekend.

Best odds: -110 via BetMGM | Implied probability: 52.38%

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College football picks roundup: Week 5

College football betting odds pages

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