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D.J. Moore of the Carolina Panthers runs with the ball during the first half of the game against the New York Giants.
D.J. Moore of the Carolina Panthers runs with the ball during the first half of the game against the New York Giants. Al Bello/Getty Images/AFP.

The Denver Broncos own the worst-scoring offense in football, but face a 3-8 Carolina Panthers team on its third quarterback. Read on for our top Broncos-Panthers NFL picks.

The Russell Wilson experiment has been a failure in Denver. The team's offense is averaging just 14.7 points per game, and the unit has scored more than 20 points just twice over 10 contests.

Meanwhile, the Panthers' QB carousel has finally led to Sam Darnold getting a start. Darnold will be the starter for the first time in 2022 while replacing a healthy yet ineffective Baker Mayfield.

Here are our Broncos-Panthers picks and predictions for Week 12 (odds via DraftKings Sportsbook, FanDuel Sportsbook, and PointsBet; Pick confidence is based on a 1-to-5-star scale).

Check out our roundup, ATS pick rankings, and odds and lines for Week 12.

Broncos vs. Panthers Game Info

Date: Sunday, November 27, 1:00 p.m. ET
TV: FOX
Location: Bank of America Stadium, Charlotte, NC
Weather: 65 degrees, 25% chance of precipitation, 10-mph winds

Broncos vs. Panthers Odds

Broncos vs. Panthers Odds Analysis

Denver was installed as a 2.5-point favorite, but the betting public has supported Carolina, causing the line to drop to 1. 

Currently, 54% of the cash is on the Panthers, while 51% of the tickets are on the Broncos. 

The total was set at a modest 37 points, but still has dropped to 36.5. The Under is still drawing 77% of the cash and 53% of the tickets.

Check out our top sites for Maryland sports betting.

Broncos vs. Panthers Picks

Broncos vs. Panthers ATS Pick

Panthers +2.5 (-114) ★★★

The Broncos are 3-7 against the spread in 2022 while covering just once on the road. There's no reason for them to be the road favorite, even if their team looks better than Carolina’s squad on paper. 

The Panthers have easily covered the spread in their last two home games. They won 25-15 as 2.5-point underdogs against the Atlanta Falcons, and 21-3 as 13-point underdogs against the Tampa Bay Buccanneers.

Sam Darnold brings an unknown element to this game, but it'll be a low-scoring contest. Additionally, only one Denver game has been decided by more than a single score. This is going to be tight from start to finish, and the advantage goes to the home team.

Broncos vs. Panthers O/U Pick

Under 36.5 (-107) ★★★★

It’s hard not to feel bad for the Broncos’ defense, as the team continues to let the unit down. The group has allowed the third-fewest points per game in the league, holding every team except the Raiders to fewer than 20 points.

That stout defense will keep enjoying great success against the Panthers. Carolina is averaging just 18.8 points per game, and how Darnold will play is a complete mystery.

Even if Darnold fares well, his team still likely won’t score in the 20s against this defense. And since the Broncos’ offense is a complete disaster and has done nothing recently to make it seem like that will change, expect a final in the low to mid-teens.

Check out our top trends to know for Week 12.

Broncos vs. Panthers Prop Pick

Wilson Over 219.5 Passing Yards (-115) ★★★

Russell Wilson has been a disappointment in 2022. However, while passing touchdowns and winning have been problems, he's still piling up passing yardage. He's thrown for over 220 yards in six of his nine games this season. 

Wilson has recorded at least 247 yards in every game over the past three weeks. The Panthers’ defense is coming off a strong performance against Lamar Jackson in Week 11, but the unit is allowing 220.5 passing yards per game overall.

Check out our Over/Under picks for Week 12.

Where to Bet on Broncos-Panthers Picks

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 Broncos-Panthers picks made 11/23/2022 at 7:58 p.m. ET.